Frontiers in Pharmacology, 2019 AimIt is well-established that angiotensin II exerts a dampening effect on the baroreflex within the nucleus tractus solitarii (NTS), the principal brainstem site for termination of baroreceptor afferents and which is densely populated with gamma ...
Laura Légat +6 more
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Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]
, 2009 Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R. +19 more
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Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes [PDF]
Journal of Biological Chemistry, 1996 Incubation of primary cultures of rat hepatocytes with lipopolysaccharide (LPS), S-[2,3-bis(palmitoyloxy)-(2-R,S)-propyl]-N-palmitoyl-(R)-Cys-Ser-Lys4 (TPP), a synthetic lipopeptide present in bacterial cell wall lipoproteins, or with phorbol 12,13-dibutyrate (PDBu) induced an increase in nitric oxide synthesis through the expression of type II nitric ...
Díaz-Guerra, María José +3 more
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Frontiers in Immunology, 2014 Macrophages play a paramount role in immunity and inflammation-associated diseases, including infections, cardiovascular diseases, obesity‐associated metabolic imbalances and cancer.
Zhihong eYang, Xiu-Fen eMing
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Increased hepatic expression of nitric oxide synthase type II in cirrhotic rats
World Journal of Gastroenterology, 2004 To determine the role and effect of nitric oxide synthase type II (NOSII) in cirrhotic rats.Expression of NOSII mRNA was detected by real time RT-PCR. The activity of nitric oxide synthase and serum levels of NO, systemic and portal hemodynamics and degrees of cirrhosis were measured with high sensitive methods. Chinese traditional medicine tetrandrine
Hai, Wang, Xiao-Ping, Chen, Fa-Zu, Qiu
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]
, 2005 Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin +3 more
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Haematologica, 2011 Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano +10 more
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Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue. [PDF]
PLoS ONE, 2017 Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones.
Tsuyoshi Uchiyama +5 more
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Angiogenesis "in vitro" of the healthy mouse heart under hypoxia : the role of Angiotensin II and Nitric Oxide [PDF]
, 2005 Angiogenesis is the process by which blood microvessels are formed from existing ones. Angiogenesis is required for development. It is also important for reducing myocardial hypoxia due to coronary and ischemic heart disease; in myocardial infarction ...
Munk, Veronica Cecilia
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Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells [PDF]
American Journal of Physiology-Cell Physiology, 1999 In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-α (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Cruz, MT +4 more
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