Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
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Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea. [PDF]
Egas RA +5 more
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RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour +8 more
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Infection strategies of <i>Salmonella</i>Typhimurium for gut-lumen colonization: Overcoming host defenses, exploiting host responses, and adapting to the enteric niche. [PDF]
Miki T +4 more
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Molybdenum and nitrate reductase. II. Molybdenum as a constituent of nitrate reductase.
D J, NICHOLAS, A, NASON
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Abstract Tambaqui (Colossoma macropomum) is a tropical fish widely cultivated in South America. The increasing demand for this species has heightened interest in its cultivation in subtropical regions with greater thermal variability, where cold shock may induce oxidative stress. This study evaluated the effects of cold shock and subsequent recovery on
Naiara Melo +7 more
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Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang +8 more
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Hexavalent Chromium Inhibits Nitrate-Dependent Anaerobic Methane Oxidation While Enriching Denitrifiers: Insights into Microbial Interactions for Simultaneous Methane, Nitrate, and Chromate Removal. [PDF]
Ma Y +5 more
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Hulless barley resists the newly identified sheath rot disease caused by the necrotrophic fungal pathogen Dactylobotrys graminicola by releasing coniferyl aldehyde, a natural compound that disrupts energy production in the fungus. ABSTRACT Dactylobotrys graminicola (Dgr), a necrotrophic fungal pathogen, has recently been identified as the causative ...
Haowen Zheng +12 more
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Stepwise Nitrate → Dinitrogen Transformation Mediated by a Series of Synthetic Heme/Cobalt and Heme/Copper Assemblies: Modeling Denitrification with Cytochrome <i>c</i> Oxidase Mimics. [PDF]
Shubham, Mondal P.
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