Results 61 to 70 of about 2,511,484 (202)
Oman Medical Journal, 2013 Ochronotic arthropathy is a manifestation of longstanding alkaptonuria. With increasing age, an accumulation of pigment deposits of homogentisic acid in the joint cartilage results in ochronotic osteoarthritis.
Mehmet Ali Acar +5 more
doaj +1 more source
The Dibromination of Homogentisic Acid Lactone
, 2014 The recently described total synthetic pathway to clavatadine A, beneficial for its properties as an anticoagulant, is hindered by a step involving the dibromination of homogentisic acid lactone.
Bouchey, Sydney +3 more
core +1 more source
Alkaptonuria in a 6 Year Old Patient: Case Report
Urology Case Reports, 2015 Alkaptonuria is a rare disorder of tyrosine catabolism. A 6 year old male child presented with history of darkish staining of the toilet commode following voiding. The urine when kept in a sterile container for a few hours turned black. Urine examination
Vikas Sharma +4 more
doaj +1 more source
Advanced Science, Volume 12, Issue 30, August 14, 2025.HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie +21 more
wiley +1 more source
BiomedicinesChronic kidney disease (CKD) affects approximately 12% of the global population, posing a significant health threat. Inflammation plays a crucial role in the uremic phenotype of non-dialysis-dependent (NDD) stage 5 CKD, contributing to elevated ...
María Peris-Fernández +8 more
doaj +1 more source
Annals of Agricultural and Environmental Medicine, 2015 [b][/b][b]Introduction[/b]. Alzheimer’s disease is a progressively developing neurodegenerative disorder of the central nervous system. The only present treatment of this disease is the use of acetyl- and butyrylcholinesterase inhibitors. Previously, the
Dominik Szwajgier
doaj +1 more source
First Insights Into the LC‐HRMS Profiling and Biological Activities of Crocus graveolens
Food Science &Nutrition, Volume 13, Issue 8, August 2025.This study reports the first comprehensive analysis of Crocus graveolens Boiss. & Reut. using LC‐HRMS, identifying 33 secondary metabolites, with rutin as the major compound (162.808 ± 4.5 μg/g extract). The extract showed moderate antioxidant activity and effectively inhibited acetylcholinesterase (30.88% ± 1.51%) and butyrylcholinesterase (61.22% ± 0.
Ezgi Ersoy +5 more
wiley +1 more source
Determination of Peroxidase Encapsulated in Liposomes Using Homogentisic Acid .GAMMA.-Lactone Chemiluminescence [PDF]
, 2005 Homogentisic acid γ-lactone (HAL) chemiluminescence (CL) was applied to the determination of horseradish peroxidase (HRP) encapsulated in liposomes. HRP was detected after the lysis of HRP-trapped liposomes with Triton X-100.
TANI, Hirofumi +3 more
core +1 more source
КардиоСоматикаBACKGROUND: Ochronosis is a rare disorder caused by an inherited defect in tyrosine metabolism, in which the biochemical degradation pathway is interrupted at the stage of homogentisic acid formation.
Amina M. Alieva +6 more
doaj +1 more source
Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects [PDF]
, 2008 A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology.
Bajor, Antal
core +1 more source