Results 1 to 10 of about 93,042 (311)

Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain. [PDF]

Exp Neurobiol, 2019
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory mechanisms responsible for the expression of the DHEA-synthesizing enzyme, cytochrome ...
Choi SR, Beitz AJ, Lee JH.
europepmc   +4 more sources

ALDH2 rs671 Variant Lowers Blood Pressure Via the Endothelial HSPA5–PIEZO1–eNOS Pathway [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The inactivating ALDH2 rs671 polymorphism, present in ≈8% of the global population and up to 30% to 50% of East Asian individuals, has been negatively associated with hypertension.
Huaqing Ye, Hongwei Yue, Shujian Wei, Kaiyi Wang, Kehui Yang, Han Du, Wentao Sang, Jialin Guo, Jingwen Wang, Yunyun Guo, Cheng Zhang, Sumei Cui, Feng Xu, Yuguo Chen   +13 more
doaj   +2 more sources

Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain [PDF]

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production.
João Cláudio Damasceno-Sá, Fernanda Silva de Souza, Thiago Alves Teixeira dos Santos, Fábio Conceição de Oliveira, Maria de Fátima Sarro da Silva, Raul Ramos Furtado Dias, Wanderley de Souza, Andrea Cristina Veto Arnholdt, Sergio Henrique Seabra, Renato Augusto DaMatta   +9 more
doaj   +1 more source

Parkia speciosa Hassk. Empty Pod Extract Alleviates Angiotensin II-Induced Cardiomyocyte Hypertrophy in H9c2 Cells by Modulating the Ang II/ROS/NO Axis and MAPK Pathway

Frontiers in Pharmacology, 2021
Cardiac hypertrophy is characteristic of heart failure in patients who have experienced cardiac remodeling. Many medicinal plants, including Parkia speciosa Hassk., have documented cardioprotective effects against such pathologies.
Hawa Nordin Siti, Hawa Nordin Siti, Juriyati Jalil, Ahmad Yusof Asmadi, Yusof Kamisah, Yusof Kamisah   +5 more
doaj   +1 more source

NEURONAL (TYPE I) NITRIC OXIDE SYNTHASE REGULATES NUCLEAR FACTOR ϰ B ACTIVITY AND IMMUNOLOGIC (TYPE II) NITRIC OXIDE SYNTHASE EXPRESSION [PDF]

Japanese Journal of Pharmacology, 1997
Nitric oxide subserves diverse physiologic roles in the nervous system. NO is produced from at least three different NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS, and immunologic NOS (iNOS). We show that nNOS is the predominant isoform constitutively expressed in glia.
H, Togashi, M, Sasaki, E, Frohman, E, Taira, R R, Ratan, T M, Dawson, V L, Dawson   +6 more
openaire   +2 more sources

Activation of Endothelial Nitric Oxide Synthase by the Angiotensin II Type 1 Receptor [PDF]

Endocrinology, 2006
Enhanced angiotensin II (AngII) action has been implicated in endothelial dysfunction that is characterized as decreased nitric oxide availability. Although endothelial cells have been reported to express AngII type 1 (AT1) receptors, the exact role of AT1 in regulating endothelial NO synthase (eNOS) activity remains unclear.
Hiroyuki, Suzuki, Kunie, Eguchi, Haruhiko, Ohtsu, Sadaharu, Higuchi, Sudhir, Dhobale, Gerald D, Frank, Evangeline D, Motley, Satoru, Eguchi   +7 more
openaire   +2 more sources

Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat

Biomedicines, 2022
This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings.
Rosemary Wangensteen, Manuel Gómez-Guzmán, Inmaculada Banegas, Isabel Rodríguez-Gómez, Rosario Jiménez, Juan Duarte, Joaquín García-Estañ, Félix Vargas   +7 more
doaj   +1 more source

The Antitumoral Effect of Paris Saponin II on Head and Neck Squamous Cell Carcinomas Mediated via the Nitric Oxide Metabolic Pathway

Frontiers in Cell and Developmental Biology, 2022
Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi, Wenwen Qi, Fangyuan Zhu, Min Wang, Zhenxiao Teng, Zhenxiao Teng, Runtong Xu, Yue Xi, Qiu Meng, Xinhao Wu, Xinhao Wu, Hui Zhao, Min Ma, Xiaozhi Hou, Baowei Wang, Xiaoming Li, Chengcheng Liu, Xiang Zhang, Fenglei Xu, Ming Xia, Ming Xia   +20 more
doaj   +1 more source

The kinetics and regulation of the induction of type II nitric oxide synthase and nitric oxide in human fetal glial cell cultures [PDF]

Molecular Psychiatry, 1997
Our understanding of how human glial cells are induced to produce nitric oxide and how the production is regulated may allow us to better design therapeutic strategies for treating inflammatory diseases of the central nervous system in man. Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in ...
M, Ding, J E, Merrill
openaire   +2 more sources

Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III [PDF]

Journal of Biological Chemistry, 2002
Homodimer formation activates all nitric-oxide synthases (NOSs). It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg. Here we compared three NOSoxy isozymes regarding dimer strength, interface composition, and the ability of L-Arg and H4B to ...
Koustubh, Panda, Robin J, Rosenfeld, Sanjay, Ghosh, Abigail L, Meade, Elizabeth D, Getzoff, Dennis J, Stuehr   +5 more
openaire   +2 more sources