Results 71 to 80 of about 3,048,198 (365)

Complying with the NIH Public Access Policy - Copyright Considerations and Options [PDF]

, 2008
On January 11, 2008, the National Institutes of Health ('NIH') adopted a revised Public Access Policy for peer-reviewed journal articles reporting research supported in whole or in part by NIH funds.
Carroll, Michael W.
core   +1 more source

Low agreement among reviewers evaluating the same NIH grant applications

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Scientific grant peer reviewers must differentiate the very best applications from comparatively weaker ones. Despite the importance of this determination in allocating funding, little research has explored how reviewers derive their ...
Elizabeth L. Pier, M. Brauer, Amarette Filut, A. Kaatz, Joshua Raclaw, Mitchell J. Nathan, Cecilia E. Ford, M. Carnes   +7 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

HiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells

Scientific Reports, 2022
DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on traditional microscopy or cytometric methods.
Kelsey Gallant, Arsun Bektas, Mary Kaileh, Ana Lustig, Luigi Ferrucci, Gianluca Pegoraro, Tom Misteli   +6 more
doaj   +1 more source

Electrical stimulation of visual cortex can immediately improve spatial vision [PDF]

, 2016
Published in final edited form as:Curr Biol. 2016 July 25; 26(14): 1867–1872. doi:10.1016/j.cub.2016.05.019.SUMMARY We can improve human vision by correcting the optics of our lenses [1, 2, 3].
McClenahan, Laura J., Reinhart, Robert M.G., Woodman, Geoffrey F., Xiao, Wenxi   +3 more
core   +1 more source

Contribution of NIH funding to new drug approvals 2010–2016

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This report shows that NIH funding contributed to published research associated with every one of the 210 new drugs approved by the Food and Drug Administration from 2010–2016.
Ekaterina Galkina Cleary, J. Beierlein, Navleen Surjit Khanuja, Laura M. McNamee, F. Ledley   +4 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Differential Regulation of T-cell mediated anti-tumor memory and cross-protection against the same tumor in lungs versus skin

OncoImmunology, 2018
A major advantage of immunotherapy of cancer is that effector cells induced at one site should be able to kill metastatic cancer cells in other sites or tissues.
Jessica J. O'Konek, Elena Ambrosino, Anja C. Bloom, Lise Pasquet, Chandirasegaran Massilamany, Zheng Xia, Masaki Terabe, Jay A. Berzofsky   +7 more
doaj   +1 more source

Innovative approaches to the study of social phenotypes in neurodevelopmental disorders: an introduction to the research topic [PDF]

, 2013
R01 HD033470 - NICHD NIH ...
Plesa Skwerer, Daniela, Tager-Flusberg, Helen   +1 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source