Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
, 2006 KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
AM Evans +23 more
core +3 more sources
The Relationship between Nifedipine and Postpartum Blood Loss in Patients with Preterm Labor
Clinical and Experimental Obstetrics & Gynecology, 2023 Background: The purpose of the study, to determine whether exposure to nifedipine before delivery is associated with an increased risk of postpartum blood loss in patients with preterm labor.
Huseyin Kiyak +7 more
doaj +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats
Molecules, 2021 Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff +2 more
doaj +1 more source
Effect of Gastric Fluid Volume on the in Vitro Dissolution and in Vivo Absorption of BCS Class II Drugs: A Case Study with Nifedipine [PDF]
, 2016 Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients.
Fadda, Hala M. +3 more
core +1 more source
Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]
The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm +15 more
core +1 more source
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]
, 2017 Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K +7 more
core +2 more sources
Prognostic Factors of Renal Involvement in Systemic Sclerosis [PDF]
, 2018 Background/Aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was
Barbano, Biagio +5 more
core +2 more sources
Study of nifedipine solubility in physical mixtures and solid dispersions
Разработка и регистрация лекарственных средствIntroduction. Poor aqueous solubility significantly hinders the bioavailability of numerous orally administered drugs. Nifedipine, a widely-used cardiovascular agent, is categorized as practically insoluble according to pharmacopoeias, thus presenting a ...
N. J. Dahma +2 more
doaj +1 more source
Obstetrics and Gynecology International, 2010 Objective. Evaluating changes in the power spectral density (PSD) peak frequency of the electrohysterogram (EHG) caused by nifedipine in women with preterm contractions. Methods.
Maartje P. G. C. Vinken +4 more
doaj +1 more source