Results 21 to 30 of about 8,951 (194)

YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy [PDF]

Redox Biology
Aims: Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is pathologically characterized by myocardial lipid deposition leading to cardiomyocyte lipotoxic injury.
Jiayin Chai, Lijie Han, Degang Mo, Yunfei Bai, Yiming Yang, Yuqing Ding, Shuai Chen, Xiangning Kong, Xinyu Zhu, Lijia Xu, Hongyan Dai, Wen Wang   +11 more
doaj   +2 more sources

Reactive Nitrogen Species and Fibrinogen: Exploring the Effects of Nitration on Blood Clots [PDF]

Antioxidants
Reactive nitrogen species (RNS), particularly peroxynitrite (ONOO−), play a central role in post-translational modifications (PTMs) of proteins, including fibrinogen, a key component of the coagulation cascade.
Francesca Nencini, Serena Borghi, Elvira Giurranna, Ilenia Barbaro, Niccolò Taddei, Claudia Fiorillo, Matteo Becatti   +6 more
doaj   +2 more sources

Manganese superoxide dismutase (MnSOD) catalyzes NO-dependent tyrosine residue nitration [PDF]

Journal of the Serbian Chemical Society, 2005
The peroxynitrite-induced nitration of manganese superoxide dismutase (MnSOD) tyrosine residue, which causes enzyme inactivation, is well established.
SRDJAN STOJANOVIC, DRAGANA STANIC, MILAN NIKOLIC, SMILJANA RAICEVIC, MIHAJLO SPASIC, VESNA NIKETIC   +5 more
doaj   +3 more sources

Copper-Catalyzed Tyrosine Nitration [PDF]

Journal of the American Chemical Society, 2011
Tyrosine nitration, often observed during neurodegenerative disorders under nitrative stress, is usually considered to be induced chemically either by nitric oxide and oxygen forming nitrogen dioxide or by the decomposition of peroxynitrite. It can also be induced enzymatically by peroxidases or superoxide dismutases in the presence of both hydrogen ...
Liang Qiao, Yu Lu, Baohong Liu, Hubert H. Girault   +3 more
openaire   +3 more sources

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease. [PDF]

PLoS Genetics, 2016
Parkinson´s disease (PD) is characterized by the presence of proteinaceous inclusions called Lewy bodies that are mainly composed of α-synuclein (αSyn).
Alexandra Kleinknecht, Blagovesta Popova, Diana F Lázaro, Raquel Pinho, Oliver Valerius, Tiago F Outeiro, Gerhard H Braus   +6 more
doaj   +1 more source

Protein tyrosine nitration [PDF]

Plant Signaling & Behavior, 2009
Nitric oxide metabolism in plant cells has a relative short history. Nitration is a chemical process which consists of introducing a nitro group (-NO(2)) into a chemical compound. In biological systems, this process has been found in different molecules such as proteins, lipids and nucleic acids that can affect its function.
Francisco J, Corpas, Mounira, Chaki, Marina, Leterrier, Juan B, Barroso   +3 more
openaire   +2 more sources

Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite [PDF]

Journal of Biological Chemistry, 2001
Tyrosine hydroxylase (TH) is modified by nitration after exposure of mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration with inactivation of TH activity in vitro suggests that this covalent post-translational modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S.,
B, Blanchard-Fillion, J M, Souza, T, Friel, G C, Jiang, K, Vrana, V, Sharov, L, Barrón, C, Schöneich, C, Quijano, B, Alvarez, R, Radi, S, Przedborski, G S, Fernando, J, Horwitz, H, Ischiropoulos   +14 more
openaire   +2 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

A pilot study on nitration/dysfunction of NK1 segment of myogenic stem cell activator HGF

Biochemistry and Biophysics Reports, 2022
Protein tyrosine residue (Y) nitration, a post-translational chemical-modification mode, has been associated with changes in protein activity and function; hence the accumulation of specific nitrated proteins in tissues may be used to monitor the onset ...
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Miyumi Seki, Sakiho Tanaka, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Judy E. Anderson, Ryuichi Tatsumi   +12 more
doaj   +1 more source

Mechanisms of Peroxynitrite-Mediated Nitration of Tyrosine [PDF]

Chemical Research in Toxicology, 2009
The mechanisms of tyrosine nitration by peroxynitrous acid or nitrosoperoxycarbonate were investigated with the CBS-QB3 method. Either the protonation of peroxynitrite or a reaction with carbon dioxide gives a reactive peroxide intermediate. Peroxynitrous acid-mediated nitration of phenol occurs via unimolecular decomposition to give nitrogen dioxide ...
Hakan, Gunaydin, K N, Houk
openaire   +2 more sources