Tyrosine nitration in prostaglandin H2 synthase [PDF]
Journal of Lipid Research, 2002 In this study, we investigated the effects of various nitrogen oxide (NOx) species on the extent of prostaglandin H2 synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells.
Ruba S. Deeb +5 more
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Nitration in cancer signaling [PDF]
Redox BiologyOxidative stress arises from an imbalance between the production of reactive oxygen and nitrogen species (ROS and RNS, respectively) and the capacity of cellular antioxidant defenses to neutralize them.
Inge Claassen +7 more
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SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin‐deficient mice [PDF]
Physiological Reports, 2019 The sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is the predominant isoform in cardiac muscles and is inhibited by phospholamban (PLN).
Jessica L. Braun +3 more
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Tyrosine nitration as mediator of cell death. [PDF]
Cell Mol Life Sci, 2014 Nitrotyrosine is used as a marker for the production of peroxynitrite and other reactive nitrogen species. For over 20 years the presence of nitrotyrosine was associated with cell death in multiple pathologies. Filling the gap between correlation and causality has proven to be a difficult task.
Franco MC, Estévez AG.
europepmc +4 more sources
Tubulin tyrosine nitration regulates microtubule organization in plant cells [PDF]
Frontiers in Plant Science, 2013 During last years, selective tyrosine nitration of plant proteins gains importance as well-recognized pathway of direct nitric oxide (NO) signal transduction.
Yaroslav B. Blume +3 more
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Protein tyrosine nitration in higher plants grown under natural and stress conditions
Frontiers in Plant Science, 2013 Protein tyrosine nitration is a post-translational modification (PTM) mediated by reactive nitrogen species (RNS) that is linked to nitro-oxidative damages in plant cells.
JOSÉ M Palma +2 more
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Tyrosine nitration of cytosolic peroxidase is probably triggered as a long distance signaling response in sunflower seedling cotyledons subjected to salt stress. [PDF]
PLoS ONE, 2018 Present work focuses on tissue and concentration-dependent effect of nitric oxide (NO) on the modulation of cytosolic peroxidase (POD; EC 1.11.1.7) activity in 2-day old etiolated sunflower (Helianthus annuus L.) seedlings.
Prachi Jain, Satish C Bhatla
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Target of tyrosine nitration in diabetic rat retina. [PDF]
Mol Cell Proteomics, 2011 Diabetic retinopathy, a retinal vascular disease, is inhibited in animals treated with aminoguanidine, an inhibitor of inducible nitric-oxide synthase. This treatment also reduces retinal protein nitration, which is greater in diabetic rat retina than nondiabetic retina.
Xianquan, Zhan +5 more
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Proteomic approaches to analyze protein tyrosine nitration. [PDF]
Antioxid Redox Signal, 2013 The conversion of protein-bound Tyr residues to 3-nitrotyrosine (3NY) can occur during nitrative stress and has been correlated to aging and many disease states. Proteomic analysis of this post-translational modification, using mass spectrometry-based techniques, is crucial for understanding its potential role in pathological and physiological ...
Feeney MB, Schöneich C.
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Involvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction [PDF]
CellsEndothelial cell (EC) barrier integrity is tightly regulated by the activity of the non-muscle myosin light chain kinase (nmMLCK) under diverse pathological inflammatory conditions (pneumonia, sepsis) and exposure to mechanical stress.
Haifei Xu +9 more
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