Results 231 to 240 of about 4,125,363 (309)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Ammonia fumigation combined with nitrogen inhibitor reduces root-knot nematode populations and N₂O emission but not bacterial alpha diversity. [PDF]

Front Microbiol
Shi F, Fu J, Li P, Li X, Liu J, Zhu Y.
europepmc   +1 more source

Editorial: thematic issue on microbial ecotoxicology of contaminants of emerging concern. [PDF]

FEMS Microbiol Ecol
Duperron S, Vuilleumier S, Brandt KK, Schmitt-Jansen M, Corcoll N.   +4 more
europepmc   +1 more source

Machine learning-based QSAR modeling assay for the nitrification inhibition of 2,4,5-trichloroaniline-derived eco-friendly Schiff bases. [PDF]

RSC Adv
Mondal T, Kumar R, Kumar R, Kumar R, Mukherjee S, Mridha N, Laskar N, Das A, Basak P, Singha A, Sinha K, Shakyawar DB.   +11 more
europepmc   +1 more source

Reconciling nitrogen fertilization effects on soil nitrification with acidification. [PDF]

Nat Commun
Wu L, Huang Y, Huang Y, Wang J, Lu L, Uwiragiye Y, Chen M, Tang Q, Fallah N, Liu Z, Jing H, Elrys AS, Qian Y, Cheng Y, Cai Z, Chang SX, Xu M, Müller C.   +17 more
europepmc   +1 more source

Ecophysiological niche expansion driven by biofilm lifestyle in an archaeal soil nitrifier

Pribasnig T, Dreer M, Luo Z, Malits A, Hodgskiss LH, Schleper C.   +5 more
europepmc   +1 more source

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Addressing challenges associated with nitrification inhibitors.

Trends in Microbiology
Despite global yield benefits from the use of nitrification inhibitors (NIs), the uncertainties and limitations surrounding NIs warrant more attention.
Yong Zhang, Diego Abalos, Xiaoli Cheng
semanticscholar   +3 more sources

The win-win effects of nitrification inhibitors on soil-crop systems: Decreasing carbendazim residues but promoting soil bacterial community diversities and stabilities and crop yields.

Journal of Hazardous Materials, 2023
Applying nitrogen (N)-cycling inhibitors is an effective measure to improve N fertilizer utilization efficiency, but the effects of N-cycling inhibitors on fungicide residues in soil-crop systems are unclear.
Tao Guo, P. O'Connor, Xin-Lin Zhao, Tang-Rong Zhou, Yan Wang, Man-Yun Zhang   +5 more
semanticscholar   +1 more source

Using nitrification inhibitors and deep placement to tackle the trade‐offs between NH3 and N2O emissions in global croplands

Global Change Biology, 2022
Ammonia (NH3) and nitrous oxide (N2O) are two important air pollutants that have major impacts on climate change and biodiversity losses. Agriculture represents their largest source and effective mitigation measures of individual gases have been well ...
Chong Zhang, Xiao-Zong Song, Ya-Qian Zhang, Dan Wang, R. Rees, X. Ju   +5 more
semanticscholar   +1 more source