Results 11 to 20 of about 646,019 (403)

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. [PDF]

PLoS ONE, 2014
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors.
Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon   +13 more
doaj   +1 more source

Inhibition of NOS- like activity in maize alters the expression of genes involved in H2O2 scavenging and glycine betaine biosynthesis [PDF]

, 2018
Nitric oxide synthase-like activity contributes to the production of nitric oxide in plants, which controls plant responses to stress. This study investigates if changes in ascorbate peroxidase enzymatic activity and glycine betaine content in response
A Deisseroth, A Sakamoto, A Uchida, A Untergasser, C Garcia-Mata, C Lindermayr, D Clarke, D Procházková, D Rhodes, D Wendehenne, E Baudouin, EA Weretilnyk, G Perrière, HI Aebi, II Ozyigit, J Leach, JC Begara-Morales, K Yamane, KF McCue, KJL Livak, L Zhang, LA Rio Del, M Ashraf, M Cueto, M Delldonne, M Ishitani, M Yu, MA Larkin, MG Zhao, MH Siddiqui, MV Beligni, N Ludidi, RD Allen, S Ullah, SA Anjum, SAH Mackerness, SJ Neill, T Nakamura, TE Mishina, V Velikova, W Woodbury, Y Guo, Y Zhang, YJ Liu, YY Leshem   +44 more
core   +2 more sources

In vitro and in vivo TNFa synthesis modulation by methylguanidine, an uremic catabolyte [PDF]

, 1999
Original article can be found at: http://www.sciencedirect.com/science/journal/00243205 Copyright Elsevier Inc.We have investigated whether methylguanidine (MG), an uremic toxin, modulates the expression of the inducible nitric oxide synthase (iNOS) and ...
Aucella, Berczi, Deakin, Deenitchina, Deschamps-Latscha, Drapier, Garcia-Valdecasas, Garreld, Girndt, Halwachs, Jones, Kawano, Kelly, Mendes-Ribeiro, Meur, Moncada, Orita, Ruetten, Shurtz-Swirski, Sorrentino, Sorrentino, Yokozawa   +21 more
core   +1 more source

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

Frontiers in Immunology, 2014
Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses.
Meera Rath, I. Müller, P. Kropf, E. Closs, M. Munder   +4 more
semanticscholar   +1 more source

ACTIVITY MODULATION OF VARIOUS NITRIC OXIDE SYNTASES AS AN APPROACH TO ENDOTHELIAL DYSFUNCTION THERAPY

Фармация и фармакология (Пятигорск), 2022
Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted the attention of researchers at the end of the 19th century.
D. V. Kurkin, E. E. Abrosimova, D. A. Bakulin, N. S. Kovalev, M. A. Dubrovina, A. V. Borisov, A. V. Strygin, E. I. Morkovin, I. N. Tyurenkov   +8 more
doaj   +1 more source

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

Nitric oxide and nitric oxide synthase in Huntington's disease [PDF]

Journal of Neuroscience Research, 2001
AbstractNitric oxide (NO) is a biologically active inorganic molecule produced when the semiessential amino acid l‐arginine is converted to l‐citrulline and NO via the enzyme nitric oxide synthase (NOS). NO is known to be involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function ...
openaire   +2 more sources

Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy

Cardiovascular Ultrasound, 2006
Background Endothelial nitric oxide synthase produces nitric oxide which is involved in many physiologic regulatory functions. Variable number of tandem repeats in intron 4 of endothelial nitric oxide synthase gene are reported to be associated with ...
Arslan Erol, Barcin Cem, Sezer Murat, Ozbek Ugur, Ekmekci C Gokhan, Olcay Ayhan, Boztosun Bilal, Nisanci Yilmaz   +7 more
doaj   +1 more source

Nitric oxide synthases in mammals [PDF]

Biochemical Journal, 1994
Nitric oxide is an inorganic free radical gas, of formula *N=O (abbreviated as NO). The discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L-arginine as a transcellular signal [1-4] was initially received by most biologists with considerable scepticism.
R G, Knowles, S, Moncada
openaire   +2 more sources

Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase

BMC Gastroenterology, 2002
Background Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. Methods Wistar
Williamson Robin CN, Habib Nagy A, Virlos Ioannis T, Serracino-Inglott Ferdinand, Mathie Robert T   +4 more
doaj   +1 more source