Results 41 to 50 of about 1,819 (263)

The Role of Christine A Saponins Molecules in the Control of Mild Chronic Inflammation in Obesity Related with Type-II Diabetes Mellitus

مجله دانشکده پزشکی اصفهان, 2020
Obesity is always associated with chronic (low-grade) inflammation, which causes insulin-resistance in type-II diabetes mellitus. Dramatically, cholesterol level rises with starting diabetes and lower insulin level.
Ladan Ahmad-Khosravi-Choghakhor, Mohsen Sarafbidabad   +1 more
doaj   +1 more source

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Scientific Reports, 2023
This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats.
Putcharawipa Maneesai, Jintanaporn Wattanathorn, Prapassorn Potue, Juthamas Khamseekaew, Siwayu Rattanakanokchai, Wipawee Thukham-Mee, Supaporn Muchimapura, Poungrat Pakdeechote   +7 more
doaj   +1 more source

A rapid and transient synthesis of nitric oxide (NO) by a constitutively expressed type II NO synthase in the guinea‐pig suprachiasmatic nucleus [PDF]

British Journal of Pharmacology, 2001
We have measured extracellular NO/NO2− concentrations in guinea‐pig suprachiasmatic nucleus (SCN) brain slices using fast cyclic voltammetry. A rapid and transient signal equivalent to 2.2±0.2 μM NO/NO2− (mean±s.e.mean, n=13) was detected at 1.26 V, the peak oxidation potential for NO, following local electrical stimulation (five pulses of 0.1 ms ...
S J, Starkey, A L, Grant, R M, Hagan
openaire   +2 more sources

Release and elementary mechanisms of nitric oxide in hair cells

, 2010
The enzyme nitric oxide (NO) synthase, that produces the signaling molecule NO, has been identified in several cell types in the inner ear. However, it is unclear whether a measurable quantity of NO is released in the inner ear to confer specific ...
Song, Haitao, Smith, Peter J S, Yamoah, Ebenezer N, Lv, Ping, Eastwood, Emily, Yevgeniy, Petrov Y, Mu, Karen, Levic, Snezana, Wei, Dongguang, Zhu, Jun, Kim, Hyo Jeong, Choong-Ryoul, Sihn, Rodriguez-Contreras, Adrian   +12 more
core   +1 more source

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

eLife, 2021
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid flow ...
Ahmad F Alghanem, Javier Abello, Joshua M Maurer, Ashutosh Kumar, Chau My Ta, Susheel K Gunasekar, Urooj Fatima, Chen Kang, Litao Xie, Oluwaseun Adeola, Megan Riker, Macaulay Elliot-Hudson, Rachel A Minerath, Chad E Grueter, Robert F Mullins, Amber N Stratman, Rajan Sah   +16 more
doaj   +1 more source

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

, 2009
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E., Ingrid Fleming, Annemarieke E. Loot, Fißlthaler, Beate, Fleming, Ingrid, Judith G. Schreiber, Beate Fisslthaler, Schreiber, Judith G.   +7 more
core   +1 more source

Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway

Frontiers in Physiology, 2020
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including angiotensin type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species
Jing Ding, Jing Ding, Min Yu, Min Yu, Juncai Jiang, Juncai Jiang, Yanbei Luo, Yanbei Luo, Qian Zhang, Qian Zhang, Shengnan Wang, Fei Yang, Alei Wang, Alei Wang, Lingxiao Wang, Lingxiao Wang, Mei Zhuang, Shan Wu, Qifang Zhang, Yong Xia, Deqin Lu, Deqin Lu   +21 more
doaj   +1 more source

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

Redox Biology, 2021
Non-thermal plasma (NTP), an engineered technology to generate reactive species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells.
Li Jiang, Hao Zheng, Qinying Lyu, Shotaro Hayashi, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni   +12 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness [PDF]

Journal of Human Hypertension, 2007
Angiotensin II and nitric oxide belong to important factors in the functional and structural changes of vessel wall, leading to its increased stiffness. We investigated, whether common mutations of angiotensin II type 1 receptor (AGTR(1)) and endothelial nitric oxide synthase (eNOS) are associated with increased arterial stiffness. Two polymorphisms, A(
O, Mayer, J, Filipovský, M, Pesta, R, Cífková, M, Dolejsová, J, Simon   +5 more
openaire   +2 more sources