Results 21 to 30 of about 508,056 (310)

Nitric oxide and nitric oxide synthase in Huntington's disease [PDF]

Journal of Neuroscience Research, 2001
AbstractNitric oxide (NO) is a biologically active inorganic molecule produced when the semiessential amino acid l‐arginine is converted to l‐citrulline and NO via the enzyme nitric oxide synthase (NOS). NO is known to be involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function ...
openaire   +2 more sources

Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy

Cardiovascular Ultrasound, 2006
Background Endothelial nitric oxide synthase produces nitric oxide which is involved in many physiologic regulatory functions. Variable number of tandem repeats in intron 4 of endothelial nitric oxide synthase gene are reported to be associated with ...
Arslan Erol, Barcin Cem, Sezer Murat, Ozbek Ugur, Ekmekci C Gokhan, Olcay Ayhan, Boztosun Bilal, Nisanci Yilmaz   +7 more
doaj   +1 more source

Examination of the different medicine effects at MDAH-2774 human ovary cancer three dimensional cell culture with nitric oxide synthase changing

Cerrahpaşa Medical Journal, 2013
Objectives: The purpose of our study is to examine the effects of the various medicines at the three dimensional MDAH-2774 human ovary cancer culture with cell proliferation and nitric oxide synthase changing.
Şule Ayla, Gülperi Öktem, Ayhan Bilir
doaj   +1 more source

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

Frontiers in Immunology, 2014
Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses.
Meera Rath, I. Müller, P. Kropf, E. Closs, M. Munder   +4 more
semanticscholar   +1 more source

Nitric oxide synthases in mammals [PDF]

Biochemical Journal, 1994
Nitric oxide is an inorganic free radical gas, of formula *N=O (abbreviated as NO). The discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L-arginine as a transcellular signal [1-4] was initially received by most biologists with considerable scepticism.
R G, Knowles, S, Moncada
openaire   +2 more sources

ACTIVITY MODULATION OF VARIOUS NITRIC OXIDE SYNTASES AS AN APPROACH TO ENDOTHELIAL DYSFUNCTION THERAPY

Фармация и фармакология (Пятигорск), 2022
Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted the attention of researchers at the end of the 19th century.
D. V. Kurkin, E. E. Abrosimova, D. A. Bakulin, N. S. Kovalev, M. A. Dubrovina, A. V. Borisov, A. V. Strygin, E. I. Morkovin, I. N. Tyurenkov   +8 more
doaj   +1 more source

Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase

BMC Gastroenterology, 2002
Background Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. Methods Wistar
Williamson Robin CN, Habib Nagy A, Virlos Ioannis T, Serracino-Inglott Ferdinand, Mathie Robert T   +4 more
doaj   +1 more source

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

Journal of Biological Chemistry, 1994
The promoter of the murine gene encoding inducible nitric oxide synthase (iNOS) contains an NF-kappa B site beginning 55 base pairs upstream of the TATA box, designated NF-kappa Bd.
Q. Xie, Y. Kashiwabara, C. Nathan
semanticscholar   +1 more source

The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis

Toxins, 2013
The aim of the study was to verify the hypothesis that intoxication with low doses of mycotoxins leads to changes in the mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes in tissues of the gastrointestinal tract and the ...
Magdalena Gajęcka, Ewa Stopa, Michał Tarasiuk, Łukasz Zielonka, Maciej Gajęcki   +4 more
doaj   +1 more source

Effects of Chitosan on the Secretion of Cytokines and Expression of Inducible Nitric Oxide Synthase mRNA in Peritoneal Macrophages of Broiler Chicken

Brazilian Archives of Biology and Technology, 2014
An in vitro experiment was conducted to study the effects of chitosan on the secretion of cytokines and expression of inducible nitric oxide synthase mRNA in peritoneal macrophages of broiler chicken.
Huiying Li, Binlin Shi, Sumei Yan, Tianzhang Zhao, Junliang Li, Xiaoyu Guo   +5 more
doaj   +1 more source