Which are the options and dosages for clobazam shortages on epilepsy treatment? Review of literature and survey of specialists [PDF]
Clobazam (CLB) has been an established treatment for epilepsy since the 1970s, with a broad spectrum. It is frequently used as add on therapy for refractory patients. Furthermore, it is different from classic benzodiazepines (BZD) for containing nitrogen
Lécio Figueira Pinto +2 more
doaj +2 more sources
SPECTROPHOTOMETRIC DETERMINATION OF NITRAZEPAM IN TABLETS [PDF]
A sensitive spectrophotometric method is reported for the determination of nitrazepam either pure or in tablets. The method is based on the reduction of nitrazepam with zinc dust and calcium chloride followed by reacting the reduced compound with ...
Salwa El-Shabouri
doaj +3 more sources
Adverse events of pharmacological interventions for insomnia disorder in adults: a systematic review and network meta-analysis [PDF]
BackgroundThe clinical decision-making to insomnia drugs should comprehensively weight its risks.ObjectiveTo perform a systematic review and network meta-analysis of randomized controlled trials to compare the AEs associated with different insomnia drugs
Changhong Lu +5 more
doaj +2 more sources
Consumption patterns and factors associated with inappropriate prescribing of benzodiazepines in Primary Health Care settings. [PDF]
BackgroundBenzodiazepines are frequently prescribed to treat anxiety and insomnia, but long-term use has been associated with the development of dependence, tolerance, and cognitive decline, especially among older adults.
Maria Olívia Barboza Zanetti +5 more
doaj +2 more sources
Agitated Depression Associated With Flurazepam Discontinuation [PDF]
Agitated depression, also known as melancholia agitata, is a variant of depression characterized by severe symptoms of psychomotor agitation, inner unrest, anxiety, restlessness, prominent vegetative symptoms, and a high risk of suicide.
Mohamed Salih +6 more
doaj +2 more sources
Indirect Spectrophotometric Determination of Nitrazepam by Charge Transfer Complex Formation Reaction Using p-Bromanil as π-Acceptor [PDF]
A sensitive spectrophotometric method for the determination of nitrazepam in pure as well as in dosage form is described. The method is based on the reaction of reduced nitrazepam (RNZ) with p-bromanil in the presence of borate buffer solution of pH9 to ...
Subhi M. Al-Mtaiwti
doaj +1 more source
A STUDY ON THE SOLUBILITY AND STABILITY OF DIAZEPAM AND NITRAZEPAM IN BUFFERED MIXTURES [PDF]
Diazepam and Nitrazepam were solubilized by a series of commercial nonionic surfactant solutions buffered to pH 4, 6 and 7 at 35°C. These nonionic surfactants include Eumulgin C 1000 and C 1500 and Brij 35 and 58. It was found that the surfactant and the
A. Abdel-Zaher, M. Mesiha, A. Aboutaleb
doaj +1 more source
Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets Using Flow Injection Analysis [PDF]
Nitrazepam (NZP) was determined spectrophotometrically in the pure form and in the pharmaceutical tablets using flow injection analysis (FIA). The method was based on oxidative coupling organic reaction of reduced NZP with promethazine hydrochloride in ...
Raghad Sinan Abdulsattar
doaj +1 more source
Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol [PDF]
A simple and sensitive spectrophotometric method was developed for the determination of nitrazepam (NZP) in pharmaceutical tablets. The method was based on oxidative coupling organic reaction of reduced NZP with pyrocatechol in the presence of ferric ...
Raghad.S Abdul Sattar +1 more
doaj +1 more source
The objectives of this research were to prepare and characterize inclusion complexes of Nitrazepam with Hydroxypropyl-β-cyclodextrin (HPβCD) and Sulfobutyl ether β-cyclodextrin (SBEβCD) to study the effect of complexation on the dissolution rate of ...
J S Patel, R P Patel
doaj +1 more source

