Results 31 to 40 of about 508,056 (310)
Molecular Pain, 2018 Elevated N -methyl-D-aspartate receptor activity contributes to central sensitization. Our laboratories and others recently reported that disrupting protein–protein interactions downstream of N -methyl-D-aspartate receptors suppresses pain. Specifically,
Wan-Hung Lee +6 more
doaj +1 more source
Molecular Pain, 2018 Objective To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI) rats, and to analyze the influence of HBO on the expression of neuronal nitric oxide synthase and inducible nitric oxide synthase ...
Yuanyuan Ding +6 more
doaj +1 more source
Study of the nitric oxide system in the rat cerebellum during aging
BMC Neuroscience, 2010 Background The cerebellum is the neural structure with the highest levels of nitric oxide, a neurotransmitter that has been proposed to play a key role in the brain aging, although knowledge concerning its contribution to cerebellar senescence is still ...
Martinez-Lara Esther +9 more
doaj +1 more source
Feedback inhibition of nitric oxide synthase activity by nitric oxide [PDF]
British Journal of Pharmacology, 1993 1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2.
J, Assreuy +3 more
openaire +2 more sources
Inducible nitric oxide synthase: Good or bad?
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017 Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO.
Maggie Lind +6 more
semanticscholar +1 more source
Nitric Oxide Synthase and Oxidative Stress: Regulation of Nitric Oxide Synthase
, 2012 IntroductionIl a été constaté que l'oxyde nitrique joue un rôle important en tant que molécule signal dans de nombreuses parties de l'organisme ainsi qu'en tant que molécule effectrice cytotoxique de la réponse immunitaire non spécifique.L' oxyde nitrique est une fonction très importante à la fois chez les helminthes et les hôtes mammifères.L' oxyde ...
Ehab M. M. Ali, M. Soha, Monwar Tarek
openaire +2 more sources
Role of Asymmetric Dimethylarginine in Psychiatric Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2014 Asymmetric dimethylarginine has been a post-translational modified form of the aminoasid arginine. Being a competitive inhibitor of nitric oxide synthase enzyme, makes asymmetric dimethylarginine important.
Selma Bozkurt Zincir, Serkan Zincir
doaj +1 more source
Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS.
PLoS ONE, 2014 BackgroundFractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain.ObjectiveTo investigate whether fractional exhaled nitric oxide is
Abraham B Roos +10 more
doaj +1 more source
Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review
Antioxidants, 2023 Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely ...
Gabriele Serreli, Monica Deiana
doaj +1 more source
Neuronal Nitric Oxide Synthase
, 2017 Nitric oxide synthase (NOS), a flavo‐hemoprotein, regulates nitric oxide (NO) synthesis that has dual biological activities: as an important signalling molecule in vasodilatation and neurotransmission at low concentrations and at higher concentrations as
Kourosh Masoumeh Arami +2 more
semanticscholar +1 more source