Results 111 to 120 of about 62,179 (283)

Nitrile reductase as a biocatalyst : opportunities and challenges

, 2014
Nitrile-containing compounds are widely manufactured and extensively used in the chemical and pharmaceutical industries as synthetic intermediates or precursors.
Liang, Zhao-Xun, Sutton, Peter W., Koh, Siew Lee, Yang, Lifeng   +3 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Biochemical characterization of two Brassica oleracea nitrile-specifier proteins

Frontiers in Plant Science
Brassica oleracea vegetables (e. g. cabbages) form bioactive isothiocyanates (ITCs) from glucosinolate (GLS) hydrolysis. However, enzymatic activity, acidic pH (below pH 5), and ferrous ions (Fe2+) can promote nitrile release, reducing the ITC amount. In
Kudzai Gracious Mbudu, Kudzai Gracious Mbudu, Katja Witzel, Ute Wittstock, Frederik Börnke, Frederik Börnke, Franziska Sabine Hanschen, Franziska Sabine Hanschen   +7 more
doaj   +1 more source

Comprehensive analysis of nitrile probe IR shifts and intensities in proteins: experiment and critical evaluation of simulations [PDF]

Molecular dynamics (MD) simulations are frequently carried out for proteins to investigate the role of electrostatics in their biological function. The choice of force field (FF) can significantly alter the MD results as the simulated local electrostatic
Steven G., Boxer, Jacek, Kozuch, Jacob M., Kirsh, Jared Bryce, Weaver   +3 more
core   +2 more sources

A Dispersant‐Driven Carbon‐Binder Domains Homogeneity in High‐Energy‐Density Electrodes for Lithium‐Ion Batteries

Advanced Science, EarlyView.
A polar dispersant, aromatic‐functionalized polyacrylate (AFPA), enables the formation of a uniform CBD network by enhancing miscibility with PVDF and suppressing phase separation. This leads to α‐phase crystallization of PVDF and aligned CNT networks within the CBD, resulting in well‐connected structures that improve cohesion, electron/ion transport ...
Da‐Sol Kwon, Min Young Seo, Jinho Ahn, Yea‐Ji Jeong, Woohyeon Shin, Wonseok Ko, Min Jeong Kim, Jiny Lee, Won‐Yong Jeon, Min‐Jae Choi, Kwang In Kim, Jin Ju Eom, Sang Yeop Oh, Honghee Lee, Joona Bang, Jongsoon Kim, YongJoo Kim, Jung‐Keun Yoo   +17 more
wiley   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Nitrile and neoprene rubber nanocomposites

, 2004
The goal of this project was to determine whether the addition of organically modified montmorillonite clay improved mechanical properties and decreased permeation of a chemical warfare agent simulant in nitrile and neoprene rubber.
Croteau, Rebecca Lee, Jeffers, Sara Alyson   +1 more
core   +3 more sources

ENANTIOSELECTIVE HYDROLYSIS OF DL-PHENYLGLYCINE NITRILE

, 2014
Bacterial cultures were screened for nitrile hydratase/amidase activity towards phenylglycine nitrile. A highly active strain Rhodococcus rhodochrous 4-1 has a nonselective nitrile hydratase and extremely l-selective amidase. The amidase was isolated and
Максимов, А. Ю., Gorbunova, A. N., Maksimova, Yu. G., Максимова, Ю. Г., Maksimov, A. Yu., Горбунова, А. Н.   +5 more
core  

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

Advanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan, Shengzhou Jin, Zhao‐Dong Xu, Guigen Li, Dingyi Wang   +4 more
wiley   +1 more source