Results 41 to 50 of about 2,687,981 (207)

Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria [PDF]

, 2022
Alkaptonuria (AKU) is an ultra-rare genetic disease caused by a deficient activity of the enzyme homogentisate 1,2-dioxygenase (HGD) leading to the accumulation of homogentisic acid (HGA) on connective tissues. Even though AKU is a multi-systemic disease,
Tinti, Laura, Rossi, Ranieri, Spiga, Ottavia, Prischi, Filippo, Milella, Maria Serena, Bernardini, Giulia, Rossi, Martina, Millucci, Lia, Giustarini, Daniela, Tinti, Cristina, Braconi, Daniela, Prischi, Filippo; id_orcid, Santucci, Annalisa, Cicaloni, Vittoria, Salvini, Laura, Galderisi, Silvia, Lupetti, Pietro, Millucci L., Bernardini G., Rossi R., Tinti L., Salvini L., Giustarini D., Braconi D., Cicaloni V., Lupetti P., Rossi M., Milella M. S., Tinti C., Galderisi S., Santucci A., Spiga O., Prischi F., Ottavia Spiga, Ranieri Rossi, Laura Tinti, Filippo Prischi, Daniela Giustarini, Martina Rossi, Laura Salvini, Annalisa Santucci, Silvia Galderisi, Vittoria Cicaloni, Maria Serena Milella, Daniela Braconi, Pietro Lupetti, Giulia Bernardini, Lia Millucci, Cristina Tinti   +48 more
core   +3 more sources

Scavenging Ability of Homogentisic Acid and Ergosterol toward Free Radicals Derived from Ethanol Consumption

, 2018
Acute, or chronic, ethanol consumption leads to the formation of free radicals in the liver, which is related to hepatic damage. Among these radicals 1-hydroxyethyl, •CH­(OH)­CH3, is the most abundant one.
Manuel E. Medina (2897231), Annia Galano (1390411), Ángel Trigos (2897228)   +2 more
core   +1 more source

Sodium Hypochlorite Pentahydrate in Organic Synthesis and Beyond

Chemistry–Methods, Volume 6, Issue 10, October 2026.
Sodium hypochlorite pentahydrate emerges as a versatile, stable, and practical oxidant for organic synthesis. This review highlights its unique reactivity, broad synthetic applications, and growing impact on sustainable oxidation chemistry, providing a comprehensive overview of recent advances and future opportunities. Sodium hypochlorite pentahydrate (
Masayuki Kirihara, Hideyuki Tsutsui, Yoshikazu Kimura   +2 more
wiley   +1 more source

Polyphenol‐Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
A 12‐week nutritional intervention with cocoa flavanols and red‐berry anthocyanins in older adults improved emotional well‐being and identified metabolomic signatures associated with the intervention through urinary metabolome profiling. ABSTRACT The so‑called demographic transition has increased the prevalence of chronic diseases in adults over 65 ...
María Lucía Gómez Nieto, Verónica Puertas‐Martín, Susana Chamorro, Antonio Méndez‐Guerrero, Inmaculada Álvarez‐Acero, Claudia Balderas, Sonia de Pascual‐Teresa   +6 more
wiley   +1 more source

Study of the Oxidation Behavior of Tyrosine Using Electrochemistry, Capillary Electrophoresis, and Mass Spectrometry

Electroanalysis, Volume 38, Issue 5, May 2026.
Online electrochemistry with mass spectrometry, followed by a combination of these two techniques with capillary electrophoresis as a strong separation technique in between, is used to study the oxidation behavior of L‐tyrosine at a neutral pH value to suggest possible electrogenerated products on the surface of a carbon‐based screen‐printed electrode.
Seyedehelahe Bagherimetkazini, Frank‐Michael Matysik   +1 more
wiley   +1 more source

Promoting Corn Stover Degradation via Sequential Processing of Steam Explosion and Lactic Acid Bacteria‐Assisted Ensilage

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT Efficient utilization of corn stover is essential for enhancing the sustainability of livestock feed. However, its high lignocellulose content limits digestibility and nutritional value. Steam explosion technology, an emerging pretreatment method, has shown promise in food processing for its ability to break down the natural structural ...
Xuejiao Yin, Yuchun Xie, Jiqiao Xia, Yahui Liang, Tao Jia, Kexin Qian, Chao Wang, Mingyue Li, Yaozhi Zhang, Fangxiang Wu, Junping Feng, Li Zhang, Chenghao Ji, Kexing Hao, Yong Wang, Changqing Li   +15 more
wiley   +1 more source

A century of vitamin E research: The innovative journey from basic biology to synthetic bio‐manufacturing

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 985-1012, April 2026.
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Ruiqi Zhang, Yuqing Ren, Yuehe Zhao, Hongyan Zheng, Yanzhong Luo, Yuan Liu, Lei Wang, Lan Zhang   +7 more
wiley   +1 more source

Solubilized melanin suppresses macrophage function

FEBS Open Bio, 2019
Melanin‐producing Cryptococcus and Aspergillus are highly invasive and can suppress or escape the immune system of the host. Since non‐melanin‐producing strains do not affect the immune system, melanin may play a role in immune system suppression ...
Katsuya Tajima, Daisuke Yamanaka, Ken‐ichi Ishibashi, Yoshiyuki Adachi, Naohito Ohno   +4 more
doaj   +1 more source

Pursuit of Osler's sign

TNOA Journal of Ophthalmic Science and Research, 2021
A 58-year-old male came to the ophthalmology outpatient department with complaints of blackish discoloration in both eyes, which he noticed 6 months back.
Suriya Djeamourthy, Sarala Sankar, Veni Priya Sigamani, Renuka Srinivasan   +3 more
doaj   +1 more source

Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage [PDF]

, 2021
Alkaptonuria (AKU) is an ultra-rare disease caused by the deficient activity of homogentisate 1,2-dioxygenase enzyme, leading the accumulation of homogentisic acid (HGA) in connective tissues implicating the formation of a black pigmentation called ...
Millucci L., Milella M. S., Tinti C., Galderisi S., Alves L. S., Tinti L., Vieira O. V., Geminiani M., Salvini L., Santucci A., Spiga O., Cicaloni V., Crevenna A. H.   +12 more
core   +1 more source