Results 11 to 20 of about 508,056 (310)

Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis [PDF]

International Dental Journal
: Objective: While diabetes is known to impair dentin regenerative capacity, the specific role of endothelial nitric oxide synthase (eNOS) is poorly defined. This study aimed to elucidate how eNOS regulates the osteo/odontogenic differentiation of human
Xuanhe Feng, Liang Hu, Chen Zhang, Wanzhen Lei, Bowen Zhou, Dengsheng Xia, Zhaochen Shan, Luyuan Jin   +7 more
doaj   +2 more sources

Nitric Oxide synthases and atrial fibrillation [PDF]

Frontiers in Physiology, 2012
Oxidative stress has been implicated in the pathogenesis of atrial fibrillation. There are multiple systems in the myocardium which contribute to redox homeostasis, and loss of homeostasis can result in oxidative stress.
Ingrid M Bonilla, Ingrid M Bonilla, Arun eSridhar, Sandor eGyorke, Sandor eGyorke, Arturo J Cardounel, Arturo J Cardounel, Cynthia Ann Carnes, Cynthia Ann Carnes   +8 more
doaj   +3 more sources

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

Redox Biology, 2021
Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset gestational hypertension with (or without) proteinuria or end-organ failure, exclusively observed in humans. It is a leading cause of maternal morbidity affecting 3–7% of
P. Guerby, Oriane Tasta, A. Swiader, F. Pont, E. Bujold, O. Parant, C. Vayssière, R. Salvayre, A. Nègre-Salvayre   +8 more
semanticscholar   +1 more source

L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells

Pulmonary Circulation, 2021
The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass, Yongmei Zhang, Mark R. Kaplowitz, Candice D. Fike   +3 more
doaj   +1 more source

Nitric oxide in gingival crevicular fluid and nitric oxide synthase expression in the gingiva of patients with sickle cell disease

Turkish Journal of Hematology, 2011
OBJECTIVE: This study aimed to biochemically measure the production of nitric oxide in gingival crevicular fluid and immunohistochemically measure the expression of inducible nitric oxide synthase in the gingiva of patients with sickle cell disease ...
Esra Güzeldemir, Hilal Uslu Toygar, Nebil Bal, Ruksan Anarat, Can Boğa   +4 more
doaj   +3 more sources

Tetrahydrobiopterin in nitric oxide synthase [PDF]

IUBMB Life, 2013
AbstractSummary: Nitric oxide synthase (NOS) is a critical enzyme for the production of the messenger molecule nitric oxide (NO) from L‐arginine. NOS enzymes require tetrahydrobiopterin as a cofactor for NO synthesis. Besides being one of the few enzymes to use this cofactor, the role of tetrahydrobiopterin in NOS catalytic mechanism is different from ...
Jesús, Tejero, Dennis, Stuehr
openaire   +2 more sources

Zinc-fortification restores gut nitric oxide without expression of inducible nitric oxide synthase gene in enterotoxigenic E. coli-induced diarrhea in zinc-deficient rats

Scientific African, 2021
Nitric oxide maintains the integrity of the gastric epithelium and is also elevated in diarrheal disease condition. Nitric oxide synthase isoforms (NOS) are responsible for production of nitric oxide (NO) in physiological and pathophysiological ...
Ebuka E. David, Muhammad A. Yameen, Ikechuku O. Igwenyi, Chidinma N. David   +3 more
doaj   +1 more source

Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy

Neural Regeneration Research, 2023
Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity, which triggers cell death in various neuropathological diseases, including epilepsy.
Xiao-Xue Xu, Rui-Xue Shi, Yu Fu, Jia-Lu Wang, Xin Tong, Shi-Qi Zhang, Na Wang, Mei-Xuan Li, Yu Tong, Wei Wang, Miao He, Bing-Yang Liu, Gui-Lan Chen, Feng Guo   +13 more
doaj   +1 more source

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. [PDF]

PLoS ONE, 2014
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors.
Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon   +13 more
doaj   +1 more source

Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition

Medicinal research reviews (Print), 2019
A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l‐arginine.
Maris A. Cinelli, H. Do, Galen P. Miley, R. Silverman   +3 more
semanticscholar   +1 more source