Results 11 to 20 of about 181,047 (262)

ACTIVITY MODULATION OF VARIOUS NITRIC OXIDE SYNTASES AS AN APPROACH TO ENDOTHELIAL DYSFUNCTION THERAPY

Фармация и фармакология (Пятигорск), 2022
Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted the attention of researchers at the end of the 19th century.
D. V. Kurkin, E. E. Abrosimova, D. A. Bakulin, N. S. Kovalev, M. A. Dubrovina, A. V. Borisov, A. V. Strygin, E. I. Morkovin, I. N. Tyurenkov   +8 more
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Nitric oxide synthases in mammals [PDF]

Biochemical Journal, 1994
Nitric oxide is an inorganic free radical gas, of formula *N=O (abbreviated as NO). The discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L-arginine as a transcellular signal [1-4] was initially received by most biologists with considerable scepticism.
R G, Knowles, S, Moncada
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Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase

BMC Gastroenterology, 2002
Background Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. Methods Wistar
Williamson Robin CN, Habib Nagy A, Virlos Ioannis T, Serracino-Inglott Ferdinand, Mathie Robert T   +4 more
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The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis

Toxins, 2013
The aim of the study was to verify the hypothesis that intoxication with low doses of mycotoxins leads to changes in the mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes in tissues of the gastrointestinal tract and the ...
Magdalena Gajęcka, Ewa Stopa, Michał Tarasiuk, Łukasz Zielonka, Maciej Gajęcki   +4 more
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Effects of Chitosan on the Secretion of Cytokines and Expression of Inducible Nitric Oxide Synthase mRNA in Peritoneal Macrophages of Broiler Chicken

Brazilian Archives of Biology and Technology, 2014
An in vitro experiment was conducted to study the effects of chitosan on the secretion of cytokines and expression of inducible nitric oxide synthase mRNA in peritoneal macrophages of broiler chicken.
Huiying Li, Binlin Shi, Sumei Yan, Tianzhang Zhao, Junliang Li, Xiaoyu Guo   +5 more
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ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability

Molecular Pain, 2018
Elevated N -methyl-D-aspartate receptor activity contributes to central sensitization. Our laboratories and others recently reported that disrupting protein–protein interactions downstream of N -methyl-D-aspartate receptors suppresses pain. Specifically,
Wan-Hung Lee, Lawrence M Carey, Li-Li Li, Zhili Xu, Yvonne Y Lai, Michael J Courtney, Andrea G Hohmann   +6 more
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The analgesic effect of early hyperbaric oxygen treatment in chronic constriction injury rats and its influence on nNOS and iNOS expression and inflammatory factor production

Molecular Pain, 2018
Objective To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI) rats, and to analyze the influence of HBO on the expression of neuronal nitric oxide synthase and inducible nitric oxide synthase ...
Yuanyuan Ding, Peng Yao, Tao Hong, Hongxi Li, Yongqiang Zhu, Zhenkai Han, Guangyu Zhou   +6 more
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Study of the nitric oxide system in the rat cerebellum during aging

BMC Neuroscience, 2010
Background The cerebellum is the neural structure with the highest levels of nitric oxide, a neurotransmitter that has been proposed to play a key role in the brain aging, although knowledge concerning its contribution to cerebellar senescence is still ...
Martinez-Lara Esther, Rus Alma, Jimenez Ana, Hernandez Raquel, Del Moral Maria L, Castro Lourdes, Molina Francisco J, Blanco Santos, Siles Eva, Peinado Maria A   +9 more
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Feedback inhibition of nitric oxide synthase activity by nitric oxide [PDF]

British Journal of Pharmacology, 1993
1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2.
J, Assreuy, F Q, Cunha, F Y, Liew, S, Moncada   +3 more
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Nitric Oxide Synthase and Oxidative Stress: Regulation of Nitric Oxide Synthase

, 2012
IntroductionIl a été constaté que l'oxyde nitrique joue un rôle important en tant que molécule signal dans de nombreuses parties de l'organisme ainsi qu'en tant que molécule effectrice cytotoxique de la réponse immunitaire non spécifique.L' oxyde nitrique est une fonction très importante à la fois chez les helminthes et les hôtes mammifères.L' oxyde ...
Ehab M. M. Ali, M. Soha, Monwar Tarek
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