Results 61 to 70 of about 93,042 (311)

A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes [PDF]

Osteoarthritis and Cartilage, 2008
Recent studies revealed a close connection between adipose tissue, adipokines and articular degenerative inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). The goal of this work was to investigate the activity of adiponectin in human and murine chondrocytes and to study its functional role in the modulation of nitric oxide
Lago, R., Gomez, R., Otero, M., Lago, F., Gallego, R., Dieguez, C., Gomez-Reino, J.J., Gualillo, O.   +7 more
openaire   +2 more sources

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology
T‐type voltage‐gated calcium channels (VGCCs) are comparatively understudied in large conduit artery function relative to the well‐characterized L‐type channel subtype.
Andrea Suarez, Sol Guerra‐Ojeda, Manuel Zarzoso, Marta Serna‐García, Jose M. Vila, Eva Serna, Maria D. Mauricio   +6 more
doaj   +1 more source

L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway

International Journal of Endocrinology, 2014
Rat studies demonstrated that type II diabetes mellitus (T2DM) decreases both the production and bioavailability of nitric oxide (NO). L-arginine (LA) provides the precursor for the production of NO.
Taylor Claybaugh, Sarah Decker, Kelly McCall, Yuriy Slyvka, Jerrod Steimle, Aaron Wood, Megan Schaefer, Jean Thuma, Sharon Inman   +8 more
doaj   +1 more source

Expression of nitric oxide synthase type II in the spinal cord under conditions producing thermal hyperalgesia

Journal of Chemical Neuroanatomy, 1996
There is evidence supporting spinal cord nitric oxide (NO) production in the mechanisms underlying hyperalgesia, presumed to arise from the activity of neuronal nitric oxide synthase type I (NOS I). Intrathecal administration of interleukin-1 beta and interferon-gamma to rats results in a thermal hyperalgesia which peaks at 2 h post-injection but which
Grzybicki, D., Gebhart, G.F., Murphy, S.
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Nitric Oxide Synthase 2 Polymorphisms (rs2779248T/C and rs1137933C/T) and the Risk of Type 2 Diabetes in Zahedan, Southeastern Iran

Iranian Journal of Public Health, 2018
Background: Nitric oxide (NO) has been associated with insulin resistance and type 2 diabetes (T2D). NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2 ...
Yasaman GARME, Mahdiyeh MOUDI, Ramin SARAVANI, Hamidreza GALAVI   +3 more
doaj  

Chloroquine potentially modulated innate immune response to Vibrio parahaemolyticus in RAW 264.7 macrophages

Food and Agricultural Immunology, 2021
Vibrio parahaemolyticus, as a vibriosis, causes huge losses to the aquaculture industry, food poisoning in humans and activates macrophages to induce pro-inflammatory cytokines.
Xifeng Qiao, Pingchao Li, Haoran Lin, Yong Zhang, Ying Zhu, Zhiyun Du, Danqi Lu   +6 more
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control [PDF]

, 2008
I have explored the role of nitric oxide (NO) and the distribution of its synthetic enzyme in neurons, nNOS, in vertebrate motor control. The CNS of Xenopus laevis tadpoles was used primarily in this investigation as a developmental model of neural ...
Molinari, Micol Ariella
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