Results 21 to 30 of about 2,511,484 (202)
Lower urinary tract symptoms and prostatic calculi: A rare presentation of alkaptonuria
Indian Journal of Urology, 2012 Alkaptonuria is a rare tyrosine metabolic disorder. A deficiency of homogentisic acid oxidase leads to accumulation of homogentisic acid in the body. Dark-colored urine, cutaneous pigmentations and musculoskeletal deformities are characteristic features.
F K Sridhar +3 more
doaj +1 more source
Journal of Wood Science, 2021 We conducted our research with the aim of determining whether the “egumi” taste of moso-bamboo shoots differs depending on the production area and how the “egumi” taste of bamboo shoots from Yamagata Prefecture, which is near the northern limit of ...
Yuka Furusawa +2 more
doaj +1 more source
The formation of homogentisate in the biosynthesis of tocopherol and plastoquinone in spinach chloroplasts [PDF]
, 1982 Homogentisate is the precursor in the biosynthesis of -tocopherol and plastoquinone-9 in chloroplasts. It is formed of 4-hydroxyphenylpyruvate of the shikimate pathway by the 4-hydroxyphenylpyruvate dioxygenase.
Soll, Jürgen +5 more
core +1 more source
Long-term result of arthroplasty in the treatment of a case of ochronotic arthropathy
Acta Orthopaedica et Traumatologica Turcica, 2016 Alkaptonuria is a rare metabolic disease caused by a partial or total deficiency of homogentisic acid oxidase, which results in excess homogentisic acid (HGA) levels.
Sinan Karaoğlu +2 more
doaj +1 more source
Determination of Homogentisic Acid in Urine
Clinical Chemistry, 1965 Abstract A relatively simple method for the quantitative determination of homogentisic acid in urine is presented. Homogentisic acid (2,5-dihydroxyphenylacetic acid) is oxidized by atmospheric oxygen in mild alkali to form 1,4-benzoquinone-2-acetic acid. The latter compound is then conjugated with 2,4-dinitrophenylhydrazine.
R E, Stoner, B, Blivaiss
openaire +2 more sources
Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila
BMC Microbiology, 2017 Background Combining experimental and computational screening methods has been of keen interest in drug discovery. In the present study, we developed an efficient screening method that has been used to screen 2100 small-molecule compounds for alanine ...
Yaping Wang +7 more
doaj +1 more source
Case Report: Ochronotic Arthropathy
Forbes Tıp Dergisi, 2021 Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez +3 more
doaj +1 more source
Total knee arthroplasty in ochronosis
Arthroplasty Today, 2015 Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis).
Vaibhav G. Patel, MBBS
doaj +1 more source
Studies on the oxidative polymerization of homogentisic acid to form pyomelanin.
, 2021 The accumulation of homogentisic acid (HGA) in patients with alkaptonuria is associated with the concomitant deposition of pigments contain significant amounts of polymerised HGA (polyHGA) in the bodily tissues of the patients.
Galeb, Hanaa, Hardy, John
core +3 more sources
Oxidative DNA damage induced by homogentisic acid, a tyrosine metabolite [PDF]
, 1998 We examined the mechanism of DNA damage induced by a mutagenic tyrosine metabolite, homogentisic acid (HGA), using 32P-5′-end-labeled DNA fragments obtained from the human p53 tumor suppressor gene.
Shosuke Kawanishi +5 more
core +1 more source