Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]
, 2017 Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K +7 more
core +2 more sources
Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]
The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm +15 more
core +1 more source
Effect of Gastric Fluid Volume on the in Vitro Dissolution and in Vivo Absorption of BCS Class II Drugs: A Case Study with Nifedipine [PDF]
, 2016 Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients.
Fadda, Hala M. +3 more
core +1 more source
The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor
Clinical and Experimental Obstetrics & Gynecology, 2023 Background: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor.
Huseyin Kiyak +7 more
doaj +1 more source
Comparison of the Efficacy of Nifedipine and Hydralazine in Hypertensive Crisis in Pregnancy [PDF]
Acta Medica Iranica, 2011 Intravenous hydralazine is a commonly administered arteriolar vasodilator that is effective for hypertensive emergencies associated with pregnancy. Oral nifedipine is an alternative in management of these patients.
Yashar Youefzadeh-Fard +6 more
doaj +2 more sources
Study of nifedipine solubility in physical mixtures and solid dispersions
Разработка и регистрация лекарственных средствIntroduction. Poor aqueous solubility significantly hinders the bioavailability of numerous orally administered drugs. Nifedipine, a widely-used cardiovascular agent, is categorized as practically insoluble according to pharmacopoeias, thus presenting a ...
N. J. Dahma +2 more
doaj +1 more source
Obstetrics and Gynecology International, 2010 Objective. Evaluating changes in the power spectral density (PSD) peak frequency of the electrohysterogram (EHG) caused by nifedipine in women with preterm contractions. Methods.
Maartje P. G. C. Vinken +4 more
doaj +1 more source
Nifedipine and indomethacin in preventing preterm labor under 32 gestational weeks
Gülhane Tıp Dergisi, 2022 Aims:This study compared nifedipine and indomethacin treatments, commonly used tocolytic agents, in terms of efficacy and maternal side effects.Methods:This retrospective study included pregnant women spontaneous preterm labor between 24 and 32 weeks of ...
Gülşah Dağdeviren +5 more
doaj +1 more source
PENGARUH PENGGUNAAN NIFEDIPIN PADA PENDERITA HIPERTENSI TERHADAP LAJU ALIRAN SALIVA DAN PEMBESARAN GINGIVA [PDF]
, 2015 Background : The prevalence of hypertension is increasing in society. Nifedipine as one of antihypertensive drugs from Calcium Channel Blocker is the type of drug that is often used . The impact on the oral cavity due to the use of nifedipine in patients
Danniswara, Fadia Ghaisani +1 more
core +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source