Results 201 to 210 of about 227,540 (298)

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet   +10 more
wiley   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

open access: yesSmall, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul   +8 more
wiley   +1 more source

A Chiral 2D Sheet for Enhancing GLUT1 Function Through the Interplay of Architecture and Recognition

open access: yesSmall, EarlyView.
We show that both supramolecular architecture and glucose chirality determine biological function. Unlike self‐assembled 0D particles, we assembled with OFN to form 2D sheets. Only the (d)‐sheets with exposed d‐glucose interacted with GLUT1, increasing its expression, promoting glucose uptake, and reducing ROS.
Yerim Kim   +7 more
wiley   +1 more source

Electronic Structure Modulation via Composition‐Preserving Phase Transformations in Metal–Organic Assemblies on the Surface

open access: yesSmall, EarlyView.
We observed composition‐preserving stepwise transformation of metal–organic self‐assembly at room temperature and systematically investigated the consequent modification in electronic structure using scanning tunneling microscopy and spectroscopy (STM/STS), combined with density functional theory (DFT) calculations.
Hyungjun Park   +5 more
wiley   +1 more source

Nitrochalcones: Pharmacological Activities and Therapeutic Potential. [PDF]

open access: yesInt J Mol Sci
Ramos-Rivera EM   +13 more
europepmc   +1 more source

Activatable smart contrast agents for photoacoustic imaging

open access: yesSmart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy