Conversion of Squid Pen to Homogentisic Acid via Paenibacillus sp. TKU036 and the Antioxidant and Anti-Inflammatory Activities of Homogentisic Acid [PDF]
Marine Drugs, 2016 The culture supernatant of Paenibacillus sp. TKU036, a bacterium isolated from Taiwanese soils, showed high antioxidant activity (85%) when cultured in a squid pen powder (SPP)-containing medium at 37 °C for three days.
San-Lang Wang +4 more
doaj +7 more sources
Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages [PDF]
Nature Communications, 2019 The ability to image macrophages in vivo would provide insights into homeostasis and disease but current imaging agents have effects on viability and functionality.
Ina Weidenfeld +7 more
doaj +2 more sources
Cardiovascular involvement in Alcaptonuria: a case report on ochronotic aortic valve [PDF]
Journal of Cardiothoracic SurgeryAlcaptonuria is a rare autosomal recessive metabolic disorder. It is characterized by the accumulation of homogentisic acid–derived brown and bluish-black pigments in connective tissues, a condition known as ochronosis. This occurs due to a defect in the
Alizamin Yusifli +5 more
doaj +2 more sources
Homogentisic Acid and Gentisic Acid Biosynthesized Pyomelanin Mimics: Structural Characterization and Antioxidant Activity [PDF]
International Journal of Molecular Sciences, 2021 Rebecca Pogni +2 more
exaly +2 more sources
Ochronotic Arthropathy of the Shoulder – A Rare Case Report [PDF]
Journal of Orthopaedic Case ReportsIntroduction: Alkaptonuria is a metabolic disorder due to accumulation of homogentisic acid, leading to destruction of major joints. Very few cases of ochronosis with shoulder involvement have been reported in literature. Case Report: We report a 31-year-
Ayyappan V Nair +5 more
doaj +2 more sources
A Yarrowia lipolytica Strain Engineered for Pyomelanin Production
Microorganisms, 2021 The yeast Yarrowia lipolytica naturally produces pyomelanin. This pigment accumulates in the extracellular environment following the autoxidation and polymerization of homogentisic acid, a metabolite derived from aromatic amino acids.
Macarena Larroude +4 more
doaj +1 more source
Ophthalmological Manifestations of Alkaptonuria
Oftalʹmologiâ, 2022 Alkaptonuria is rare autosomal recessive multisystem disease, caused by mutations in the homogentisine oxidase gene, which leads to the deposition of metabolites of homogentisic acid in organs and tissues (ochronosis).The purpose: to study spectrum of ...
E. V. Denisova, A. V. Kuzin
doaj +1 more source
Journal of Orthopaedic Reports, 2023 Background: Ochronotic Arthropathy is very rare disorder (around one in million people). It is due to deficiency of enzyme homogentisic acid oxidase which leads to accumulation of homogentisic acid (HGA) and causes damage of several connective tissues ...
Sanjeev Jain, Sabeel Ahmad, K. Vishwas
doaj +1 more source
Long-term follow-up of bilateral hip and knee arthroplasty secondary to ochronotic arthropathy
Arthroplasty Today, 2020 Alkaptonuria is a rare metabolic disorder caused by the deficiency of homogentisic acid oxidase enzyme, which is responsible for eliminating homogentisic acid from the body through the renal system.
Imran Ilyas, MD +5 more
doaj +1 more source
Bilateral Breast Ochronosis: a Case Report
JPRAS Open, 2021 : Ochronosis is a syndrome characterized by bluish black discoloration due to the deposition of polymerized products of homogentisic acid (HGA) in the connective tissues.
Fatema A.J. AbdulKarim +3 more
doaj +1 more source