Results 31 to 40 of about 347,268 (305)

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

Feedback inhibition of nitric oxide synthase activity by nitric oxide [PDF]

British Journal of Pharmacology, 1993
1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2.
J, Assreuy, F Q, Cunha, F Y, Liew, S, Moncada   +3 more
openaire   +2 more sources

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +5 more sources

Male gender predisposes to development of endotoxic shock in the rat [PDF]

, 2000
Objective: After intravenous (i.v.) injection of lipopolysaccharide (LPS) macrophages release nitric oxide (NO) due to the expression of the inducible NO synthase (iNOS).
Baylis, C., Hamar, Péter, Harvey, J., Heemann, Uwe, Kriston, Tünde, Losonczy, György, Müller, Veronika, Szabó, Attila József   +7 more
core   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

Nitric Oxide Synthase and Oxidative Stress: Regulation of Nitric Oxide Synthase

, 2012
IntroductionIl a été constaté que l'oxyde nitrique joue un rôle important en tant que molécule signal dans de nombreuses parties de l'organisme ainsi qu'en tant que molécule effectrice cytotoxique de la réponse immunitaire non spécifique.L' oxyde nitrique est une fonction très importante à la fois chez les helminthes et les hôtes mammifères.L' oxyde ...
Ehab M. M. Ali, M. Soha, Monwar Tarek
openaire   +2 more sources

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Postsynaptic α1-Adrenergic vasoconstriction is impaired in young patients with vasovagal syncope and is corrected by nitric oxide synthase inhibition [PDF]

, 2016
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope (VVS).
Medow, MS, Merchant, S, Stewart, JM, Suggs, M, Sutton, R, Terilli, C, Visintainer, P   +6 more
core   +1 more source

Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS.

PLoS ONE, 2014
BackgroundFractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain.ObjectiveTo investigate whether fractional exhaled nitric oxide is
Abraham B Roos, Michiko Mori, Reidar Grönneberg, Christina Österlund, Hans-Erik Claesson, Jan Wahlström, Johan Grunewald, Anders Eklund, Jonas S Erjefält, Jon O Lundberg, Magnus Nord   +10 more
doaj   +1 more source

Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review

Antioxidants, 2023
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely ...
Gabriele Serreli, Monica Deiana
doaj   +1 more source