Comparative effects of hypnotic agents on sleep architecture and respiratory outcomes in obstructive sleep apnea: A systematic review and network meta-analysis. [PDF]
Aim This network meta‐analysis of randomized controlled trials (RCTs) aimed to investigate which hypnotics are associated with the most favorable sleep architecture and respiratory outcomes in adults with obstructive sleep apnea. Methods Primary outcomes included total sleep time (TST) and apnea–hypopnea index (AHI) during TST.
Kishi T +6 more
europepmc +2 more sources
Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia. [PDF]
In a Japanese patient with schizophrenia, the effects of repeated smoking and quitting cigarettes on plasma concentrations of clozapine (CLZ) and its major metabolites, N‐desmethyl clozapine (NCLZ) and N‐oxide clozapine (OCLZ), were shown to be reproducible. ABSTRACT Clozapine (CLZ) is used for treatment‐resistant schizophrenia.
Ikawa K +3 more
europepmc +2 more sources
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open-label prospective study. [PDF]
Abstract Objective CDKL5 deficiency disorder (CDD) is an early‐onset developmental and epileptic encephalopathy characterized by frequent drug‐resistant seizures, cerebral visual impairment, motor dysfunction, and sleep and gastrointestinal disturbances.
Perulli M +12 more
europepmc +2 more sources
Effects of Opioids, Benzodiazepines, Gabapentinoids, and Antidepressants on Fracture Risk in Alcohol-Related Cirrhosis. [PDF]
ABSTRACT Background Patients with alcohol‐related liver cirrhosis (ALD cirrhosis) have an increased risk of falls and fractures. Opioids, benzodiazepines, gabapentinoids, and antidepressants are known to increase fall risk. Aims We aimed to determine the effects of opioids, benzodiazepines, gabapentinoids, and antidepressants on fracture risk in ALD ...
Kraglund F +4 more
europepmc +2 more sources
Postictal psychosis concealed during long-term video-electroencephalographic monitoring and unmasked after discharge: A case report. [PDF]
Abstract Background Postictal psychosis (PIP) is a serious complication that can follow seizure clusters, including those provoked during long‐term video‐electroencephalographic monitoring (LTVEM). Early detection and appropriate treatment of PIP are crucial to implement LTVEM safely.
Fujiwara S +8 more
europepmc +2 more sources
Spectrophotometric Determination Of Nitrazepam And Dapson Using Vanillin Reagent in Pharmaceutical Preparations [PDF]
A simple, sensitive and selective spectrophotometric method is described for the determination of dapson and nitrazepam in bulk drug and in dosage forms using vanillin as the chromogenic agent.
Maha Al-Obaidi +2 more
doaj +1 more source
Utilizing the batch Diazotization coupling reaction and the cloud point extraction kinetic spectrophotometric method, trace and Ultra trace amounts from reducing Nitrazepam and Clonazepam were evaluated by way of using 2,5-dimethoxyaniline as a new ...
Mahdi Muna Iskandar +1 more
doaj +1 more source
Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system. [PDF]
The tail suspension test (TST) is widely recognized as a useful experimental paradigm for assessing antidepressant activity and depression-like behavior.
Saki Imai +6 more
doaj +1 more source
Foi comparada a potência anticonvulsivamente do nitrazepam, do diazepam e da trimetadiona em 5 pacientes com ausências mioclônicas. Os doentes receberam, além das medicações anticonculsivantes, um placebo.
Michel Pierre Lison
doaj +1 more source
SUMMARY The sedative effects of nitrazepam in a dose of 5 mg and 10 mg have been compared with Mandrax, a combination of methaqualone 250 mg with diphenhydramine 25 mg. Studies were carried out in gynaecological patients undergoing minor surgical operations using the scoring system previously described.
W, Norris, A B, Telfer
openaire +2 more sources

