Results 81 to 90 of about 2,511,484 (202)

Ease of sutureless aortic valve replacement in a patient with unexpected ochronosis: a case report

Journal of Cardiothoracic Surgery
Background Alkaptonuria is a rare congenital metabolic disorder characterized by homogentisic acid accumulation in body cartilage and connective tissues due to a deficient homogentisic acid dioxygenase enzyme.
Saeid Hosseini, Soheila Salari, Mohammad Javad Alemzadeh Ansari, Mahshid Hesami, Sepideh Banar, Mohammad Amin Shojaei   +5 more
doaj   +1 more source

Identification and application of herbicide‐resistant 4‐hydroxyphenylpyruvate dioxygenase (HPPD) alleles via directed evolution

Plant Biotechnology Journal, Volume 23, Issue 10, Page 4336-4338, October 2025.
Bingbing Zhao, Yao Wang, Miaoyi Zhou, Xinxiang Liu, Hanshuai Li, Zi Shi, Yuhui Guo, Ting Li, Fengling Yang, Ronghuan Wang, Jiuran Zhao, Ya Liu   +11 more
wiley   +1 more source

Discovery of Homogentisic Acid as a Precursor in Trimethoprim Metabolism and Natural Product Biosynthesis. [PDF]

ACS Chem Biol, 2023
McAvoy AC, Threatt PH, Kapcia J, Garg N.
europepmc   +1 more source

In vitro polymerization of homogentisic acid as a model system to enable understanding of pyomelanin in vivo

, 2021
The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients.
Taylor, Adam, Galeb, Hanaa, Hardy, John
core   +2 more sources

No silver lining with health misinformation: argyria caused by intentional silver consumption

Medical Journal of Australia, Volume 223, Issue 2, Page 68-70, July 2025.
Luke Collins, Logesh Palanikumar, Stephen Bacchi   +2 more
wiley   +1 more source

Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway

, 2020
Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation.
Millucci L., Schiavone M. L., Santucci A., Marzocchi B., Bernardini G., Giustarini D., Rossi R.   +6 more
core   +1 more source

Cytotoxic activity of strawberry tree (Arbutus unedo L.) honey, its extract, and homogentisic acid on CAL 27, HepG2, and Caco-2 cell lines. [PDF]

Arh Hig Rada Toksikol, 2022
Jurič A, Huđek Turković A, Brčić Karačonji I, Prđun S, Bubalo D, Durgo K.   +5 more
europepmc   +1 more source

Clinical Images: Stubborn low back pain under the eyes

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
William Gil, Martin Soubrier
wiley   +1 more source

Determination of homogentisic acid using HPLC with amperometric detection at carbon paste electrodes [PDF]

, 2017
Homogentisic acid is an intermediate of the metabolic breakdown of tyrosine and phenylalanine; its accumulation in body fluids suggests the break in the metabolic pathway of these compounds and related health-threatening complications.
Lozano Alonso, María
core  

Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation. [PDF]

JIMD Rep, 2021
Wilson PJM, Ranganath LR, Bou-Gharios G, Gallagher JA, Hughes JH.   +4 more
europepmc   +1 more source