Results 41 to 50 of about 93,042 (311)

Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension

Clinical and Experimental Hypertension, 2020
Background: Capsaicin, a pungent component of chili pepper, has been reported to decrease blood pressure (BP) and to cause vasorelaxation via nitric oxide (NO) production.
Yukiko Segawa, Hiroko Hashimoto, Saki Maruyama, Miki Shintani, Hitomi Ohno, Yuko Nakai, Tomoko Osera, Nobutaka Kurihara   +7 more
doaj   +1 more source

The Role of Christine A Saponins Molecules in the Control of Mild Chronic Inflammation in Obesity Related with Type-II Diabetes Mellitus

مجله دانشکده پزشکی اصفهان, 2020
Obesity is always associated with chronic (low-grade) inflammation, which causes insulin-resistance in type-II diabetes mellitus. Dramatically, cholesterol level rises with starting diabetes and lower insulin level.
Ladan Ahmad-Khosravi-Choghakhor, Mohsen Sarafbidabad   +1 more
doaj   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin, Umbrello, Michele, Dyson, Alex, Singer, Mervyn   +3 more
core   +1 more source

Searching the ideal inhaled vasodilator: From nitric oxide to prostacyclin [PDF]

, 2002
Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians.
Kleen, Martin, Habler, Oliver, Zwissler, Bernhard, Welte, M., Kemming, Gregor, Kisch-Wedel, Hille   +5 more
core   +1 more source

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Scientific Reports, 2023
This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats.
Putcharawipa Maneesai, Jintanaporn Wattanathorn, Prapassorn Potue, Juthamas Khamseekaew, Siwayu Rattanakanokchai, Wipawee Thukham-Mee, Supaporn Muchimapura, Poungrat Pakdeechote   +7 more
doaj   +1 more source

A rapid and transient synthesis of nitric oxide (NO) by a constitutively expressed type II NO synthase in the guinea‐pig suprachiasmatic nucleus [PDF]

British Journal of Pharmacology, 2001
We have measured extracellular NO/NO2− concentrations in guinea‐pig suprachiasmatic nucleus (SCN) brain slices using fast cyclic voltammetry. A rapid and transient signal equivalent to 2.2±0.2 μM NO/NO2− (mean±s.e.mean, n=13) was detected at 1.26 V, the peak oxidation potential for NO, following local electrical stimulation (five pulses of 0.1 ms ...
S J, Starkey, A L, Grant, R M, Hagan
openaire   +2 more sources

Autophagy contributes to angiotensin II induced dysfunction of HUVECs

Clinical and Experimental Hypertension, 2021
Background: Signal transduction of Angiotensin II (Ang II) induced autophagy and its role in Ang II–induced dysfunction of HUVECs are still unclear. Methods: HUVECs are stimulated with different doses of Ang II (10-9-10-5 mol/L) for different time (6–48 ...
Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang   +7 more
doaj   +1 more source

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

eLife, 2021
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid flow ...
Ahmad F Alghanem, Javier Abello, Joshua M Maurer, Ashutosh Kumar, Chau My Ta, Susheel K Gunasekar, Urooj Fatima, Chen Kang, Litao Xie, Oluwaseun Adeola, Megan Riker, Macaulay Elliot-Hudson, Rachel A Minerath, Chad E Grueter, Robert F Mullins, Amber N Stratman, Rajan Sah   +16 more
doaj   +1 more source

Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway

Frontiers in Physiology, 2020
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including angiotensin type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species
Jing Ding, Jing Ding, Min Yu, Min Yu, Juncai Jiang, Juncai Jiang, Yanbei Luo, Yanbei Luo, Qian Zhang, Qian Zhang, Shengnan Wang, Fei Yang, Alei Wang, Alei Wang, Lingxiao Wang, Lingxiao Wang, Mei Zhuang, Shan Wu, Qifang Zhang, Yong Xia, Deqin Lu, Deqin Lu   +21 more
doaj   +1 more source

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

Redox Biology, 2021
Non-thermal plasma (NTP), an engineered technology to generate reactive species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells.
Li Jiang, Hao Zheng, Qinying Lyu, Shotaro Hayashi, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni   +12 more
doaj   +1 more source