Results 21 to 30 of about 181,047 (262)

Role of Asymmetric Dimethylarginine in Psychiatric Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2014
Asymmetric dimethylarginine has been a post-translational modified form of the aminoasid arginine. Being a competitive inhibitor of nitric oxide synthase enzyme, makes asymmetric dimethylarginine important.
Selma Bozkurt Zincir, Serkan Zincir
doaj   +1 more source

Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS.

PLoS ONE, 2014
BackgroundFractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain.ObjectiveTo investigate whether fractional exhaled nitric oxide is
Abraham B Roos, Michiko Mori, Reidar Grönneberg, Christina Österlund, Hans-Erik Claesson, Jan Wahlström, Johan Grunewald, Anders Eklund, Jonas S Erjefält, Jon O Lundberg, Magnus Nord   +10 more
doaj   +1 more source

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundNitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide.
Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer, Guangshuo Zhu, Virginia S. Hahn, Djahida Bedja, Alice Recalde, Drew Duglan, Keith M. Channon, Barbara Casadei, David A. Kass   +10 more
doaj   +1 more source

Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review

Antioxidants, 2023
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely ...
Gabriele Serreli, Monica Deiana
doaj   +1 more source

Prognostic value of pro-inflammatory markers at the preoperative stage in Algerian women with breast cancer

Forum of Clinical Oncology
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) are widely used to assess patient’s outcome in many ...
Zergoun Ahmed Amine, Braikia Syhem, Boubnider Mohsen Wahib, Bouzid Kamel, Touil-Boukoffa Chafia   +4 more
doaj   +1 more source

Inducible nitric oxide synthase links NF-κB to PGE₂ in polyunsaturated fatty acid altered fibroblast in-vitro wound healing

Lipids in Health and Disease, 2005
Background This study investigated mechanisms of altered fibroblast collagen production induced by polyunsaturated fatty acids. 3T3-Swiss fibroblasts were grown in medium containing either eicosapentaenoic or arachidonic acid.
Turek John J, Jia Yi
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Nitric oxide synthase activity and peroxynitrite content in cells of rat’s mucous coat of stomach under experimental stress-induced ulcer

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2009
Nitric oxide synthase activity in gastric mucosal cells as well as peroxynitrite generation in experimental stress-induced gastric ulcer formation in rats were studied.
I. S. Maksymovych, M. V. Mylenko, O. V. Drobinska, L. I. Ostapchenko   +3 more
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source