Results 71 to 80 of about 2,687,981 (207)

Homogentisic Acid: A Phenolic Acid as a Marker of Strawberry-Tree (Arbutus unedo L.) Honey

, 1999
Analysis of organic acids in strawberry-tree (Arbutus unedo) honey showed the presence of an unknown acid as the main constituent. This compound was isolated and identified as homogentisic acid (2,5-dihydroxyphenylacetic acid) by MS and NMR techniques ...
Guillou C, Ghelli S., Tuberoso C, Angioni A, Cabras P, FLORIS, Ignazio, Reniero F   +6 more
core  

Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway

, 2020
Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation.
Millucci L., Schiavone M. L., Santucci A., Marzocchi B., Bernardini G., Giustarini D., Rossi R., Maria Lucia Schiavone, Lia Millucci, Daniela Giustarini, Ranieri Rossi, Annalisa Santucci, Giulia Bernardini, Barbara Marzocchi   +13 more
core   +1 more source

Ochronotic arthropathy: skeletal manifestations and orthopaedic treatment

EFORT Open Reviews
Alkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage.
Khaled Hamed Salem, Alyaa Diaa Elmoghazy
doaj   +1 more source

Production and Bioactivity-Guided Isolation of Antioxidants with α-Glucosidase Inhibitory and Anti-NO Properties from Marine Chitinous Materials

Molecules, 2018
Natural and bioactive products have been of great interest due to their benefit as health foods and drugs to prevent various diseases. The aim of this study is to efficiently reuse marine chitinous materials (CMs), abundant and low-cost fishery by ...
Van Bon Nguyen, Thi Hanh Nguyen, Chien Thang Doan, Thi Ngoc Tran, Anh Dzung Nguyen, Yao-Haur Kuo, San-Lang Wang   +6 more
doaj   +1 more source

Ochronotic arthropathy of the hip with multiple joint involvement: a rare case report and literature review [PDF]

The Egyptian Orthopaedic Journal
Ochronosis is a rare inherited genetic disorder that affects tyrosine and phenylalanine metabolism. It leads to the deposition of dark pigments in connective tissues and articular cartilage, which are rich in collagen.
Plaban N. Chowdhury, Abhishek Vaish, Pankaj Baweja, Raju Vaishya   +3 more
doaj   +1 more source

The Dibromination of Homogentisic Acid Lactone

, 2014
The recently described total synthetic pathway to clavatadine A, beneficial for its properties as an anticoagulant, is hindered by a step involving the dibromination of homogentisic acid lactone.
Bouchey, Sydney, Maverick, Rebecca, Calaway, Austin, Chamberland, Stephen   +3 more
core  

Expanding the Interface: Overlooked Dermatologic Disorders With Ocular Involvement

JEADV Clinical Practice, Volume 4, Issue 5, Page 1239-1243, December 2025.
A George
wiley   +1 more source

Ochronotic Arthropathy of the Knee: A Case Report

Orthopaedic Journal of Sports Medicine
Alkaptonuria (AKU) is a low-prevalence genetic inherited disease expressed in an autosomal recessive and monogenic manner, characterized by a tissue accumulation of homogentisic acid (HGA).
MARZO NUNES SANTOS, RICARDO DAVID COUTO, DANIELE BRUSTOLIM   +2 more
doaj   +1 more source

Alkaptonuria: A case report

Indian Journal of Ophthalmology, 2017
Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase. It results in accumulation of homogentisic acid in connective tissues (ochronosis). Most common ocular manifestations
Nirupama Damarla, Prathima Linga, Mallika Goyal, Sanjay Reddy Tadisina, G Satyanarayana Reddy, Hymavathi Bommisetti   +5 more
doaj   +1 more source

Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a Vanuatu marine sponge Pseudoceratina sp. [PDF]

, 2009
As part of our search for new antimalarial drugs in South Pacific marine sponges, we have looked for inhibitors of Pfnek-1, a specific protein kinase of Plasmodium falciparum.
Dominique Laurent, Parenty, A., Lebouvier, Nicolas, Dominique Dorin-Semblat, Doerig, C., Séverine Maurel, Laurent, D., Lebouvier, N., Maurel, Séverine, Valérie Jullian, Sauvain, M., Michel Sauvain, Arnaud Parenty, Sauvain, Michel, Desvignes, Isabelle, Jullian, Valérie, Desvignes, I., Dorin-Semblat, Dominique, Doerig, Christian, Laurent, Dominique, Nicolas Lebouvier, Maurel, S., Dorin-Semblat, D., Christian Doerig, Jullian, V., Isabelle Desvignes, Parenty, Arnaud   +26 more
core   +2 more sources