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EXPRESSION OF NITRIC OXIDE SYNTHASE TYPE II WITH CEREBRAL TRAUMA
Journal of Neuropathology and Experimental Neurology, 1996 Dana M. Grzybicki +2 more
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Copper induces type II nitric oxide synthase in vivo
Free Radical Biology and Medicine, 2003Intravenous administration of copper (up to a final concentration of ca. 35 micromol/l in the plasma) led to a progressive, dramatic fall of mean arterial pressure in rats. Copper-induced pressure changes were comparable to those elicited by 2 mg/kg LPS, and were greatly prevented by previous infusion of the inducible NOS (NOS-II) inhibitors ...
CUZZOCREA S +4 more
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Leptin induces nitric oxide synthase type II in C6 glioma cells
Neuroscience Letters, 2005 Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation products of NO (NO2(-) and NO3 ...
Giuseppina Mattace Raso +8 more
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Type II nitric oxide synthase activity is cardio-protective in experimental sepsis
European Journal of Pharmacology, 2003Overproduction of nitric oxide (NO) via the induction of NO synthase (NOS) II is implicated in the pathogenesis of the refractory hypotension that characterizes septic shock. However, clinical trials of nonselective NOS inhibitors have failed to afford a mortality benefit in patients with sepsis, and in those with depressed left ventricular function ...
Suzanna, Price +3 more
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Nitric Oxide Synthase Type II mRNA Stability Is Translation‐ and Transcription‐Dependent
Journal of Neurochemistry, 1996Abstract: Nitric oxide synthase (NOS) type II is induced in many cell types in response to cytokines or endotoxin. The duration of type II NOS mRNA expression in astroglial cells and macrophages in vitro is brief, even in the continuous presence of inducers, and their removal dramatically accelerates mRNA decay.
S K, Park, S, Murphy
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Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats
Life Sciences, 2003The goals of this study were to determine the effects of type II diabetes mellitus on nitric oxide synthase-dependent responses of cerebral arterioles and on endothelial nitric oxide synthase (eNOS) protein in cerebral arterioles. We examined dilatation of cerebral (pial) arterioles in 13-15 week old male lean and diabetic obese Zucker rats in response
RoseAnn M, Schwaninger +2 more
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Canadian Journal of Physiology and Pharmacology, 1995
Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit type II NOS ...
W R, Tracey +3 more
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Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit type II NOS ...
W R, Tracey +3 more
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Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma
British Journal of Oral and Maxillofacial Surgery, 2000Prolonged nitric oxide (NO) production by the enzyme type II nitric oxide synthase (NOS2) has been implicated in angiogenesis and metastasis of human cancers. In animal models, wild-type p53 (but not mutant) protein results in down-regulation of NOS2 expression, which reduces both tumour growth and dissemination.
P A, Brennan +6 more
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Journal of Oral Pathology & Medicine, 2001 Abstract: In tumour biology, nitric oxide (NO) has a complex array of concentration‐dependent actions, including both inhibitory and promoting effects. It is thought that the levels of NO found in many human cancers lead to enhanced angiogenesis and tumour dissemination. In the current study, we assessed the immunohistochemical expression of the enzyme
Peter A. Brennan +4 more
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Neuroscience Letters, 2002
Nitric oxide synthase inhibitors have been regarded as potentially beneficial for psychiatric disorders such as depression and schizophrenia, though little is known about how nitric oxide synthases are affected by psychotropic drugs in the brain. Using reverse transcription-polymerase chain reaction analysis, we investigated the effects of short- and ...
Eiji, Suzuki +4 more
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Nitric oxide synthase inhibitors have been regarded as potentially beneficial for psychiatric disorders such as depression and schizophrenia, though little is known about how nitric oxide synthases are affected by psychotropic drugs in the brain. Using reverse transcription-polymerase chain reaction analysis, we investigated the effects of short- and ...
Eiji, Suzuki +4 more
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