Results 91 to 100 of about 347,268 (305)

Flavonoids and nitric oxide synthase.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2002
Induction of NOS-2 in macrophages and smooth muscles within vascular wall with concomittant suppression of endothelial NOS-3 activity is considered to be a hallmark of vascular inflammation that triggers atherogenesis. Accordingly, drugs designed to reverse these changes should not only support vaning function of NOS-3 but also suppress proinflammatory
Olszanecki, Rafał, Gębska, Anna, Kozlovski, V. I., Gryglewski, Ryszard   +3 more
openaire   +2 more sources

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Investigations into potential extrasynaptic communication between the dopaminergic and nitrergic systems

Frontiers in Physiology, 2012
Nitric oxide is unconstrained by cell membranes and can therefore act along a broad distance as a volume transmitter. Spillover of nitric oxide between neurons may have a major impact on central nervous system diseases and particularly on ...
Miso eMitkovski, Fernando Eduardo Padovan-Neto, Rita eRaisman-Vozari, Rita eRaisman-Vozari, Laure eGinestet, Laure eGinestet, Celia eDa-Silva, Elaine eDel Bel, Elaine eDel Bel   +8 more
doaj   +1 more source

Further observations on the role of nitric oxide in the feline lateral geniculate nucleus [PDF]

, 1996
[Abstract] We have examined the responses of a population of 77 cells in the dorsal lateral geniculate nucleus (dLGN) of the anaesthetized, paralysed cat.
Bickford, Black, Bohme, Bredt, Bult, Cleland, Cudeiro, Cudeiro, Dawson, Dawson, Derrington, Desai, Do, Eccles, Enroth-Cugell, Eysel, Funke, Garthwaite, Garthwaite, Garthwaite, Haley, Hartveit, Heggelund, Ito, Izumi, Kemp, Kwon, Lei, Lipton, Lipton, Lo, Lonart, Lorrain, Lundberg, Manzoni, Mayer, McCormick, McCormick, McCormick, Moncada, Montague, Murphy, Nowak, O'Dell, Pape, Pape, Scharfman, Schuman, Schuman, Shibuki, Sillito, Sillito, Sillito, Sillito, Sillito, Sillito, Singer, Snyder, Steriade, Vidyasagar, Wood   +60 more
core   +2 more sources

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

Clinics, 2013
OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene.
Ismail Sari, Yusuf Ziya Igci, Gercek Can, Ali Taylan, Dilek Solmaz, Bulent Gogebakan, Servet Akar, Zeynep Eslik, Giray Bozkaya, Nurullah Akkoc   +9 more
doaj  

Blocked dihydropteridines as nitric oxide synthase activators [PDF]

, 2010
It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon, Gazur, Ben, Gibson, C.L., McInnes, Craig R., Morthala, Raghavendar R., Suckling, C.J.   +5 more
core  

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Neuronal and inducible nitric oxide synthase upregulation in the rat medial prefrontal cortex following acute restraint stress: A dataset

Data in Brief, 2016
This data article provides additional evidence on gene expression changes in the neuronal and inducible isoforms of nitric oxide synthase in the medial prefrontal cortex following acute stress.
Jereme G. Spiers, Hsiao-Jou Cortina Chen, Johnny K. Lee, Conrad Sernia, Nickolas A. Lavidis   +4 more
doaj   +1 more source

Nitric oxide production by the human intestinal microbiota by dissimilatory nitrate reduction to ammonium [PDF]

, 2009
The free radical nitric oxide (NO) is an important signaling molecule in the gastrointestinal tract. Besides eukaryotic cells, gut microorganisms are also capable of producing NO. However, the exact mechanism of NO production by the gut microorganisms is
Vermeiren, Joan, Van de Wiele, Tom, Verstraete, Willy, Boeckx, Pascal, Boon, Nico   +4 more
core   +2 more sources