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Antibiotic Consumption and Gram-Negative Resistance Dynamics in the ICU: A Five-Year Autoregressive Integrated Moving Average (ARIMA) Analysis. [PDF]

open access: yesCureus
Rakovac Tupkovic L   +7 more
europepmc   +1 more source

Evaluating antimicrobial resistance and clinical outcomes in surgical ICU using a machine learning perspective: a retrospective observational study. [PDF]

open access: yesBMC Infect Dis
Ziaian B   +15 more
europepmc   +1 more source

Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate. [PDF]

open access: yesJ Biol Chem
Munan S   +8 more
europepmc   +1 more source
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On the mutagenicity of nitrofurans

Mutation Research, 1974
Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
D R, McCalla, D, Voutsinos
openaire   +2 more sources

6 The Nitrofurans

1967
Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
openaire   +1 more source

Oxidative Metabolites of 5-Nitrofurans

Pharmacology, 2008
We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives ...
A J, Streeter, T R, Krueger, B A, Hoener
openaire   +2 more sources

Interaction of nitrofurans with glutathione reductase

Biochimica et Biophysica Acta (BBA) - General Subjects, 1991
Nitrofurans inhibit the oxidation of NADPH by glutathione, catalyzed by yeast glutathione reductase (EC 1.6.4.2). acting as uncompetitive incomplete inhibitors for NADPH and glutathione. The quinoline-substituted nitrofurans were the most effective inhibitors.
N K, Cénas   +3 more
openaire   +2 more sources

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