Results 31 to 40 of about 8,951 (194)

Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms. [PDF]

PLoS ONE, 2010
Angiotensin II (Ang II) plays a major role in the pathogenesis of insulin resistance and diabetes by inhibiting insulin's metabolic and potentiating its trophic effects.
Alfredo Csibi, David Communi, Nathalie Müller, Serge P Bottari   +3 more
doaj   +1 more source

Protein nitration: A connecting bridge between nitric oxide (NO) and plant stress

Plant Stress, 2021
Nitric oxide (•NO) is a free radical which exerts a myriad of functions in the physiology of higher plants either under physiological and environmental stress conditions.
Francisco J. Corpas, Salvador González-Gordo, José M Palma   +2 more
doaj   +1 more source

RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury

Redox Biology, 2021
Acute lung injury (ALI), a devastating illness induced by systemic inflammation e.g., sepsis or local lung inflammation e.g., COVID-19 mediated severe pneumonia, has an unacceptably high mortality and has no effective therapy.
Ting Wang, Manivannan Yegambaram, Christine Gross, Xutong Sun, Qing Lu, Hui Wang, Xiaomin Wu, Archana Kangath, Haiyang Tang, Saurabh Aggarwal, Stephen M. Black   +10 more
doaj   +1 more source

A possible link between astrocyte activation and tau nitration in Alzheimer's disease

Neurobiology of Disease, 2008
Alzheimer's disease (AD) pathology has been characterized, in part, by the self-assembly of the tau molecule into neurofibrillary tangles (NFT). While different post-translational modifications have been identified that accelerate tau aggregation ...
Juan F. Reyes, Matthew R. Reynolds, Peleg M. Horowitz, Yifan Fu, Angela L. Guillozet-Bongaarts, Robert Berry, Lester I. Binder   +6 more
doaj   +1 more source

iNitroY-Deep: Computational Identification of Nitrotyrosine Sites to Supplement Carcinogenesis Studies Using Deep Learning

IEEE Access, 2021
In biological systems, Nitration is a crucial post-translational modification which occurs on various amino acids. Nitration of Tyrosine is regarded as nitorsative stress biomarker resulting in the formation of peroxynitrite and other reactive and ...
Sheraz Naseer, Rao Faizan Ali, Suliman Mohamed Fati, Amgad Muneer   +3 more
doaj   +1 more source

Nitrogen Dioxide at Ambient Concentrations Induces Nitration and Degradation of PYR/PYL/RCAR Receptors to Stimulate Plant Growth: A Hypothetical Model

Plants, 2019
Exposing Arabidopsis thaliana (Arabidopsis) seedlings fed with soil nitrogen to 10−50 ppb nitrogen dioxide (NO2) for several weeks stimulated the uptake of major elements, photosynthesis, and cellular metabolisms to more than double the biomass of ...
Misa Takahashi, Hiromichi Morikawa
doaj   +1 more source

Regulation of Dual Activity of Ascorbate Peroxidase 1 From Arabidopsis thaliana by Conformational Changes and Posttranslational Modifications

Frontiers in Plant Science, 2021
Ascorbate peroxidase (APX) is an important reactive oxygen species (ROS)-scavenging enzyme, which catalyzes the removal of hydrogen peroxide (H2O2) to prevent oxidative damage.
Shubhpreet Kaur, Shubhpreet Kaur, Prapti Prakash, Prapti Prakash, Dong-Ho Bak, Sung Hyun Hong, Chuloh Cho, Moon-Soo Chung, Jin-Hong Kim, Jin-Hong Kim, Sungbeom Lee, Sungbeom Lee, Hyoung-Woo Bai, Hyoung-Woo Bai, Sang Yeol Lee, Byung Yeoup Chung, Seung Sik Lee, Seung Sik Lee   +17 more
doaj   +1 more source

Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation

Redox Biology
Tumors develop in an oxidative environment characterized by peroxynitrite production and downstream protein tyrosine (Y) nitration. We showed that tyrosine nitration supports schwannoma cell proliferation and regulates cell metabolism in the inheritable ...
Isabelle E. Logan, Kyle T. Nguyen, Tilottama Chatterjee, Bhagyashree Manivannan, Ngozi P. Paul, Sharon R. Kim, Evelyn M. Sixta, Lydia P. Bastian, Carrie Marean-Reardon, Matthias A. Karajannis, Cristina Fernández-Valle, Alvaro G. Estevez, Maria Clara Franco   +12 more
doaj   +1 more source

RNA and mRNA Nitration as a Novel Metabolic Link in Potato Immune Response to Phytophthora infestans

Frontiers in Plant Science, 2018
Peroxynitrite (ONOO-) exhibits a well-documented nitration activity in relation to proteins and lipids; however, the interaction of ONOO- with nucleic acids remains unknown in plants.
Karolina Izbiańska, Jolanta Floryszak-Wieczorek, Joanna Gajewska, Barbara Meller, Daniel Kuźnicki, Magdalena Arasimowicz-Jelonek   +5 more
doaj   +1 more source

Proteolytic Degradation of Tyrosine Nitrated Proteins

Archives of Biochemistry and Biophysics, 2000
Tyrosine nitration is a covalent posttranslational protein modification that has been detected under several pathological conditions. This study reports that nitrated proteins are degraded by chymotrypsin and that protein nitration enhances susceptibility to degradation by the proteasome.
J M, Souza, I, Choi, Q, Chen, M, Weisse, E, Daikhin, M, Yudkoff, M, Obin, J, Ara, J, Horwitz, H, Ischiropoulos   +9 more
openaire   +2 more sources