Results 181 to 190 of about 6,837 (257)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea. [PDF]

open access: yesNat Commun
Egas RA   +5 more
europepmc   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

open access: yesInsect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour   +8 more
wiley   +1 more source

Integrated multitissue analysis reveals distinct oxidative stress responses during recovery from cold shock in the Amazonian fish Colossoma macropomum

open access: yesJournal of Fish Biology, EarlyView.
Abstract Tambaqui (Colossoma macropomum) is a tropical fish widely cultivated in South America. The increasing demand for this species has heightened interest in its cultivation in subtropical regions with greater thermal variability, where cold shock may induce oxidative stress. This study evaluated the effects of cold shock and subsequent recovery on
Naiara Melo   +7 more
wiley   +1 more source

Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis

open access: yesJournal of Integrative Plant Biology, EarlyView.
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang   +8 more
wiley   +1 more source

Coniferyl aldehyde from the phenylpropanoid pathway targets pyruvate kinase in Dactylobotrys graminicola to confer sheath rot resistance in hulless barley

open access: yesJournal of Integrative Plant Biology, EarlyView.
Hulless barley resists the newly identified sheath rot disease caused by the necrotrophic fungal pathogen Dactylobotrys graminicola by releasing coniferyl aldehyde, a natural compound that disrupts energy production in the fungus. ABSTRACT Dactylobotrys graminicola (Dgr), a necrotrophic fungal pathogen, has recently been identified as the causative ...
Haowen Zheng   +12 more
wiley   +1 more source

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