Results 41 to 50 of about 12,882,259 (299)

Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome

Heliyon, 2023
Vascular alterations induced by a high-fat diet (HFD) are involved in the development of hypertension. Galangin, a flavonoid, is the major active compound isolated from galangal and propolis.
Poungrat Pakdeechote, Anuson Poasakate, Patoomporn Prasatthong, Prapassorn Potue, Juthamas Khamseekaew, Putcharawipa Maneesai   +5 more
doaj   +1 more source

A rapid and transient synthesis of nitric oxide (NO) by a constitutively expressed type II NO synthase in the guinea‐pig suprachiasmatic nucleus [PDF]

British Journal of Pharmacology, 2001
We have measured extracellular NO/NO2− concentrations in guinea‐pig suprachiasmatic nucleus (SCN) brain slices using fast cyclic voltammetry. A rapid and transient signal equivalent to 2.2±0.2 μM NO/NO2− (mean±s.e.mean, n=13) was detected at 1.26 V, the peak oxidation potential for NO, following local electrical stimulation (five pulses of 0.1 ms ...
S J, Starkey, A L, Grant, R M, Hagan
openaire   +2 more sources

Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation

Frontiers in Immunology, 2018
Triggering or enhancing antitumor activity of tumor-associated macrophages is an attractive strategy for cancer treatment. We have previously shown that the cytokine interferon-γ (IFN-γ), a type II IFN, could synergize with toll-like receptor (TLR ...
Elisabeth Müller, Elisabeth Müller, Martin Speth, Panagiotis F. Christopoulos, Anna Lunde, Ajna Avdagic, Inger Øynebråten, Alexandre Corthay   +7 more
doaj   +1 more source

Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension

Clinical and Experimental Hypertension, 2020
Background: Capsaicin, a pungent component of chili pepper, has been reported to decrease blood pressure (BP) and to cause vasorelaxation via nitric oxide (NO) production.
Yukiko Segawa, Hiroko Hashimoto, Saki Maruyama, Miki Shintani, Hitomi Ohno, Yuko Nakai, Tomoko Osera, Nobutaka Kurihara   +7 more
doaj   +1 more source

Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T) and Diabetes Mellitus (Type II) among South Indians [PDF]

Oxidative Medicine and Cellular Longevity, 2011
The objective of the study is to find out whether the endothelial nitric oxide synthase (eNOS) G894T single-nucleotide polymorphism is associated with type 2 diabetes mellitus in South Indian (Tamil) population. A total number of 260 subjects comprising 100 type 2 diabetic mellitus patients and 160 healthy individuals with no documented history of ...
Angeline, T., Krithiga, H. R., Isabel, W., Asirvatham, A. J., Poornima, A.   +4 more
openaire   +2 more sources

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
core   +2 more sources

Autophagy contributes to angiotensin II induced dysfunction of HUVECs

Clinical and Experimental Hypertension, 2021
Background: Signal transduction of Angiotensin II (Ang II) induced autophagy and its role in Ang II–induced dysfunction of HUVECs are still unclear. Methods: HUVECs are stimulated with different doses of Ang II (10-9-10-5 mol/L) for different time (6–48 ...
Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang   +7 more
doaj   +1 more source

The Role of Christine A Saponins Molecules in the Control of Mild Chronic Inflammation in Obesity Related with Type-II Diabetes Mellitus

مجله دانشکده پزشکی اصفهان, 2020
Obesity is always associated with chronic (low-grade) inflammation, which causes insulin-resistance in type-II diabetes mellitus. Dramatically, cholesterol level rises with starting diabetes and lower insulin level.
Ladan Ahmad-Khosravi-Choghakhor, Mohsen Sarafbidabad   +1 more
doaj   +1 more source

Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet

Scientific Reports, 2023
This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats.
Putcharawipa Maneesai, Jintanaporn Wattanathorn, Prapassorn Potue, Juthamas Khamseekaew, Siwayu Rattanakanokchai, Wipawee Thukham-Mee, Supaporn Muchimapura, Poungrat Pakdeechote   +7 more
doaj   +1 more source

Release and elementary mechanisms of nitric oxide in hair cells

, 2010
The enzyme nitric oxide (NO) synthase, that produces the signaling molecule NO, has been identified in several cell types in the inner ear. However, it is unclear whether a measurable quantity of NO is released in the inner ear to confer specific ...
Song, Haitao, Smith, Peter J S, Yamoah, Ebenezer N, Lv, Ping, Eastwood, Emily, Yevgeniy, Petrov Y, Mu, Karen, Levic, Snezana, Wei, Dongguang, Zhu, Jun, Kim, Hyo Jeong, Choong-Ryoul, Sihn, Rodriguez-Contreras, Adrian   +12 more
core   +1 more source