DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
Konkurrenzreaktionen bei [3+2]-Cycloadditionen [1] Abfangreaktionen von Nitril-yliden mit 1.1-Diphenylethylen [2] / Competition between [3+2] Cycloaddition and 1,3-Addition Reactions [1] Trapping Reactions of Nitrile Ylides with 1,1-Diphenylethylene [2] [PDF]
, 1980 Klaus Burger +2 more
openalex +1 more source
Advanced Science, EarlyView.The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
Stability studies of isothiocyanates and nitriles in aqueous media [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2015 This is the first report to assess the stability of authentic commercial isothiocyanates and nitriles incubated anaerobically at 37 °C over 24 hrs in various aqueous solutions including nutrient broths with/without the presence of bacterial cells, and ...
Vijitra Luang-In, John Trevor Rossiter
doaj
Preparation of heterocyclic block copolymer from perfluoroalkylene oxide alpha, omega-diamidoximes [PDF]
, 1979 Diamidoxime monomers are intermolecularly and thermally condensed to form a heat and chemical resistant polymer containing 1,2,4-oxadiazole linkages with identical bivalent organic radicals or any combination of bivalent organic radicals selected from ...
Iannone, M., Ross, L. O., Rosser, R. W.
core +1 more source
, 2013 Samples of pristine Solar System material found in meteorites and interplanetary dust particles are highly enriched in (15)N. Conspicuous nitrogen isotopic anomalies have also been measured in comets, and the (14)N/(15)N abundance ratio of the Earth is ...
Bizzocchi, Luca +3 more
core +1 more source
THE EFFECT OF SODIUM THIOSULFATE AND HYDROXO-COBALAMIN ON RATS FED NITRILE-RICH OR GOITRIN-RICH RAPESEED MEALS [PDF]
, 1980 I. K. Paik, A.R. Robblee, D.R. Clandinin
openalex +1 more source
Growth‐Like Swelling of 2D Precursors for Efficient Fabrication of Complex 3D Microstructures
Advanced Science, EarlyView.The growth‐like swelling process fills photocured polymers into the elastomeric microstructures, inducing a significant swelling deformation of microstructures that can be maintained in the absence of solvents. The growth‐like swelling process breaks through the dependence of swelling deformation on the solvents, thereby expanding the application of 3D
Xinkai Zhu +13 more
wiley +1 more source
The Synthetic Potentialities of Nitriles in Heterocyclic Synthesis
, 1987 Sherif Mourad Sherif +2 more
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