DeepNitro: Prediction of Protein Nitration and Nitrosylation Sites by Deep Learning
Genomics, Proteomics & Bioinformatics, 2018 Protein nitration and nitrosylation are essential post-translational modifications (PTMs) involved in many fundamental cellular processes. Recent studies have revealed that excessive levels of nitration and nitrosylation in some critical proteins are ...
Yubin Xie +10 more
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Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration
Redox Biology, 2018 In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide (O2â¢-) and nitric oxide (â¢NO). This process is in competition with
Silvina Bartesaghi, Rafael Radi
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Stresses, 2022 In recent years, much interest has been generated by the idea that nitrosative stress plays a role in the aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and neurological diseases.
José Manuel Pérez de la Lastra +3 more
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YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy [PDF]
Redox BiologyAims: Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is pathologically characterized by myocardial lipid deposition leading to cardiomyocyte lipotoxic injury.
Jiayin Chai +11 more
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Protein tyrosine nitration during development and abiotic stress response in plants
Frontiers in Plant Science, 2016 In recent years, the study of nitric oxide (NO) in plant systems has attracted the attention of many researchers. A growing number of investigations have shown the significance of NO as a signal molecule or as a molecule involved in the response against (
Capilla Mata Pérez +7 more
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Involvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction [PDF]
CellsEndothelial cell (EC) barrier integrity is tightly regulated by the activity of the non-muscle myosin light chain kinase (nmMLCK) under diverse pathological inflammatory conditions (pneumonia, sepsis) and exposure to mechanical stress.
Haifei Xu +9 more
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Continuous flow nitration in miniaturized devices
Beilstein Journal of Organic Chemistry, 2014 This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new
Amol A. Kulkarni
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Thermal Risk Evaluation of the Fluorobenzotriazolone Nitration Process [PDF]
MoleculesThis paper introduces the nitration process of obtaining the synthetic intermediate 1-(2-chloro-4-fluoro-5-nitrobenzene)-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one of pyraclostrobin using raw materials fluorobenzotriazolone, fuming ...
Yingxia Sheng +4 more
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Reactive Nitrogen Species and Fibrinogen: Exploring the Effects of Nitration on Blood Clots [PDF]
AntioxidantsReactive nitrogen species (RNS), particularly peroxynitrite (ONOO−), play a central role in post-translational modifications (PTMs) of proteins, including fibrinogen, a key component of the coagulation cascade.
Francesca Nencini +6 more
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Protein tyrosine nitration in higher plants grown under natural and stress conditions
Frontiers in Plant Science, 2013 Protein tyrosine nitration is a post-translational modification (PTM) mediated by reactive nitrogen species (RNS) that is linked to nitro-oxidative damages in plant cells.
Francisco J Corpas +3 more
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