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Covalent organic frameworks-based materials for antibiotics fluorescence detection. [PDF]
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On the mutagenicity of nitrofurans
Mutation Research, 1974Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
D R, McCalla, D, Voutsinos
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Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
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Oxidative Metabolites of 5-Nitrofurans
Pharmacology, 2008We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives ...
A J, Streeter, T R, Krueger, B A, Hoener
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Interaction of nitrofurans with glutathione reductase
Biochimica et Biophysica Acta (BBA) - General Subjects, 1991Nitrofurans inhibit the oxidation of NADPH by glutathione, catalyzed by yeast glutathione reductase (EC 1.6.4.2). acting as uncompetitive incomplete inhibitors for NADPH and glutathione. The quinoline-substituted nitrofurans were the most effective inhibitors.
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