Results 1 to 10 of about 1,819 (263)

Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells. [PDF]

PLoS ONE, 2016
Transforming growth factor-β (TGF-β), via its receptors, induces epithelial-mesenchymal transition (EMT) and plays an important role in the development of renal tubulointersitial fibrosis.
Hui-Lin Guo, Xiao-Hui Liao, Qi Liu, Ling Zhang   +3 more
doaj   +1 more source

Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II

Behavioral and Brain Functions, 2008
We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle
Guarda Ismael FMS, Saad Wilson A, Camargo Luiz AA, Santos Talmir AFB   +3 more
doaj   +1 more source

Nitric Oxide Differentially Regulates Induction of Type II Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells Versus Macrophages [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract —We studied effects of nitric oxide (NO) released by different NO donors on induction of inducible NO synthase (iNOS) in rat aortic smooth muscle cells (RASMC) and rat macrophage cell line NR8383. iNOS protein expression induced by a CM (interleukin-1β 250 U/mL, interferon-γ 150 U/mL, and tumor necrosis factor-α 150 U ...
H, Zhang, C, Snead, J D, Catravas
openaire   +2 more sources

AT1 Receptor Mediated Hypertensive Response to Ang II in the Nucleus Tractus Solitarii of Normotensive Rats Involves NO Dependent Local GABA Release

Frontiers in Pharmacology, 2019
AimIt is well-established that angiotensin II exerts a dampening effect on the baroreflex within the nucleus tractus solitarii (NTS), the principal brainstem site for termination of baroreceptor afferents and which is densely populated with gamma ...
Laura Légat, Laura Légat, Laura Légat, Ilse Smolders, Alain G. Dupont, Alain G. Dupont, Alain G. Dupont   +6 more
doaj   +1 more source

Effect of Icariside II and Metformin on Penile Erectile Function, Histological Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction

Sexual Medicine, 2020
Introduction: Type 2 diabetes mellitus erectile dysfunction (T2DMED) is one of the common complications of type 2 diabetes mellitus (T2DM). Icariside II (ICA II), a flavonoid derived from Epimedium, has been shown to improve erectile function in T2DMED ...
Jian Zhang, MD, Shuang Li, BS, Shiqing Zhang, MS, Yonghui Wang, BS, Shipeng Jin, BS, Chunli Zhao, MS, Wenzeng Yang, MD, Yuexin Liu, MS, Guangqi Kong, MS   +8 more
doaj   +1 more source

Effects of Cinnamomum cassia extract on oxidative stress, immunreactivity of iNOS and impaired thoracic aortic reactivity induced by type II diabetes in rats

Brazilian Journal of Pharmaceutical Sciences, 2018
Type II diabetes is known to cause neuropathy, nephropathy and retinopathy. However, cardiovascular disorders associated with diabetes have been ignored.
Gözde Atila Uslu, Volkan Gelen, Hamit Uslu, Hasan Özen   +3 more
doaj   +1 more source

Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes [PDF]

Journal of Biological Chemistry, 1996
Incubation of primary cultures of rat hepatocytes with lipopolysaccharide (LPS), S-[2,3-bis(palmitoyloxy)-(2-R,S)-propyl]-N-palmitoyl-(R)-Cys-Ser-Lys4 (TPP), a synthetic lipopeptide present in bacterial cell wall lipoproteins, or with phorbol 12,13-dibutyrate (PDBu) induced an increase in nitric oxide synthesis through the expression of type II nitric ...
Díaz-Guerra, María José, Velasco, Marta, Martín-Sanz, Paloma, Boscá, Lisardo   +3 more
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Increased hepatic expression of nitric oxide synthase type II in cirrhotic rats

World Journal of Gastroenterology, 2004
To determine the role and effect of nitric oxide synthase type II (NOSII) in cirrhotic rats.Expression of NOSII mRNA was detected by real time RT-PCR. The activity of nitric oxide synthase and serum levels of NO, systemic and portal hemodynamics and degrees of cirrhosis were measured with high sensitive methods. Chinese traditional medicine tetrandrine
Hai, Wang, Xiao-Ping, Chen, Fa-Zu, Qiu
openaire   +2 more sources

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

Frontiers in Immunology, 2014
Macrophages play a paramount role in immunity and inflammation-associated diseases, including infections, cardiovascular diseases, obesity‐associated metabolic imbalances and cancer.
Zhihong eYang, Xiu-Fen eMing
doaj   +1 more source

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells [PDF]

American Journal of Physiology-Cell Physiology, 1999
In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-α (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Cruz, MT, Duarte, CB, Gonçalo, Margarida, Carvalho, AP, Lopes, MC   +4 more
openaire   +3 more sources