YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy [PDF]
Redox BiologyAims: Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is pathologically characterized by myocardial lipid deposition leading to cardiomyocyte lipotoxic injury.
Jiayin Chai +11 more
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Involvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction [PDF]
CellsEndothelial cell (EC) barrier integrity is tightly regulated by the activity of the non-muscle myosin light chain kinase (nmMLCK) under diverse pathological inflammatory conditions (pneumonia, sepsis) and exposure to mechanical stress.
Haifei Xu +9 more
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A countercurrent microflow strategy for simultaneous high selectivity and conversion in aromatic nitration [PDF]
Nature CommunicationsAromatic nitration, a hazardously complex process, poses serious risks. A major challenge for the reaction is the trade-off effect between spatiotemporal conversion rate and selectivity, particularly the over-nitration side reactions that have plagued ...
Jing Song +8 more
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Peroxynitrite-mediated tyrosine nitration modulates β-1,3-glucanase activity and potato defense against Phytophthora infestans [PDF]
Frontiers in Plant ScienceProtein tyrosine nitration is a well-documented peroxynitrite (ONOO–)- mediated post-translational modification (PTM) in biological systems; however, its relevance in plant immune response remains poorly understood.
Karolina Izbiańska-Jankowska
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Continuous flow nitration in miniaturized devices
Beilstein Journal of Organic Chemistry, 2014 This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new
Amol Kulkarni
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Nitration in cancer signaling [PDF]
Redox BiologyOxidative stress arises from an imbalance between the production of reactive oxygen and nitrogen species (ROS and RNS, respectively) and the capacity of cellular antioxidant defenses to neutralize them.
Inge Claassen +7 more
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Thermal Risk Evaluation of the Fluorobenzotriazolone Nitration Process [PDF]
MoleculesThis paper introduces the nitration process of obtaining the synthetic intermediate 1-(2-chloro-4-fluoro-5-nitrobenzene)-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one of pyraclostrobin using raw materials fluorobenzotriazolone, fuming ...
Yingxia Sheng +4 more
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Reactive Nitrogen Species and Fibrinogen: Exploring the Effects of Nitration on Blood Clots [PDF]
AntioxidantsReactive nitrogen species (RNS), particularly peroxynitrite (ONOO−), play a central role in post-translational modifications (PTMs) of proteins, including fibrinogen, a key component of the coagulation cascade.
Francesca Nencini +6 more
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Protein Tyrosine Nitration in Plant Nitric Oxide Signaling
Frontiers in Plant Science, 2022 Nitric oxide (NO), which is ubiquitously present in living organisms, regulates many developmental and stress-activated processes in plants. Regulatory effects exerted by NO lies mostly in its chemical reactivity as a free radical.
José León
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A pilot study on nitration/dysfunction of NK1 segment of myogenic stem cell activator HGF
Biochemistry and Biophysics Reports, 2022 Protein tyrosine residue (Y) nitration, a post-translational chemical-modification mode, has been associated with changes in protein activity and function; hence the accumulation of specific nitrated proteins in tissues may be used to monitor the onset ...
Alaa Elgaabari +12 more
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