Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial. [PDF]
Cells, 2023 Ooi N +7 more
europepmc +1 more source
Knee degenerative osteoarthritis secondary to ochronosis (case report)
Travmatologiâ i Ortopediâ Rossii, 2013 Alkaptonuria is rare disease with deficiency of homogentisate-1,2-dioxygenase enzyme, resulting in excess deposition of homogentisic acid in connective tissue. This deposition leads to ochronosis - brownish-black pigmentation of connective tissue.
V. V. Bliznyukov +2 more
doaj +1 more source
Cytotoxic activity of strawberry tree (Arbutus unedo L.) honey, its extract, and homogentisic acid on CAL 27, HepG2, and Caco-2 cell lines. [PDF]
Arh Hig Rada Toksikol, 2022 Jurič A +5 more
europepmc +1 more source
Endogenous ochronosis with keratoelastoidosis marginalis
Indian Journal of Dermatopathology and Diagnostic Dermatology, 2019 Endogenous ochronosis is a manifestation of alkaptonuria, a rare metabolic disease due to homogentisic acid oxidase deficiency. Darkened urine and arthropathy are the other two components that complete the triad of alkaptonuria. Pigmentation of skin, the
R Mythreyi +4 more
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Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017 Alkaptonuria (AKU) is an ultra-rare inborn error of metabolism characterized by homogentisic acid (HGA) accumulation due to a deficient activity of the homogentisate 1.2-dioxygenase (HGD) enzyme. This leads to the production of dark pigments that are deposited onto connective tissues, a condition named 'ochronosis' and whose mechanisms are not ...
BRACONI, DANIELA +8 more
openaire +3 more sources
Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation. [PDF]
JIMD Rep, 2021 Wilson PJM +4 more
europepmc +1 more source
Cytotoxicity of Active Ingredients Extracted from Plants of the Brazilian “Cerrado”
Natural Product Communications, 2011 Cytotoxicity assays are needed for the screening of natural products with potential anti-inflammatory. The purpose of this study was to compare the basal cytotoxicity of active ingredients extracted from plants of the Brazilian “cerrado”.
Veronica CG Soares +9 more
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Arthroplasty for the treatment of joint degeneration caused by ochronosis in two cases
Acta Orthopaedica et Traumatologica Turcica, 2020 Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. With increasing age, accumulation of pigment deposits of homogentisic acid in the joint cartilage results in ochronotic osteoarthritis.
Mehmet Kefeli +3 more
doaj
Acta Biomedica ScientificaIntroduction. The geriatric problem of sarcopenia is relevant for both therapists and pediatricians. Secondary sarcopenia is diagnosed at any age in severe diseases, as well as muscle loss and muscle strength due to protein-energy malnutrition (PEM) or ...
V. P. Novikova +5 more
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The oxidation of ascorbic acid and its reduction in vitro and in vivo [PDF]
, 1937 The outstanding chemical property of ascorbic acid (vitamin C) is that it is a reducing agent. The suggestion is obvious that its physiological function may be associated with this property, and, if it is oxidized reversibly, with its behavior in an ...
Borsook, Henry +3 more
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