Tyrosine nitration: An emerging mechanistic landscape in neurodegeneration and cardiopulmonary disease [PDF]
Redox BiologyProtein tyrosine nitration is a post-translational modification associated with conditions of oxidative and inflammatory stress, driven by the production of reactive oxygen and nitrogen species (ROS and RNS).
Nirbachita Adrita +7 more
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Continuous Flow Nitration in Miniaturized Devices
Beilstein Journal of Organic Chemistry, 2014 This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new
Amol Arvindrao Kulkarni
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The Wheat Nitro-Proteome: Protein Nitration Profiles During Drought and Rehydration [PDF]
PlantsProtein nitration within the nitro-proteome is a dynamic component of drought and recovery responses in wheat (Triticum aestivum L.), yet its role in stress adaptation remains unclear.
Marta Gietler +2 more
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Involvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction [PDF]
CellsEndothelial cell (EC) barrier integrity is tightly regulated by the activity of the non-muscle myosin light chain kinase (nmMLCK) under diverse pathological inflammatory conditions (pneumonia, sepsis) and exposure to mechanical stress.
Haifei Xu +9 more
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A countercurrent microflow strategy for simultaneous high selectivity and conversion in aromatic nitration [PDF]
Nature CommunicationsAromatic nitration, a hazardously complex process, poses serious risks. A major challenge for the reaction is the trade-off effect between spatiotemporal conversion rate and selectivity, particularly the over-nitration side reactions that have plagued ...
Jing Song +8 more
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Peroxynitrite-mediated tyrosine nitration modulates β-1,3-glucanase activity and potato defense against Phytophthora infestans [PDF]
Frontiers in Plant ScienceProtein tyrosine nitration is a well-documented peroxynitrite (ONOO–)- mediated post-translational modification (PTM) in biological systems; however, its relevance in plant immune response remains poorly understood.
Karolina Izbiańska-Jankowska
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Nitration in cancer signaling [PDF]
Redox BiologyOxidative stress arises from an imbalance between the production of reactive oxygen and nitrogen species (ROS and RNS, respectively) and the capacity of cellular antioxidant defenses to neutralize them.
Inge Claassen +7 more
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Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide [PDF]
Scientific ReportsMyogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ...
Kahona Zushi +17 more
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YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy [PDF]
Redox BiologyAims: Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is pathologically characterized by myocardial lipid deposition leading to cardiomyocyte lipotoxic injury.
Jiayin Chai +11 more
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Fundamentals on the Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Redox Biology, 2018 In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide (O2â¢-) and nitric oxide (â¢NO). This process is in competition with
Rafael Radi, Silvina Bartesaghi
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