Results 61 to 70 of about 56,309 (261)

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions [PDF]

, 2018
Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with polyethylene glycol (PEG) 1450 and hypromellose acetate succinate (HPMCAS-HF) to increase NIF solubility while achieving acceptable physical ...
Chougule, Mahavir B., Dave, Vivek S, Gavireddi, Monika, Gupta, Deepak, Haware, Rahul V., Stagner, William C, Vinjamuri, Bhavani Prasad   +6 more
core   +1 more source

A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]

, 2012
Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro, Barzegar-Jalali, Azim, Barzegar-Jalali, Mohammad, Mohammadi, Ghobad, Mohammadi, Kaivan, Nokhodchi, Ali, Valizadeh, Hadi   +6 more
core   +3 more sources

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

The Antihypertensive Drug Nifedipine Modulates the Metabolism of Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells

Frontiers in Endocrinology, 2019
Aging is associated with the development of various chronic diseases, in which both cardiovascular disorders and osteoarthritis are dominant. Currently, there is no effective treatment for osteoarthritis, whereas hypertension is often treated with L-type
Ilona Uzieliene, Eiva Bernotiene, Greta Rakauskiene, Jaroslav Denkovskij, Edvardas Bagdonas, Zygmunt Mackiewicz, Narunas Porvaneckas, Giedrius Kvederas, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri   +11 more
doaj   +1 more source

The prion protein constitutively controls neuronal store-operated ca2+ entry through Fyn Kinase [PDF]

, 2015
The prion protein (PrPC) is a cell surface glycoprotein mainly expressed in neurons, whose misfolded isoforms generate the prion responsible for incurable neurodegenerative disorders.
Agnese eDe Mario, Alessandro eBertoli, Andrew Francis Hill, Angela eCastellani, Caterina ePeggion, Dmitry eLim, Maria Catia eSorgato, Maria Catia eSorgato, Maria Lina eMassimino   +8 more
core   +4 more sources

Cost‐effectiveness of a randomized controlled trial comparing low‐dose aspirin to placebo for the prevention of recurrent preterm birth

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 399-407, April 2025.
Abstract To assess the cost‐effectiveness of low‐dose aspirin compared to placebo for the prevention of recurrent preterm birth from a healthcare perspective. This was a cost‐effectiveness analysis alongside a multicenter, randomized, double‐blinded, placebo‐controlled trial.
Anadeijda J. E. M. C. Landman, Hana M. Broulikova, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Karin C. Vollebregt, Elisabeth M. A. Boormans, Henk A. Bremer, Esther Tuinman, Josje Langenveld, Flip van der Made, Robbert J. P. Rijnders, Huib A. A. M. van Vliet, Liv M. Freeman, Roel de Heus, Judith Blaauw, Ineke Krabbendam, Rafli van de Laar, Marieke F. G. Verberg, Hubertina C. J. Scheepers, Ben W. Mol, Christianne J. M. de Groot, Martijn A. Oudijk, Judith E. Bosmans, Marjon A. de Boer   +24 more
wiley   +1 more source

Nifedipine promotes the proliferation and migration of breast cancer cells.

PLoS ONE, 2014
Nifedipine is widely used as a calcium channel blocker (CCB) to treat angina and hypertension,but it is controversial with respect the risk of stimulation of cancers. In this study, we demonstrated that nifedipine promoted the proliferation and migration
Dong-Qing Guo, Hao Zhang, Sheng-Jiang Tan, Yu-Chun Gu   +3 more
doaj   +1 more source

ESTIMATION OF ANTIHYPERTENSIVE EFFECT EQUABILITY FOR TWO PRESENTATIONS OF NIFEDIPINE WITH DAILY BLOOD PRESSURE MONITORING

Рациональная фармакотерапия в кардиологии, 2015
Aim. To compare information value of antihypertensive effect equability parameters for two drug formulations of nifedipine: long-acting one (nifedipine-XL) and short-acting one (nifedipine-sa).Material and methods. 147 patients with arterial hypertension
V. M. Gorbunov, E. V. Alimova, A. D. Deev   +2 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source