Results 91 to 100 of about 1,396 (170)

Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging. [PDF]

, 2019
OBJECTIVE:Nitisinone induced hypertyrosinaemia is a concern in patients with Alkaptonuria (AKU). It has been suggested that this may alter neurotransmitter metabolism, specifically dopamine and serotonin.
Hughes, AT, Gallagher, JA, Milan, AM, Goodwin, RJA, Hughes, J, Sutherland, H, Davison, Andrew S, Bou-Gharios, G, Strittmatter, N, Ranganath, LR   +9 more
core   +1 more source

Alkaptonuria: Current Perspectives

The Application of Clinical Genetics, 2020
Andrea Zatkova,1 Lakshminarayan Ranganath,2 Ludevit Kadasi1,3 1Department of Human Genetics, Biomedical Research Center, Slovak Academy of Sciences, Institute of Clinical and Translational Research, Bratislava, Slovakia; 2National Alkaptonuria Centre ...
Zatkova A, Ranganath L, Kadasi L
doaj  

Simultaneous quantification of succinylacetone and nitisinone for therapeutic drug monitoring in the treatment of Tyrosinemia type 1

, 2018
We present a straightforward and robust method for simultaneous quantification of succinylacetone and nitisinone in plasma using LC-ESI–MS/MS. The method has been developed for routine therapeutic drug monitoring in hepatorenal tyrosinemia type 1 (HT1 ...
Allan Meldgaard Lund, Wibrand, Flemming, Jonas Sundberg, Flemming Wibrand, Sundberg, Jonas, Christensen, Mette, Mette Christensen, Lund, Allan Meldgaard   +7 more
core   +1 more source

Metabolomic changes associated with acquired resistance to Ixodes scapularis

Ticks and Tick-Borne Diseases
Guinea pigs repeatedly exposed to Ixodes scapularis develop acquired resistance to the ticks (ATR). The molecular mechanisms of ATR have not been fully elucidated, and partially involves immune responses to proteins in tick saliva.
Yingjun Cui, Jaqueline Matias, Xiaotian Tang, Balasubramanian Cibichakravarthy, Kathleen DePonte, Ming-Jie Wu, Erol Fikrig   +6 more
doaj   +1 more source

Behavioral and intellectual functioning in patients with tyrosinemia type I [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2012
Introduction: In tyrosinemia type I (TT1) increased level of tyrosine and phenylalanine (both precursors of neurotransmitters), may potentially influence patients’ cognitive development.
Agnieszka Kowalik, Katarzyna Kuśmierska, Marcin Biernacki, Anna Jakubowska-Winecka, Marta Biernacka, Monika Pohorecka, Jolanta Sykut-Cegielska   +6 more
doaj  

Nitisinone

Drugs in R & D, 2002
openaire   +2 more sources

Comment on: Evaluating the impact of nitisinone at mosquito-lethal doses on Lutzomyia longipalpis. [PDF]

PLoS Negl Trop Dis
Hawkins K, Haines LR, Acosta-Serrano Á.
europepmc   +1 more source

Response to comment on: Evaluating the impact of nitisinone at mosquito-lethal doses on Lutzomyia longipalpis. [PDF]

PLoS Negl Trop Dis
Augendre L, Farias de Souza LA, da Costa Ribeiro MCV, Depaquit J, Martinet JP, Prudhomme J.   +5 more
europepmc   +1 more source

Plasma Proteomic Signatures in Alkaptonuria. [PDF]

Biology (Basel)
Finetti R, Visibelli A, Roncaglia B, Trezza A, Peruzzi L, Marzocchi B, Spiga O, Cicogni M, Salvini L, Tinti L, Cicaloni V, Cheleschi S, Rossi M, Tinti C, Santucci A.   +14 more
europepmc   +1 more source

When two rare diseases meet: atypical hemolytic uremic syndrome and alkaptonuria in two siblings. [PDF]

CEN Case Rep
Karaca C, Karatas B, Tunc R, Erdem M, Dincer MT, Mirioglu S.   +5 more
europepmc   +1 more source