Results 21 to 30 of about 3,728 (176)
Determination of Homogentisic Acid in Urine
Clinical Chemistry, 1965 Abstract A relatively simple method for the quantitative determination of homogentisic acid in urine is presented. Homogentisic acid (2,5-dihydroxyphenylacetic acid) is oxidized by atmospheric oxygen in mild alkali to form 1,4-benzoquinone-2-acetic acid. The latter compound is then conjugated with 2,4-dinitrophenylhydrazine.
R E, Stoner, B, Blivaiss
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Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila
BMC Microbiology, 2017 Background Combining experimental and computational screening methods has been of keen interest in drug discovery. In the present study, we developed an efficient screening method that has been used to screen 2100 small-molecule compounds for alanine ...
Yaping Wang +7 more
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Case Report: Ochronotic Arthropathy
Forbes Tıp Dergisi, 2021 Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez +3 more
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Total knee arthroplasty in ochronosis
Arthroplasty Today, 2015 Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis).
Vaibhav G. Patel, MBBS
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An Uncommon Clinical Presentation of a Rare Disease-Alkaptonuria: Case Report
Pakistan Armed Forces Medical Journal, 2023 Palmoplantar pigmentation is a rare clinical presentation of alkaptonuria, a rare inborn error of phenylalanine and tyrosine metabolism. Alkaptonuria occurs owing to a deficiency of an enzyme homogentisic acid oxidase inherited as an autosomal ...
Umar Abdul Ali Qureshi +1 more
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Urinary Homogentisic Acid in Alkaptonuric and Healthy Children [PDF]
Clinical Chemistry and Laboratory Medicine, 2003 To detect and follow-up the metabolic status of patients with alkaptonuria (AKU), urinary homogentisic acid (HGA) was measured by gas chromatography. These results were close to values we obtained by colorimetric method (linearity: upto 700 mg/l, detection limit: 1 mg/l, within-run imprecision (CV): 1.2% at 100 mg/l HGA, 4.9% at 10 mg/l, between-run CV:
Anna V, Oláh +5 more
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An Unusual Presentation of Ochronosis with Palmar Pigmentation [PDF]
Journal of Clinical and Diagnostic Research, 2019 Ochronosis is the deposition of homogentisic acid in connective tissues resulting in bluish black discolouration. Hereby a case of ochronosis over the palmar surface of hand in 41-year-old male patient has been reported.
Mohan Rao Nandam +4 more
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Medical Journal of Dr. D.Y. Patil University, 2015 Alkaptonuria is a rare, autosomal-recessive disorder of phenylalanine/tyrosine metabolism due to congenital deficiency of the enzyme homogentisic acid oxidase. Herein, we are reporting a classical case of alkaptonuria with extensive skin pigmentation and
Swapna S Khatu +4 more
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Knee ochronotic arthropathy and arthroscopic findings
Acta Orthopaedica et Traumatologica Turcica, 2020 Ochronotic arthropathy is a rare condition found in patients with alkaptonuria which is a hereditary metabolic disease associated with deposition of homogentisic acid derivatives in the articular cartilage, menisci, ligaments, and connective tissues due ...
Cemal Kural +4 more
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Alkaptonuria: A rare cause of recurrent severe back pain in the emergency department [PDF]
Journal of Emergency Medicine, Trauma and Acute Care, 2012 We report a 45 year-old male patient who presented to the emergency department of Hamad General Hospital with recurrent severe low back pain. Clinical examination revealed characteristic deposition of blue-brownish pigment in the sclera and ear.
MSeidahmed +2 more
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