Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration [PDF]
Redox Biology, 2018 In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide (O2â¢-) and nitric oxide (â¢NO). This process is in competition with
Rafael Radi, Silvina Bartesaghi
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Redox Biochemistry and ChemistryProtein tyrosine nitration is a post-translational modification originating from the biological chemistry of nitric oxide. This article highlights key milestones, discusses apparent controversies and perspectives that have emerged in the last 35 years of
Harry Ischiropoulos
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Protein Tyrosine Nitration in Plant Nitric Oxide Signaling [PDF]
Frontiers in Plant Science, 2022 Nitric oxide (NO), which is ubiquitously present in living organisms, regulates many developmental and stress-activated processes in plants. Regulatory effects exerted by NO lies mostly in its chemical reactivity as a free radical.
José León
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Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 [PDF]
Frontiers in Allergy, 2023 Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases.
Janine Fröhlich-Nowoisky +4 more
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Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites [PDF]
Biochemistry and Biophysics Reports, 2022 Tetranitromethane was used to selectively modify tyrosine residues of a humanized anti-cocaine mAb (h2E2), under development for the treatment of cocaine use disorders.
Terence L. Kirley +2 more
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Peroxynitrite-mediated tyrosine nitration modulates β-1,3-glucanase activity and potato defense against Phytophthora infestans [PDF]
Frontiers in Plant ScienceProtein tyrosine nitration is a well-documented peroxynitrite (ONOO–)- mediated post-translational modification (PTM) in biological systems; however, its relevance in plant immune response remains poorly understood.
Karolina Izbiańska-Jankowska
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High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells [PDF]
Antioxidants, 2018 Diabetes and hyperglycemia are associated with increased retinal oxidative and nitrative stress and vascular cell death. Paradoxically, high glucose stimulates expression of survival and angiogenic growth factors.
Sally L. Elshaer +2 more
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Protein tyrosine nitration during development and abiotic stress response in plants [PDF]
Frontiers in Plant Science, 2016 In recent years, the study of nitric oxide (NO) in plant systems has attracted the attention of many researchers. A growing number of investigations have shown the significance of NO as a signal molecule or as a molecule involved in the response against (
Capilla Mata Pérez +7 more
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Short-Term Low Temperature Induces Nitro-Oxidative Stress that Deregulates the NADP-Malic Enzyme Function by Tyrosine Nitration in Arabidopsis thaliana [PDF]
Antioxidants, 2019 Low temperature (LT) negatively affects plant growth and development via the alteration of the metabolism of reactive oxygen and nitrogen species (ROS and RNS).
Juan C. Begara-Morales +8 more
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Design of a Protein Motif Responsive to Tyrosine Nitration and an Encoded Turn-Off Sensor of Tyrosine Nitration. [PDF]
Biochemistry, 2019 Tyrosine nitration is a protein post-translational modification that is predominantly non-enzymatic and is observed to be increased under conditions of nitrosative stress and in numerous disease states. A small protein motif (14-18 amino acids) responsive to tyrosine nitration has been developed.
Urmey AR, Zondlo NJ.
europepmc +4 more sources