Results 91 to 100 of about 2,687,981 (207)

Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation. [PDF]

JIMD Rep, 2021
Wilson PJM, Ranganath LR, Bou-Gharios G, Gallagher JA, Hughes JH.   +4 more
europepmc   +1 more source

In vitro polymerization of homogentisic acid as a model system to enable understanding of pyomelanin in vivo

, 2021
The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients.
Taylor, Adam, Galeb, Hanaa, Hardy, John
core  

Alkaptonuria: A case report

, 2001
Alkaptonuria is a rare, autosomally recessive, metabolic disorder caused by a deficiency in homogentisic acid oxidase. It results in accumulation and deposition of homogentisic acid in cartilage, eyelids, forehead, cheeks, axillae, genital regions, nail ...
Cetinkaya, R, Odabas, AR, Erdem, T, Karakuzu, A, Selcuk, Y   +4 more
core   +1 more source

Cytotoxicity of Active Ingredients Extracted from Plants of the Brazilian “Cerrado”

Natural Product Communications, 2011
Cytotoxicity assays are needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian “cerrado”.
Veronica CG Soares, Cibele Bonacorsi, Alana LB Andrela, Lígia V Bortoloti, Stepheny C de Campos, Fábio HR Fagundes, Márcio Piovani, Camila A Cotrim, Wagner Vilegas, Marcos H Toyama   +9 more
doaj   +1 more source

Observations on the oxidation of homogentisic acid in urine [PDF]

Biochemical Journal, 1951
R, CONSDEN, H A W, FORBES, L E, GLYNN, W M, STANIER   +3 more
openaire   +2 more sources

Simplified tocopherol biosynthetic pathway [1], [16], [17].

, 2012
The three tocopherol compounds measured in this study (red) and the key genes involved in this process (blue) are shown. DMPBQ, 2,3-dimethyl-5-phytyl-1,4-benzoquinone; GGDP, geranylgeranyl diphosphate; HGA, homogentisic acid; HGGT, homogentisic acid ...
Shutu Xu (164868), Dalong Zhang (164879), Xiaohong Yang (109367), Lin Li (28817), Shibin Gao (164894), Qing Li (84975), Jiansheng Li (109370), Jianbing Yan (109373), Yingjia Han (164883), Ye Cai (164874), Zuxin Zhang (164890)   +10 more
core   +1 more source

Assessment of mass spectrometric indicators of organic acids metabolism in children with sarcopenia on the background of protein-energy insufficiency. Pilot study

Acta Biomedica Scientifica
Introduction. The geriatric problem of sarcopenia is relevant for both therapists and pediatricians. Secondary sarcopenia is diagnosed at any age in severe diseases, as well as muscle loss and muscle strength due to protein-energy malnutrition (PEM) or ...
V. P. Novikova, A. N. Zavyalova, M. N. Yakovleva, E. L. Strukov, I. V. Kukes, T. D. Lunegov   +5 more
doaj   +1 more source

Brown Pigments Produced by Yarrowia lipolytica Result from Extracellular Accumulation of Homogentisic Acid

, 2001
Yarrowia lipolytica produces brown extracellular pigments that correlate with tyrosine catabolism. During tyrosine depletion, the yeast accumulated homogentisic acid, p -hydroxyphenylethanol, and p
Alexandra Carreira, Luı́sa M. Ferreira, Virgı́lio Loureiro   +2 more
core   +1 more source

Determination of homogentisic acid in urine for diagnosis of alcaptonuria: Capillary electrophoretic method optimization using experimental design

, 2018
Homogentisic acid (HGA) is a diagnostic metabolite that accumulates in the urine and tissues of patients with alkaptonuria which is a rare autosomal recessive disease.
Balta, Gulfem S., Gülfem S. Balta, Öztekin, Nevin, M. Şerif Cansever, Cansever, M. Serif, Nevin Öztekin, Cansever, Mehmet Şerif   +6 more
core   +1 more source

Primer reporte de alcaptonuria en el Perú

Revista Peruana de Medicina Experimental y Salud Pública
La alcaptonuria es un error innato del metabolismo causado por la deficiencia de la homogentisiato 1,2 dioxidasa (HGD), produciéndose un exceso de ácido homogentísico (HGA).
Daniel Guillén-Mendoza, María Quiroga de Michelena   +1 more
doaj