The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]
, 1996 MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F. W. +18 more
core +1 more source
Nitric oxide and TNFα are critical regulators of reversible lymph node vascular remodeling and adaptive immune response. [PDF]
PLoS ONE, 2013 Lymph node (LN) vascular growth, at the level of the main arteriole, was recently characterized for the first time during infection. Arteriole diameter was shown to increase for at least seven days and to occur via a CD4(+) T cell dependent mechanism ...
Stephanie L Sellers +2 more
doaj +1 more source
Heliyon, 2023 Vascular alterations induced by a high-fat diet (HFD) are involved in the development of hypertension. Galangin, a flavonoid, is the major active compound isolated from galangal and propolis.
Poungrat Pakdeechote +5 more
doaj +1 more source
Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection [PDF]
Journal of Neuroimmunology, 1997 Intranasal inoculation with mouse hepatitis virus strain JHM (MHV-JHM) results in acute meningoencephalitis. We found NOS II mRNA expression in brains of acutely infected animals on days 5 through 7 after infection. In situ hybridization and immunohistochemistry demonstrated NOS II message and protein in infiltrating macrophages.
Grzybicki, Dana M +3 more
openaire +2 more sources
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]
, 2011 Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P. +19 more
core +1 more source
Frontiers in Immunology, 2018 Triggering or enhancing antitumor activity of tumor-associated macrophages is an attractive strategy for cancer treatment. We have previously shown that the cytokine interferon-γ (IFN-γ), a type II IFN, could synergize with toll-like receptor (TLR ...
Elisabeth Müller +7 more
doaj +1 more source
Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension
Clinical and Experimental Hypertension, 2020 Background: Capsaicin, a pungent component of chili pepper, has been reported to decrease blood pressure (BP) and to cause vasorelaxation via nitric oxide (NO) production.
Yukiko Segawa +7 more
doaj +1 more source
Autophagy contributes to angiotensin II induced dysfunction of HUVECs
Clinical and Experimental Hypertension, 2021 Background: Signal transduction of Angiotensin II (Ang II) induced autophagy and its role in Ang II–induced dysfunction of HUVECs are still unclear. Methods: HUVECs are stimulated with different doses of Ang II (10-9-10-5 mol/L) for different time (6–48 ...
Di Liu +7 more
doaj +1 more source
The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin +3 more
core +1 more source
Searching the ideal inhaled vasodilator: From nitric oxide to prostacyclin [PDF]
, 2002 Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians.
Kleen, Martin +5 more
core +1 more source