Results 31 to 40 of about 12,882,259 (299)

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase [PDF]

, 2009
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E., Ingrid Fleming, Annemarieke E. Loot, Fißlthaler, Beate, Fleming, Ingrid, Judith G. Schreiber, Beate Fisslthaler, Schreiber, Judith G.   +7 more
core   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F. W., G J Feng, Stott, D. I., Huang, Fangping, Feng, G.J., D I Stott, Feng, Gui Jie, Huang, F.P., G Lindop, Stott, David Ian, F Y Liew, Liew, F.Y., Lindop, George B M, F P Huang, Lindop, G., Huang, F. P., Liew, Fooyew, Stott, D.I., Feng, Guijie   +18 more
core   +6 more sources

Sex differences in angiotensin II- induced hypertension

Brazilian Journal of Medical and Biological Research, 2007
Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences
B. Xue, A.K. Johnson, M. Hay
doaj   +1 more source

Malfunction of Vascular Control in Lifestyle-Related Diseases: Mechanisms Underlying Endothelial Dysfunction in the Insulin-Resistant State

Journal of Pharmacological Sciences, 2004
It is tempting to speculate that increased vasoconstriction and loss of endothelium-dependent vasodilation might be etiological factors of elevated blood pressure in the insulin-resistant state.
Kazuya Shinozaki, Kazuhide Ayajiki, Atsunori Kashiwagi, Masahiro Masada, Tomio Okamura   +4 more
doaj   +1 more source

Nitric oxide synthase:non-canonical expression patterns [PDF]

, 2014
Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns ...
Anita C. Thomas, Mattila, Joshua, Mattila eJoshua, Thomas, Anita C, Mattila T Joshua, Joshuat Mattila, Joshua T. Mattila, Anita Coral Thomas, Anita C Thomas   +8 more
core   +1 more source

Nitric oxide-mediated modulation of the murine locomotor network [PDF]

, 2014
CD was supported by a BBSRC studentshipSpinal motor control networks are regulated by neuromodulatory systems to allow adaptability of movements. The present study aimed to elucidate the role of nitric oxide (NO) in the modulation of mammalian spinal ...
Miles, Gareth Brian, Foster, Joshua David, Sillar, Keith Thomas, Dunford, Catherine   +3 more
core   +1 more source

Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects [PDF]

, 2004
Background: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic heart disease (IHD), but data from published studies with individually low statistical power are conflicting.
Humphries, S.E., Bautista, Leonelo E, Humphries, Steve E, Bautista, L.E., Casas, J.P., Hingorani, Aroon D, Casas, Juan P, Hingorani, A.D., J. P. Casas   +8 more
core   +1 more source

Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection [PDF]

Journal of Neuroimmunology, 1997
Intranasal inoculation with mouse hepatitis virus strain JHM (MHV-JHM) results in acute meningoencephalitis. We found NOS II mRNA expression in brains of acutely infected animals on days 5 through 7 after infection. In situ hybridization and immunohistochemistry demonstrated NOS II message and protein in infiltrating macrophages.
Grzybicki, Dana M, Kwack, KyuBum, Perlman, Stanley, Murphy, Sean P   +3 more
openaire   +2 more sources

Nitric oxide and TNFα are critical regulators of reversible lymph node vascular remodeling and adaptive immune response. [PDF]

PLoS ONE, 2013
Lymph node (LN) vascular growth, at the level of the main arteriole, was recently characterized for the first time during infection. Arteriole diameter was shown to increase for at least seven days and to occur via a CD4(+) T cell dependent mechanism ...
Stephanie L Sellers, Akiko Iwasaki, Geoffrey W Payne   +2 more
doaj   +1 more source

Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control [PDF]

, 2008
I have explored the role of nitric oxide (NO) and the distribution of its synthetic enzyme in neurons, nNOS, in vertebrate motor control. The CNS of Xenopus laevis tadpoles was used primarily in this investigation as a developmental model of neural ...
Molinari, Micol Ariella
core   +2 more sources