Results 251 to 260 of about 129,732 (281)

Expression of endothelial (Type III) nitric oxide synthase in cytotrophoblastic cell lines: Regulation by hypoxia and inflammatory cytokines

Placenta, 1998
Expression of endothelial nitric oxide synthase (eNOS) has been localized to the villous syncytiotrophoblasts suggesting that NO release from these cells could prevent platelet adhesion and aggregation in the intervillous space. Hypoxia- or inflammation-dependent changes in the release of this vasoactive substance may result in thrombus formation and ...
H, Kiss, C, Schneeberger, W, Tschugguel, H, Lass, J C, Huber, P, Husslein, M, Knöfler   +6 more
openaire   +3 more sources

Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung.

American Journal of Respiratory Cell and Molecular Biology, 1995
Prolonged hypoxia in the adult rat causes a decline in endothelium-derived nitric oxide (NO) production in the pulmonary circulation. To evaluate whether this is related to a decrease in endothelial NO synthase (NOS-III) expression, we determined the effects of hypobaric hypoxia (7 or 21 days) on NOS-III gene expression in adult rat lung. Neuronal NOS (
P W, Shaul, A J, North, T S, Brannon, K, Ujiie, L B, Wells, P A, Nisen, C J, Lowenstein, S H, Snyder, R A, Star   +8 more
openaire   +3 more sources

Direct Effect of Temperature on the Catalytic Activity of Nitric Oxide Synthases Types I, II, and III

Nitric Oxide, 1999
The effect of temperature (between 5.0 and 45.0 degrees C) on the catalytic activity of nitric oxide synthases types I, II, and III (NOS-I, NOS-II, and NOS-III, respectively) has been investigated, at pH 7.5. The value of V(max) for NOS-I activity increases from 1.8 x 10(1) pmol min(-1) mg(-1), at 5.0 degrees C, to 1.8 x 10(2) pmol min(-1) mg(-1), at ...
VENTURINI G, COLASANTI, Marco, FIORAVANTI E, BIANCHINI A, ASCENZI P.   +4 more
openaire   +5 more sources

Activation and dimerization of type III nitric oxide synthase by submicromolar concentrations of tetra hydrobiopterin in microsomal preparations from human primordial placenta

Placenta, 1997
We have found in a previous study that 5-50 microM tetrahydrobiopterin (BH4) stimulated 1.2-2.5-fold Ca(2+)-dependent nitric-oxide synthase (NOS) activity in homogenates prepared from primordial human placentae. Now we report on the dramatic, about sixfold, activating effect of BH4 on this activity measured in microsomal preparations.
M, Tóth, Z, Kukor, M, Sahin-Tóth
openaire   +3 more sources

Paracrine role of soluble guanylate cyclase and type III nitric oxide synthase in ovine fetal pulmonary circulation: a double labeling immunohistochemical study

Histochemistry and Cell Biology, 2003
Endothelial nitric oxide synthase (eNOS) or NOS-III in the endothelium catalyzes production of nitric oxide (NO). Nitric oxide diffuses freely into vascular smooth muscle, where it activates soluble guanylate cyclase (sGC) to produce guanosine 3',5'-cyclic monophosphate (cGMP) and causes vasorelaxation.
Ching, Tzao, Peter A, Nickerson, James A, Russell, Bernice K, Noble, Robin H, Steinhorn   +4 more
openaire   +3 more sources

Perivascular nerve fibres and endothelial cells of the rat basilar artery: immuno-gold labelling of antigenic sites for type I and type III nitric oxide synthase

Journal of Neurocytology, 1998
Ultrastructural localisation of type I (neuronal) and type III (endothelial) isoforms of nitric oxide synthase in perivascular nerve fibres (axons) and endothelial cells was studied in the Wistar rat cerebral basilar artery, using monoclonal antibodies either to type I or type III nitric oxide synthase and post-embedding colloidal-gold ...
A, Loesch, G, Burnstock
openaire   +3 more sources

Enhanced expression of type III (endothelial) nitric oxide synthase in preeclamptic placentas

Journal of the Society for Gynecologic Investigation, 1995
Celeste Sheppard
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Differential regulation by estrogen of type I and type III Nitric Oxide Synthase (NOS) mRNA expression in the uterus of non pregnant sheep

Journal of the Society for Gynecologic Investigation, 1998
J FIGUEROA, J ZHANG, G MASSMANN, C MIRABILE   +3 more
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Expression of type I and type III Nitric Oxide Synthase (NOS) mRNA in the uterus of the pregnant sheep during the last third of gestation

Journal of the Society for Gynecologic Investigation, 1998
J ZHANG, G MASSMANN, J FIGUEROA
openaire   +2 more sources

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Nonpregnant sheep uterine type I and type III nitric oxide synthase expression is differentially regulated by estrogen.

Biology of reproduction, 1999
The aim of this study was to characterize the effect of estrogen on the expression of neuronal and endothelial isoforms of nitric oxide (NO) synthase (NOS) in myometrium, endometrium, and caruncle (nonglandular endometrium) in nonpregnant sheep. Twenty sheep were castrated during synchronized estrus (Days 14-16) and 4 days after surgery treated i.v ...
J, Zhang, G A, Massmann, C P, Mirabile, J P, Figueroa   +3 more
openaire   +1 more source