Results 91 to 100 of about 69,950 (233)

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Exercise, cognition and Alzheimer’s disease: More is not necessarily better [PDF]

, 2005
Regional hypoperfusion, associated with a reduction in cerebral metabolism, is a hallmark of Alzheimer’s disease (AD) and contributes to cognitive decline. Cerebral perfusion and hence cognition can be enhanced by exercise.
Adlard, Alessi, Anton, Attwell, Baumbach, Bierman, Carmeliet, Chen, Chen, Churchill, Cohen, Colcombe, Cooke, Corder, Cott, Critchley, Cumming, Daley, De la Torre, Dick Swaab, Diesfeldt, Dubelaar, Eldridge, Endres, Erik Scherder, Farkas, Fedele, Fernández-Vizarra, Folstein, Fratiglioni, Friedman, Graham, Guigoz, Hamel, Harkany, Hayward, Hellström, Herrmann, Herrmann, Hoffman, Huang, Hönigfeld, Iadecola, Ide, Ide, Ide, Jagust, Johnson, Jørgensen, Katz, Keller, Kivipelto, Koike, Koistinaho, Kubes, Kurosawa, Launer, Laura Eggermont, Lawton, Lazowski, Lehtovirta, Liesi, Lijnen, Lindenmuth, MacRae, Martel, Matsuda, Matsuda, Maxwell, Melchor, Meltzer, Meyer, Miklossy, Monji, Morgan, Moro, Mulder, Muldowney, Nagahama, Nagai, Nakajima, Namazi, Naso, Palleschi, Palmer, Parihar, Paul Luiten, Petersen, Plutchik, Pober, Pott, Powell, Prager, Prunell, Raven, Reiman, Reitan, Rolland, Roth, Salehi, Scherder, Schini-Kerth, Selley, Skoog, Smith, Sobel, Spinler, Srikiatkhachorn, Suzuki, Swaab, Swaab, Swaab, Swain, Tappen, Tappen, Teri, Tinetti, Tong, Tong, Tsolaki, Tucker, Tucker, Ueda, Ushijima, Van de Winckel, Van Dyck, Van Gelder, Wang, Warkentin, Wechsler, Wechsler, Weller, Wenk, Whelton, White, Wilson, Wolf, Zarit   +137 more
core   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

The role of nitric-oxide-synthase-derived nitric oxide in multicellular traits of Bacillus subtilis 3610: biofilm formation, swarming, and dispersal

BMC Microbiology, 2011
Background Bacillus subtilis 3610 displays multicellular traits as it forms structurally complex biofilms and swarms on solid surfaces. In addition, B.
Lamprecht-Grandio María, Enning Dennis, Beutler Martin, Schreiber Frank, Zafra Olga, González-Pastor José, de Beer Dirk   +6 more
doaj   +1 more source

S-nitrosylation of NF-kB p65 inhibits TSH-induced Na+/I- symporter expression [PDF]

, 2015
Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces thyrotropin (TSH)-stimulated thyroid specific gene expression ...
Bocco, Jose Luis, Lucero, Ariel Maximiliano, Masini, Ana María, Montesinos, Maria del Mar, Nazar, Magalí, Nicola, Juan Pablo, Pellizas, Claudia Gabriela, Peyret, Victoria, Romero, Jorge Miguel   +8 more
core   +3 more sources

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. [PDF]

, 2016
BackgroundBreast cancer is a complex heterogeneous disease where many distinct subtypes are found. Younger African American (AA) women often present themselves with aggressive form of breast cancer with unique biology which is very difficult to treat ...
Chaudhuri, Gautam, Kim, Jinna, Martinez, Luis, Pervin, Shehla, Singh, Rajan, Thames, Easter   +5 more
core   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara, Gaetano, Carlo, Mai, Antonello, Martelli, Fabio, Spallotta, Francesco, Valente, Sergio, Zeiher, Andreas Michael   +6 more
core   +2 more sources