Results 21 to 30 of about 207,078 (211)

Genetically Encoded Protein Tyrosine Nitration in Mammalian Cells. [PDF]

ACS Chem Biol, 2019
Tyrosine nitration has served as a major biomarker for oxidative stress and is present in high abundance in over 50 disease pathologies in humans. While data mounts on specific disease pathways from specific sites of tyrosine nitration, the role of these
Porter JJ, Jang HS, Van Fossen EM, Nguyen DP, Willi TS, Cooley RB, Mehl RA.   +6 more
europepmc   +2 more sources

Involvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction [PDF]

Cells
Endothelial cell (EC) barrier integrity is tightly regulated by the activity of the non-muscle myosin light chain kinase (nmMLCK) under diverse pathological inflammatory conditions (pneumonia, sepsis) and exposure to mechanical stress.
Haifei Xu, Jin H. Song, Joseph B. Mascarenhas, Libia A. Garcia, Susannah Patarroyo-White, Annie Hernandez, Carrie L. Kempf, Paul R. Langlais, Donna D. Zhang, Joe G. N. Garcia   +9 more
doaj   +2 more sources

Manganese superoxide dismutase (MnSOD) catalyzes NO-dependent tyrosine residue nitration [PDF]

Journal of the Serbian Chemical Society, 2005
The peroxynitrite-induced nitration of manganese superoxide dismutase (MnSOD) tyrosine residue, which causes enzyme inactivation, is well established.
SRDJAN STOJANOVIC, DRAGANA STANIC, MILAN NIKOLIC, SMILJANA RAICEVIC, MIHAJLO SPASIC, VESNA NIKETIC   +5 more
doaj   +3 more sources

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease. [PDF]

PLoS Genetics, 2016
Parkinson´s disease (PD) is characterized by the presence of proteinaceous inclusions called Lewy bodies that are mainly composed of α-synuclein (αSyn).
Alexandra Kleinknecht, Blagovesta Popova, Diana F Lázaro, Raquel Pinho, Oliver Valerius, Tiago F Outeiro, Gerhard H Braus   +6 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Protein tyrosine nitration [PDF]

Plant Signaling & Behavior, 2009
Nitric oxide metabolism in plant cells has a relative short history. Nitration is a chemical process which consists of introducing a nitro group (-NO(2)) into a chemical compound. In biological systems, this process has been found in different molecules such as proteins, lipids and nucleic acids that can affect its function.
Francisco J, Corpas, Mounira, Chaki, Marina, Leterrier, Juan B, Barroso   +3 more
openaire   +2 more sources

Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite [PDF]

Journal of Biological Chemistry, 2001
Tyrosine hydroxylase (TH) is modified by nitration after exposure of mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration with inactivation of TH activity in vitro suggests that this covalent post-translational modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S.,
B, Blanchard-Fillion, J M, Souza, T, Friel, G C, Jiang, K, Vrana, V, Sharov, L, Barrón, C, Schöneich, C, Quijano, B, Alvarez, R, Radi, S, Przedborski, G S, Fernando, J, Horwitz, H, Ischiropoulos   +14 more
openaire   +2 more sources

Inhibition of peroxidase-catalyzed protein tyrosine nitration by antithyroid drugs and their analogues [PDF]

, 2010
In this paper, we describe the effect of some commonly used thiourea-based antithyroid drugs and their analogues on the peroxidase-catalyzed nitration reactions.
Bhabak, Krishna P, Mugesh, Govindasamy
core   +2 more sources

Mechanisms of Peroxynitrite-Mediated Nitration of Tyrosine [PDF]

Chemical Research in Toxicology, 2009
The mechanisms of tyrosine nitration by peroxynitrous acid or nitrosoperoxycarbonate were investigated with the CBS-QB3 method. Either the protonation of peroxynitrite or a reaction with carbon dioxide gives a reactive peroxide intermediate. Peroxynitrous acid-mediated nitration of phenol occurs via unimolecular decomposition to give nitrogen dioxide ...
Hakan, Gunaydin, K N, Houk
openaire   +2 more sources

Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms. [PDF]

PLoS ONE, 2010
Angiotensin II (Ang II) plays a major role in the pathogenesis of insulin resistance and diabetes by inhibiting insulin's metabolic and potentiating its trophic effects.
Alfredo Csibi, David Communi, Nathalie Müller, Serge P Bottari   +3 more
doaj   +1 more source