Results 41 to 50 of about 121,882 (353)

Kinetic, Spectroscopic, and X-Ray Crystallographic Evidence for the Cooperative Mechanism of the Hydration of Nitriles Catalyzed by a Tetranuclear Ruthenium-μ-oxo-μ-hydroxo Complex [PDF]

, 2008
The tetranuclear ruthenium-oxo-hydroxo-hydride complex {[(PCy3)(CO)RuH]4(μ4-O)(μ3-OH)(μ2-OH)} (1) was found to be a highly cooperative catalyst for the nitrile hydration reaction. The cooperative mechanism of the hydration of benzonitrile was established
Lindeman, Sergey V., Yi, Chae S., Zeczycki, Tonya N.   +2 more
core   +1 more source

Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium-Catalyzed Nitrile Hydration - Asymmetric Ketone Bioreduction [PDF]

, 2018
We are indebted to the MINECO of Spain (CTQ2013-40591-P and CTQ2016-75986-P) and the Gobierno del Principado de Asturias(Project GRUPIN14-006) for financial support. E.
Cadierno Menéndez, Victorio, Crochet, Pascale Veronique, García Álvarez, Joaquín, González Fernández, Rebeca, González Sabín, Javier, Liardo, Elisa, Morís, Francisco, Rebolledo Vicente, Francisca, Ríos Lombardía, Nicolás   +8 more
core   +2 more sources

Cyclic Nitriles:  Diastereoselective Alkylations [PDF]

The Journal of Organic Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Fraser F, Fleming, Subrahmanyam, Gudipati, Zhiyu, Zhang, Wang, Liu, Omar W, Steward   +4 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Swelling Properties of Nitrile-butadiene Rubber with Different Acrylonitrile Content in Isopropyl Nitrate

Chemical Engineering Transactions, 2017
Nitrile-butadiene rubber is the sealing material of isopropyl nitrate; however, leakage or vaporization phenomena frequently occur. In order to analyze the causes of leakage and volatilization and study on the various properties of nitrile-butadiene ...
Lili Wu, Yukui Ding, Jianwei Zhen, Qian Zhang, Siyang Chen   +4 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A simple, efficient and rapid screening technique for differentiating nitrile hydratase and nitrilase producing bacteria

Biotechnology Reports, 2019
Nitrile hydrolyzing enzymes catalyze the hydration of nitrile compounds to corresponding amides and acids. Bacteria, isolated from soil samples were screened for nitrile hydrolyzing enzymes by simple dye based 96 well plate and nesslerization method ...
Ruchi Sahu, Anil Kumar Meghavarnam, Savitha Janakiraman   +2 more
doaj   +1 more source

Process Development of the Copper(II)‐Catalyzed Dehydration of a Chiral Aldoxime and Rational Selection of the Co‐Substrate

ChemistryOpen, 2022
The access towards chiral nitriles remains crucial in the synthesis of several pharmaceuticals. One approach is based on metal‐catalyzed dehydration of chiral aldoximes, which are generated from chiral pool‐derived aldehydes as substrates, and the use of
Jannis Nonnhoff, Prof. Dr. Harald Gröger   +1 more
doaj   +1 more source

Nitrile ylides: allenic and propargylic structures from pyrazinylnitrenes. Experimental and theoretical characterization [PDF]

, 2014
Matrix photolysis of 2-pyrazinyl azides/tetrazolo[1,5-a]pyrazines generates nitrile ylides 15 via pyrazinylnitrenes 13 and triazacycloheptatetraenes 14.
Addicott, Chris, Baraille, Isabelle, Bednarek, Pawel, Begue, Didier, Burgard, Riko, Guille, Emilie, Wentrup, Curt   +6 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source