Results 51 to 60 of about 532 (88)

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

3-Nitrotyrosine activates excitatory interneurons by inhibiting GABA receptors in the rat spinal dorsal horn

PAIN Reports
. Introduction:. 3-Nitrotyrosine (3-NT) is a stable biomarker formed when reactive nitrogen species (RNS) interact with tyrosine residues. Emerging evidence suggests that RNS can amplify pain and contribute to chronic pain conditions.
Yuta Kaimochi, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Ryo Miyake, Yuta Yamamoto, Terumasa Nakatsuka, Hiroshi Yamada   +9 more
doaj   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Plasma levels of tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, and 3-nitrotyrosine in drug-resistant and drug-sensitive pulmonary tuberculosis patients, Ibadan, Nigeria

International Journal of Mycobacteriology, 2020
Background: Nigeria is one of the countries with a high burden of tuberculosis (TB) in the world. TB associated inflammation is reported to be central to progression from latent TB to active TB or drug sensitive TB (DSTB) to drug resistant TB (DRTB ...
Elizabeth Bosede Bolajoko, Olatunbosun Ganiyu Arinola, Georgina Njideka Odaibo, Mamoudou Maiga   +3 more
doaj   +1 more source

Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Occurrence of Parkinson's disease (PD) based on several neurotoxins. Advanced and comprehensive mechanisms based on Paraquat‐induced PD. Mechanism of oxidative stress, ROS and RNS formation, and death of dopaminergic neurons. The modulation of genes and proteins by paraquat leads to Parkinsonism.
Saima Riaz, Shaukat Ali, Muhammad Summer, Amina Iqbal, Rimsha Ashraf, Ramzana Bibi   +5 more
wiley   +1 more source

Proteomics quantification of protein nitration

Reviews in Analytical Chemistry, 2013
Protein tyrosine nitration is a post-translational modification (PTM) that can occur in biological systems under conditions of oxidative stress. This PTM can impact protein structure and function and has been linked to diseases such as Alzheimer’s ...
Evans Adam R., Robinson Renã A.S.
doaj   +1 more source

Neuronal Nitric Oxide Synthase Induction in the Antitumorigenic and Neurotoxic Effects of 2-Methoxyestradiol

Molecules, 2014
Objective: 2-Methoxyestradiol, one of the natural 17β-estradiol derivatives, is a novel, potent anticancer agent currently being evaluated in advanced phases of clinical trials.
Magdalena Gorska, Alicja Kuban-Jankowska, Michal Aleksander Zmijewski, Monika Gorzynik, Michal Szkatula, Michal Wozniak   +5 more
doaj   +1 more source

Serum 3-Nitrotyrosine in the Cardiovascular Disease of Patients with Systemic Lupus Erythematosus

Antioxidants
3-Nitrotyrosine (3-NT) is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It serves as an indicator of inflammation, cell damage, and nitric oxide production.
Juan C. Quevedo-Abeledo, Marta Hernández-Díaz, María García-González, Fuensanta Gómez-Bernal, Cristina Almeida-Santiago, Elena Heras-Recuero, Antonia de Vera-González, Alejandra González-Delgado, Pedro Abreu-González, Beatriz Tejera-Segura, Candelaria Martín-González, Miguel Á. González-Gay, Iván Ferraz-Amaro   +12 more
doaj   +1 more source

Otoprotective effect of MnTBAP in cisplatin-induced hearing loss.

PLoS ONE
ObjectiveCisplatin, a life-saving chemotherapeutic drug, causes ototoxicity. Although sodium thiosulfate is used to prevent ototoxicity in pediatric patients, no other intervention has been approved for clinical use against cisplatin-induced hearing loss.
Shomaila Mehmood, Pankaj Bhatia, Samson Jamesdaniel   +2 more
doaj   +1 more source

The gut microbiota-aromatic amino acid axis in cardiovascular disease: pathophysiological roles, translational biomarkers, and therapeutic targeting

Frontiers in Cardiovascular Medicine
BackgroundCardiovascular disease (CVD) remains a leading global health burden, with conventional risk factors lacking sufficient predictive power. Gut microbiota-derived aromatic amino acid (AAA) metabolites and oxidative tyrosine post-translational ...
Yurong Wu, Rui Xu
doaj   +1 more source