Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
AM Evans +23 more
core +3 more sources
Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
British Journal of Pharmacology, EarlyView., 2023 Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley +1 more source
BMC Complementary Medicine and Therapies, 2020 Background We evaluated the long-term cost-effectiveness of antihypertensive traditional Chinese medicines (TCMs) and to compare the cost-effectiveness of a combined treatment consisting of compound Apocynum tablets and Nifedipine sustained-release ...
Qian Xu +5 more
doaj +1 more source
The Inhibitory Effects of Ca2+ Channel Blocker Nifedipine on Rat Kv2.1 Potassium Channels. [PDF]
PLoS ONE, 2015 It is well documented that nifedipine, a commonly used dihydropyridine Ca2+ channel blocker, has also significant interactions with voltage-gated K+ (Kv) channels.
Xian-Tao Li +3 more
doaj +1 more source
Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]
, 1990 A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D +3 more
core +2 more sources
Elucidation of molecular kinetic schemes from macroscopic traces using system identification [PDF]
, 2017 Overall cellular responses to biologically-relevant stimuli are mediated by networks of simpler lower-level processes. Although information about some of these processes can now be obtained by visualizing and recording events at the molecular level, this
Brezina, Vladimir +6 more
core +6 more sources
Photoinduced Removal of Nifedipine Reveals Mechanisms of Calcium Antagonist Action on Single Heart Cells [PDF]
, 1985 The currents through voltage-activated calcium channels in heart cell membranes are suppressed by dihydropyridine calcium antagonists such as nifedipine.
Gurney, Alison M. +2 more
core +2 more sources
Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial
Annals of Family Medicine, 2016 PURPOSE Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial.
I. Souwer +3 more
semanticscholar +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis
Drug Design, Development and Therapy, 2016 Objective The aim of this study was to systematically compare the therapeutic effect and safety of tamsulosin with nifedipine in medical expulsive therapy for distal ureteral calculi. Methods Databases, including PubMed, EMBASE, the Cochrane Library, and
Hai Wang +4 more
semanticscholar +1 more source