Results 21 to 30 of about 2,687,981 (207)

Detection of novel visible-light region absorbance peaks in the urine after alkalization in patients with alkaptonuria. [PDF]

PLoS ONE, 2014
BACKGROUND: Alkaptonuria, caused by a deficiency of homogentisate 1,2-dioxygenase, results in the accumulation of homogentisic acid (2,5-dihydroxyphenylacetic acid, HGA) in the urine.
Yasunori Tokuhara, Kenichi Shukuya, Masami Tanaka, Mariko Mouri, Ryunosuke Ohkawa, Midori Fujishiro, Tomoo Takahashi, Shigeo Okubo, Hiromitsu Yokota, Makoto Kurano, Hitoshi Ikeda, Seiji Yamaguchi, Shinobu Inagaki, Mika Ishige-Wada, Hiromi Usui, Yutaka Yatomi, Tatsuo Shimosawa   +16 more
doaj   +1 more source

Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes.

, 2010
Alkaptonuria (AKU) is a rare genetic disease associated with the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues up to the deposition of melanin-like pigments (ochronosis).
Braconi, Daniela, Tinti, Laura, Taylor, Adam, Gallagher, J. A., Spreafico, Adriano, Bernardini, Giulia, Santucci, Annalisa, Laschi, Marcella   +7 more
core   +5 more sources

Knee osteoarthrosis secondary to ochronosis -clinical case,

Revista Brasileira de Ortopedia, 2014
Alkaptonuria is a rare metabolic disease in which a deficiency of the enzyme homogentisate dioxygenase causes an accumulation of homogentisic acid. Ochronosis consists of excessive deposition of homogentisic acid in the connective tissue and presents as ...
Andreia Maria da Silva Martins Ferreira, Filipe Lima Santos, André Miguel Castro Costa, Bruno Miguel Pereira Barbosa, Rui Miguel Reis Rocha, Joaquim Fernando Fontes Lebre   +5 more
doaj   +1 more source

Differences in the “egumi” taste of moso-bamboo shoots: research using chemical analysis and two types of taste sensors

Journal of Wood Science, 2021
We conducted our research with the aim of determining whether the “egumi” taste of moso-bamboo shoots differs depending on the production area and how the “egumi” taste of bamboo shoots from Yamagata Prefecture, which is near the northern limit of ...
Yuka Furusawa, Hitoshi Nakamura, Tatsuya Ashitani   +2 more
doaj   +1 more source

Determination of Homogentisic Acid in Urine

Clinical Chemistry, 1965
Abstract A relatively simple method for the quantitative determination of homogentisic acid in urine is presented. Homogentisic acid (2,5-dihydroxyphenylacetic acid) is oxidized by atmospheric oxygen in mild alkali to form 1,4-benzoquinone-2-acetic acid. The latter compound is then conjugated with 2,4-dinitrophenylhydrazine.
R E, Stoner, B, Blivaiss
openaire   +2 more sources

Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila

BMC Microbiology, 2017
Background Combining experimental and computational screening methods has been of keen interest in drug discovery. In the present study, we developed an efficient screening method that has been used to screen 2100 small-molecule compounds for alanine ...
Yaping Wang, Chao Yang, Wen Xue, Ting Zhang, Xipei Liu, Jiansong Ju, Baohua Zhao, Dong Liu   +7 more
doaj   +1 more source

Case Report: Ochronotic Arthropathy

Forbes Tıp Dergisi, 2021
Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez, Ece Cinar, Cihat Ozturk, Simin Hepgüler   +3 more
doaj   +1 more source

Total knee arthroplasty in ochronosis

Arthroplasty Today, 2015
Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis).
Vaibhav G. Patel, MBBS
doaj   +1 more source

Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1):an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment [PDF]

, 2016
Alkaptonuria (AKU) is a serious genetic disease characterised by premature spondyloarthropathy. Homogentisate-lowering therapy is being investigated for AKU.
Svensson, Lennart, Cox TF, Ross, G, Junestrand, Carin, Olsson, B, Hughes, Andrew T, Fitzgerald, Richard, Cox, TF, Timmis, OG, Jarvis JC, Laan D, Santucci, A, Milan, Anna M, Zatkova A, Bygott, H, Psarelli EE, Kullenberg, T, Zatkova, A, van Kan C, Fitzgerald, R, Rovensky, Jozef, Milan AM, Bygott H, Genovese F, Le Quan Sang, KH, Gallagher JA, Santucci, Annalisa, Imrich, Richard, Junestrand, C, Hall AK, van Kan, Christa, Kullenberg, Torbjörn, Ranganath, LR, Genovese, F, Gallagher, JA, Timmis, Oliver G, Psarelli, Eftychia E, Nemethova M, Christensen P, Ross, Gordon, Cox, Trevor F, Szamosi, J, Jarvis, JC, Ayoob, H, Ranganath LR, Ross G, Bygott, Helen, Le Quan Sang KH, Ranganath, Lakshminarayan R, Cronlund, Arvid, Timmis OG, Rudebeck, M, Kullenberg T, Hughes, AT, Svensson, L, Rudebeck, Mattias, Dutton JJ, Cronlund, A, Briggs MC, Imrich, R, Gallagher, James A, Olsson, Birgitta, Hall, AK, Briggs, MC, Ayoob, Hana, Psarelli, EE, Dutton, John J, Fitzgerald R, Nemethova, M, McCaffrey, J, Braconi, Daniela, McCaffrey, Judith, Christensen, P, Nemethova, Martina, Laan, Dinny, Olsson B, Sireau N, Le Quan Sang, Kim-Hanh, Cronlund A, Szamosi, Johan, Jarvis, Jonathan C, Milan, AM, Briggs, Michael C, Hughes AT, Szamosi J, Braconi, D, Genovese, Federica, Christensen, Peter, van Kan, C, Sireau, Nicolas, Rovensky J., Hall, Anthony K, Zatkova, Andrea, Laan, D, Imrich R, Sireau, N, Rudebeck M, Ayoob H, Junestrand C, Svensson L, Dutton, JJ, Rovensky, J, McCaffrey J   +102 more
core   +1 more source

Determination of Peroxidase Encapsulated in Liposomes Using Homogentisic Acid .GAMMA.-Lactone Chemiluminescence [PDF]

, 2005
Homogentisic acid γ-lactone (HAL) chemiluminescence (CL) was applied to the determination of horseradish peroxidase (HRP) encapsulated in liposomes. HRP was detected after the lysis of HRP-trapped liposomes with Triton X-100.
TANI, Hirofumi, ISHIDA, Akihiko, KIKUCHI, Nobuhito, KAMIDATE, Tamio   +3 more
core   +1 more source