Results 11 to 20 of about 59,868 (281)
Biomedicines, 2023 Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no effective treatments are currently available. Arterial hypertension is a common comorbidity in OA patients, and antihypertensive drugs, such as nifedipine (NIF),
Viktorija Aleksiuk +8 more
doaj +1 more source
L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc
JOR SPINE, Volume 5, Issue 4, December 2022., 2022 This study investigated the expression and function of voltage‐gated ion channels in the intervertebral disc. One channel, Cav2.2, was found to be upregulated in degeneration, while L‐type voltage gated calcium channels were found to be involved in mediating calcium signaling and the response of disc cells to dynamic compression.
Philip Poillot +3 more
wiley +1 more source
A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine
Molecules, 2020 Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection-spray drying method.
Ye Bi +6 more
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Models of the cardiac L‐type calcium current: A quantitative review
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 We discuss 73 published models of mammalian ICaL and find differences in gating kinetics, electrochemical driving force, and sensitivity to internal calcium concentrations, leading to considerable variability in their predictions. Abstract The L‐type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital
Aditi Agrawal +7 more
wiley +1 more source
National Journal of Medical Research, 2023 Introduction: Preterm labour follows a spontaneous commencement of labour in two-thirds of preterm birth instances. Obstetricians must consider both treatment options for the management of preterm.
Ashish P Kalburgi, Nitin Kshirsagar
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Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 16-42, January 2023., 2023 Abstract Background Drug‐associated delirium is a common but potentially preventable neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for delirium‐associated medication is uncertain due to a lack of high‐quality studies.
Michael Reisinger +4 more
wiley +1 more source
Clinical Cardiology, 1988 AbstractOverdose with 300 mg of nifedipine in a 54‐year‐old woman led to profound hypotension and reflex tachycardia. The patient was treated with intravenous fluids, calcium gluconate, and dopamine. Cardiac rhythm disturbances, hypoglycemia, and myocardial depression were not found. Recovery was rapid and uneventful. The clinical aspects of nifedipine
D, Whitebloom, J, Fitzharris
openaire +2 more sources
The Journal of Clinical Hypertension, 2022 The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The calcium channel blockers brand‐name amlodipine and nifedipine with extended‐release formulations demonstrate similar clinical efficacy ...
Hao‐Wei Lee +3 more
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Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
British Journal of Pharmacology, EarlyView., 2023 Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley +1 more source
Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth
Scientific Reports, 2023 Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. Tocolytics are drugs used in cases of imminent preterm birth to inhibit uterine contractions.
Bridget M. Arman +8 more
doaj +1 more source