Results 1 to 10 of about 532 (88)

Manganese superoxide dismutase (MnSOD) catalyzes NO-dependent tyrosine residue nitration [PDF]

Journal of the Serbian Chemical Society, 2005
The peroxynitrite-induced nitration of manganese superoxide dismutase (MnSOD) tyrosine residue, which causes enzyme inactivation, is well established.
SRDJAN STOJANOVIC, DRAGANA STANIC, MILAN NIKOLIC, SMILJANA RAICEVIC, MIHAJLO SPASIC, VESNA NIKETIC   +5 more
doaj   +3 more sources

Elevated iNOS and 3′-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model

Tumour Virus Research, 2023
Kaposi's Sarcoma (KS) is a heterogenous, multifocal vascular malignancy caused by the human herpesvirus 8 (HHV8), also known as Kaposi's Sarcoma-Associated Herpesvirus (KSHV). Here, we show that KS lesions express iNOS/NOS2 broadly throughout KS lesions,
Olga Vladimirova, Samantha Soldan, Chenhe Su, Andrew Kossenkov, Owen Ngalamika, For Yue Tso, John T. West, Charles Wood, Paul M. Lieberman   +8 more
doaj   +1 more source

Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins

Frontiers in Chemistry, 2022
A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species are innocuous by-products of pathology and which are causative agents.
Elise M. Van Fossen, Sonia Grutzius, Carl E. Ruby, Dan V. Mourich, Chris Cebra, Shay Bracha, P. Andrew Karplus, Richard B. Cooley, Ryan A. Mehl   +8 more
doaj   +1 more source

Bioinformatics analysis reveals biophysical and evolutionary insights into the 3-nitrotyrosine post-translational modification in the human proteome [PDF]

Open Biology, 2013
Protein 3-nitrotyrosine is a post-translational modification that commonly arises from the nitration of tyrosine residues. This modification has been detected under a wide range of pathological conditions and has been shown to alter protein function ...
John Y. Ng, Lies Boelen, Jason W. H. Wong   +2 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

L-ergothioneine reduces nitration of lactoferrin and loss of antibacterial activity associated with nitrosative stress

Biochemistry and Biophysics Reports, 2023
Lactoferrin (LF) is a multifunctional antimicrobial, anti-inflammatory, and antioxidant protein that occurs naturally in mammals, most notably in exocrine gland tissues and fluids, such as in the eye.
Amani Y. Alhalwani, Rachel L. Davey, John E. Repine, J. Alex Huffman   +3 more
doaj   +1 more source

Nitrotyrosine level was associated with mortality in patients with acute kidney injury. [PDF]

PLoS ONE, 2013
BACKGROUND: To examine the characteristics of oxidative stress in patients with acute kidney injury (AKI) and investigate the association between plasma nitrotyrosine levels and 90-day mortality in patients with AKI.
Jing Qian, Huaizhou You, Qiuyu Zhu, Shuai Ma, Ying Zhou, Ying Zheng, Junfeng Liu, Dingwei Kuang, Yong Gu, Chuanming Hao, Feng Ding   +10 more
doaj   +1 more source

Different behavior of 3-nitrotyrosine and tyrosine toward perfluorinated reagents suitable for one-step preparation of volatile derivatives [PDF]

Journal of the Serbian Chemical Society, 2012
In view to develop a gas-chromatographic (GC) determination of the 3-nitrotyrosine (NY)/tyrosine (Y) ratio as a marker of nitro-oxidative stress, different reagents were tested with the objective of obtaining a single volatile fluorinated product for ...
Pavlović Radmila, Biondi Antonio Pier, Chiesa Maria Luca, Trutić Nataša, Abramović Mirjana, Santaniello Enzo   +5 more
doaj   +1 more source

Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?

Antioxidants, 2022
Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases (CVDs), which are the most important cause of morbidity and mortality in the population of patients living with DM.
Grzegorz K. Jakubiak, Grzegorz Cieślar, Agata Stanek   +2 more
doaj   +1 more source

In vitro production of peroxynitrite by haemocytes from marine bivalves: C-ELISA determination of 3-nitrotyrosine level in plasma proteins from Mytilus galloprovincialis and Crassostrea gigas

BMC Immunology, 2001
Background Peroxynitrite is increasingly proposed as a contributor to defence system in marine bivalve. It can be formed by combinaison of superoxide and nitric oxide, and can react with tyrosine residues of proteins giving rise to 3-nitrotyrosine ...
Romestand Bernard, Torreilles Jean
doaj   +1 more source