Results 201 to 210 of about 69,950 (233)
American Journal of Respiratory Cell and Molecular Biology, 1995 Prolonged hypoxia in the adult rat causes a decline in endothelium-derived nitric oxide (NO) production in the pulmonary circulation. To evaluate whether this is related to a decrease in endothelial NO synthase (NOS-III) expression, we determined the effects of hypobaric hypoxia (7 or 21 days) on NOS-III gene expression in adult rat lung. Neuronal NOS (
P. A. Nisen +8 more
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Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1994 The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of ...
Timothy S. Brannon +7 more
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Regulation and Dysregulation of Constitutive Nitric Oxide Synthases Types I and III
, 1995 Mammalian cells synthesize nitric oxide (NO) from l-arginine by NO synthases (NOS), members of the cytochrome P450 gene family. NO represents the best understood member of a novel class of redox-active transmembrane and intracellular signaling molecules that may also include CO and oxygen radicals.
H. H. H. W. Schmidt +2 more
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Gene Therapy, 2015 Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoblastoma cells. The study developed gene therapy designed to specifically overexpress NOS-3 in cultured hepatoma cells, and in tumors derived from orthotopically implanted tumor cells in fibrotic livers. Liver
Raúl González +12 more
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Placenta, 1998 Expression of endothelial nitric oxide synthase (eNOS) has been localized to the villous syncytiotrophoblasts suggesting that NO release from these cells could prevent platelet adhesion and aggregation in the intervillous space. Hypoxia- or inflammation-dependent changes in the release of this vasoactive substance may result in thrombus formation and ...
Johannes C. Huber +6 more
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Histochemistry and Cell Biology, 2003 Endothelial nitric oxide synthase (eNOS) or NOS-III in the endothelium catalyzes production of nitric oxide (NO). Nitric oxide diffuses freely into vascular smooth muscle, where it activates soluble guanylate cyclase (sGC) to produce guanosine 3',5'-cyclic monophosphate (cGMP) and causes vasorelaxation.
Peter A. Nickerson +4 more
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Journal of neurocytology, 1998 Ultrastructural localisation of type I (neuronal) and type III (endothelial) isoforms of nitric oxide synthase in perivascular nerve fibres (axons) and endothelial cells was studied in the Wistar rat cerebral basilar artery, using monoclonal antibodies either to type I or type III nitric oxide synthase and post-embedding colloidal-gold ...
A. Loesch, Geoffrey Burnstock
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Placenta, 1997 We have found in a previous study that 5-50 microM tetrahydrobiopterin (BH4) stimulated 1.2-2.5-fold Ca(2+)-dependent nitric-oxide synthase (NOS) activity in homogenates prepared from primordial human placentae. Now we report on the dramatic, about sixfold, activating effect of BH4 on this activity measured in microsomal preparations.
Zoltán Kukor +2 more
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Enhanced expression of type III (endothelial) nitric oxide synthase in preeclamptic placentas
Journal of the Society for Gynecologic Investigation, 1995 Celeste Sheppard
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Journal of the Society for Gynecologic Investigation, 1998 Jie Zhang, J Figueroa, G Massmann
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