Results 51 to 60 of about 12,882,259 (299)

Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness [PDF]

Journal of Human Hypertension, 2007
Angiotensin II and nitric oxide belong to important factors in the functional and structural changes of vessel wall, leading to its increased stiffness. We investigated, whether common mutations of angiotensin II type 1 receptor (AGTR(1)) and endothelial nitric oxide synthase (eNOS) are associated with increased arterial stiffness. Two polymorphisms, A(
O, Mayer, J, Filipovský, M, Pesta, R, Cífková, M, Dolejsová, J, Simon   +5 more
openaire   +2 more sources

Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]

, 2012
Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt, Volker Adams, Katharina Kandt, Matthias Blueher, Andreas Oberbach, Igor Buchwalow   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway

Frontiers in Physiology, 2020
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including angiotensin type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species
Jing Ding, Jing Ding, Min Yu, Min Yu, Juncai Jiang, Juncai Jiang, Yanbei Luo, Yanbei Luo, Qian Zhang, Qian Zhang, Shengnan Wang, Fei Yang, Alei Wang, Alei Wang, Lingxiao Wang, Lingxiao Wang, Mei Zhuang, Shan Wu, Qifang Zhang, Yong Xia, Deqin Lu, Deqin Lu   +21 more
doaj   +1 more source

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

eLife, 2021
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid flow ...
Ahmad F Alghanem, Javier Abello, Joshua M Maurer, Ashutosh Kumar, Chau My Ta, Susheel K Gunasekar, Urooj Fatima, Chen Kang, Litao Xie, Oluwaseun Adeola, Megan Riker, Macaulay Elliot-Hudson, Rachel A Minerath, Chad E Grueter, Robert F Mullins, Amber N Stratman, Rajan Sah   +16 more
doaj   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin, Umbrello, Michele, Dyson, Alex, Singer, Mervyn   +3 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Predictors of genetic polymorphisms in patients with arterial hypertension and ischemic heart disease

Endocrine Regulations
Objective. This study was aimed to develop a mathematical model for predicting the presence of pathological alleles of the angiotensin II receptor type 1 (AGTR1) (C1166C) and endothelial nitric oxide synthase (eNOS) (T786C) genes in patients with ...
Pidruchna Svitlana, Yarema Nadiya, Kuzmak Iryna, Prokopovych Olena, Kotsiuba Oksana, Sverstuk Andrii, Bahrii-Zaiats Oksana, Lykhatskyi Petro, Mudra Alla, Palytsya Lylya, Letniak Nataliya, Ostrivka Oksana, Yaroshenko Tetyana, Vasylyshyn Nadija   +13 more
doaj   +1 more source

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

Redox Biology, 2021
Non-thermal plasma (NTP), an engineered technology to generate reactive species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells.
Li Jiang, Hao Zheng, Qinying Lyu, Shotaro Hayashi, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni   +12 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source