Results 41 to 50 of about 532 (88)

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, Volume 183, Issue 21, Page 6371-6385, November 2026.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Cellular Membrane‐Targeted Europium(III) Probe for Selective and Time‐Resolved Detection of Peroxynitrite

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Jamie Webb, Rebecca Tiffany, Karolis Norvaisa, Hennie Valkenier, Lea Miebach, Sander Bekeschus, Stephen J. Butler   +6 more
wiley   +1 more source

TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules identified by screening a compound library.

PLoS ONE
Tubulin tyrosine ligase 12 (TTLL12) is a promising target for therapeutic intervention since it has been implicated in tumour progression, the innate immune response to viral infection, ciliogenesis and abnormal cell division.
Amit Deshpande, Jan Brants, Christine Wasylyk, Onno van Hooij, Gerald W Verhaegh, Peter Maas, Jack A Schalken, Bohdan Wasylyk   +7 more
doaj   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Herbal Formula AC591 Protects Against Cisplatin‐Induced Hearing Loss by Inhibiting p53‐Mediated Ferroptosis

Smart Medicine, Volume 5, Issue 5, October 2026.
AC591 and its core active component 18β‐glycyrrhetinic acid effectively alleviate cisplatin‐induced ototoxicity by binding p53 and suppressing p53‐mediated ferroptosis, representing promising agents for preventing cisplatin‐related hearing loss. ABSTRACT Cisplatin is a widely utilized chemotherapeutic agent for the treatment of malignant cancers ...
Yunhao Wu, Yu Tao, Lin Wei, Qiuping Liu, Jiaxin Liu, Wen Jiang, Weiwei Shi, Peng Cao, Xiaolong Fu, Cheng Cheng   +9 more
wiley   +1 more source

Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood–brain barrier, and damage in the nigral dopaminergic system

Neurobiology of Disease, 2004
We have evaluated the potential neuroprotectant activity of minocycline in an animal model of Parkinson's disease induced by intranigral injection of lipopolysaccharide. Minocycline treatment was very effective in protecting number of nigral dopaminergic
Mayka Tomás-Camardiel, Inmaculada Rite, Antonio J Herrera, Rocio M de Pablos, Josefina Cano, Alberto Machado, José L Venero   +6 more
doaj   +1 more source

A Review on Cyanidin‐3‐O‐glucoside Antioxidant Activity, Food Technology Applications and Therapeutic Uses

Journal of Food Science, Volume 91, Issue 10, October 2026.
ABSTRACT Anthocyanins are plant derived biomolecules that play roles in pollination and protection against ultraviolet light (UV) radiation, as well as reactive oxygen and nitrogen species (ROS and RNS, respectively). Cyanidin 3‐O‐glucoside (C3G), a common anthocyanin in the diet, exhibits antioxidant capacity that depends on its chemical structure ...
Eiko Osawa‐Martínez, Yury Rodríguez‐Yáñez, Benito Minjarez, Salvador Mena‐Munguía, Irais Poblete‐Naredo, Adolfo Sierra‐Santoyo, Arnulfo Albores   +6 more
wiley   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, Volume 134, Issue 5, October 2026.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

Content of nitric oxide and glycative compounds in cured meat products-Negative impact upon health

BioMedicine, 2018
The content of nitric oxide (NO), 3-nitrotyrosine, advanced glycation endproducts (AGEs) and trans fatty acids (TFAs) in 16 kinds of cured meat products was examined.
Yang Ya-chen, Wang Zhi-hong, Yin Mei-chin   +2 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source