Results 41 to 50 of about 175,774 (310)
Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
core +2 more sources
Autophagy contributes to angiotensin II induced dysfunction of HUVECs
Clinical and Experimental Hypertension, 2021 Background: Signal transduction of Angiotensin II (Ang II) induced autophagy and its role in Ang II–induced dysfunction of HUVECs are still unclear. Methods: HUVECs are stimulated with different doses of Ang II (10-9-10-5 mol/L) for different time (6–48 ...
Di Liu +7 more
doaj +1 more source
Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes [PDF]
Journal of Biological Chemistry, 1996 Incubation of primary cultures of rat hepatocytes with lipopolysaccharide (LPS), S-[2,3-bis(palmitoyloxy)-(2-R,S)-propyl]-N-palmitoyl-(R)-Cys-Ser-Lys4 (TPP), a synthetic lipopeptide present in bacterial cell wall lipoproteins, or with phorbol 12,13-dibutyrate (PDBu) induced an increase in nitric oxide synthesis through the expression of type II nitric ...
Díaz-Guerra, María José +3 more
openaire +2 more sources
Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]
, 2019 The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole +5 more
core +1 more source
Frontiers in Immunology, 2018 Triggering or enhancing antitumor activity of tumor-associated macrophages is an attractive strategy for cancer treatment. We have previously shown that the cytokine interferon-γ (IFN-γ), a type II IFN, could synergize with toll-like receptor (TLR ...
Elisabeth Müller +7 more
doaj +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources
Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension
Clinical and Experimental Hypertension, 2020 Background: Capsaicin, a pungent component of chili pepper, has been reported to decrease blood pressure (BP) and to cause vasorelaxation via nitric oxide (NO) production.
Yukiko Segawa +7 more
doaj +1 more source
مجله دانشکده پزشکی اصفهان, 2020 Obesity is always associated with chronic (low-grade) inflammation, which causes insulin-resistance in type-II diabetes mellitus. Dramatically, cholesterol level rises with starting diabetes and lower insulin level.
Ladan Ahmad-Khosravi-Choghakhor +1 more
doaj +1 more source
Microvascular alterations in hypertension and vascular aging [PDF]
, 2017 Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and
Battistoni, Allegra +5 more
core +1 more source
Scientific Reports, 2023 This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats.
Putcharawipa Maneesai +7 more
doaj +1 more source