Results 51 to 60 of about 3,728 (176)

Uremic Toxins and Inflammation: Metabolic Pathways Affected in Non-Dialysis-Dependent Stage 5 Chronic Kidney Disease

Biomedicines
Chronic kidney disease (CKD) affects approximately 12% of the global population, posing a significant health threat. Inflammation plays a crucial role in the uremic phenotype of non-dialysis-dependent (NDD) stage 5 CKD, contributing to elevated ...
María Peris-Fernández, Marta Roca-Marugán, Julià L. Amengual, Ángel Balaguer-Timor, Iris Viejo-Boyano, Amparo Soldevila-Orient, Ramon Devesa-Such, Pilar Sánchez-Pérez, Julio Hernández-Jaras   +8 more
doaj   +1 more source

Alkaptonuria in a 6 Year Old Patient: Case Report

Urology Case Reports, 2015
Alkaptonuria is a rare disorder of tyrosine catabolism. A 6 year old male child presented with history of darkish staining of the toilet commode following voiding. The urine when kept in a sterile container for a few hours turned black. Urine examination
Vikas Sharma, Rajendra B. Nerli, Prasad V. Magdum, Abhijith Mudegoudra, Murigendra B. Hiremath   +4 more
doaj   +1 more source

Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions

Annals of Agricultural and Environmental Medicine, 2015
[b][/b][b]Introduction[/b]. Alzheimer’s disease is a progressively developing neurodegenerative disorder of the central nervous system. The only present treatment of this disease is the use of acetyl- and butyrylcholinesterase inhibitors. Previously, the
Dominik Szwajgier
doaj   +1 more source

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram, Nasir A. Ibrahim, Muhammad Tayyab Arshad, Abroo Fatima, Ali Asghar Taseer, Mahreen Faqeer Hussain, Zunair Abdullah, Nosiba S. Basher, Muhammed Adem Abdullahi, Ammar AL‐Farga, Mohammed Ali Al‐Duais   +10 more
wiley   +1 more source

Ochronotic arthropathy: skeletal manifestations and orthopaedic treatment

EFORT Open Reviews
Alkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage.
Khaled Hamed Salem, Alyaa Diaa Elmoghazy
doaj   +1 more source

Expanding the Interface: Overlooked Dermatologic Disorders With Ocular Involvement

JEADV Clinical Practice, Volume 4, Issue 5, Page 1239-1243, December 2025.
A George
wiley   +1 more source

A clinical case of ochronosis with involvement of the cardiac valvular apparatus and the musculoskeletal system in an 80-year-old patient

КардиоСоматика
BACKGROUND: Ochronosis is a rare disorder caused by an inherited defect in tyrosine metabolism, in which the biochemical degradation pathway is interrupted at the stage of homogentisic acid formation.
Amina M. Alieva, Irina V. Kovtyukh, Irina E. Baykova, Elvira A. Khachirova, Albina B. Sultangalieva, Alexander A. Melnikov, Igor G. Nikitin   +6 more
doaj   +1 more source

Ochronotic Arthropathy of the Knee: A Case Report

Orthopaedic Journal of Sports Medicine
Alkaptonuria (AKU) is a low-prevalence genetic inherited disease expressed in an autosomal recessive and monogenic manner, characterized by a tissue accumulation of homogentisic acid (HGA).
MARZO NUNES SANTOS, RICARDO DAVID COUTO, DANIELE BRUSTOLIM   +2 more
doaj   +1 more source

Ease of sutureless aortic valve replacement in a patient with unexpected ochronosis: a case report

Journal of Cardiothoracic Surgery
Background Alkaptonuria is a rare congenital metabolic disorder characterized by homogentisic acid accumulation in body cartilage and connective tissues due to a deficient homogentisic acid dioxygenase enzyme.
Saeid Hosseini, Soheila Salari, Mohammad Javad Alemzadeh Ansari, Mahshid Hesami, Sepideh Banar, Mohammad Amin Shojaei   +5 more
doaj   +1 more source

Alkaptonuria: A case report

Indian Journal of Ophthalmology, 2017
Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase. It results in accumulation of homogentisic acid in connective tissues (ochronosis). Most common ocular manifestations
Nirupama Damarla, Prathima Linga, Mallika Goyal, Sanjay Reddy Tadisina, G Satyanarayana Reddy, Hymavathi Bommisetti   +5 more
doaj   +1 more source