Results 21 to 30 of about 17,102 (166)

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells

Frontiers in Toxicology, 2022
Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades.
Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Renxiang Chen, Heng-Hong Li, Heng-Hong Li, Albert J. Fornace, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk, Carole L. Yauk   +17 more
doaj   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Community-acquired lower urinary tract infections: Etiology, antimicrobial resistance, and treatment results in female patients

Journal of Global Infectious Diseases, 2018
Background/Purpose: Most community-acquired urinary tract infections (UTIs) are usually treated empirically. The knowledge of antibiotic resistance patterns of the microorganisms causing UTI is essential for defining the empirical treatment.
Ilknur Erdem, Ridvan Kara Ali, Enes Ardic, Senay Elbasan Omar, Reyhan Mutlu, Aynur Eren Topkaya   +5 more
doaj   +1 more source

Nitrofurantoin Failure in Elderly Men: A Retrospective Observational Study

Antibiotics, 2020
Urinary tract infections in the elderly are common. Treatment with nitrofurantoin in men may not be sufficient if concomitant tissue involvement is present, resulting in treatment failure.
Ilse Wolterink, Theo Verheij, Tamara Platteel, Ann van den Bruel, Arjen Stam, Alma van de Pol   +5 more
doaj   +1 more source

Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

Molecules, 2020
Due to the increasing use of antibiotics, measures are being taken to improve their removal from the natural environment. The support of biodegradation with natural surfactants that increase the bioavailability of impurities for microorganisms that ...
Monika Rojewska, Wojciech Smułek, Krystyna Prochaska, Ewa Kaczorek   +3 more
doaj   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Pivmecillinam compared to other antimicrobials for community-acquired urinary tract infections with Escherichia coli, ESBL-producing or not – a retrospective cohort study

Infection and Drug Resistance, 2019
Filip Jansåker,1,2 Jonas Bredtoft Boel,3 Sara Thønnings,1,2 Frederik Boëtius Hertz,3 Katrine Hartung Hansen,2 Niels Frimodt-Møller,2 Jenny Dahl Knudsen1,21Department of Clinical Microbiology, Hvidovre Hospital, University of ...
Jansåker F, Boel JB, Thønnings S, Hertz FB, Hansen KH, Frimodt-Møller N, Knudsen JD   +6 more
doaj  

Nitrofurantoin-Induced Pulmonary Toxicity: Mechanisms, Diagnosis, and Management

Toxics
Nitrofurantoin, a commonly prescribed antibiotic for urinary tract infections, has been associated with rare but potentially serious pulmonary toxicity, which can present in acute, subacute, or chronic forms.
Alan D. Kaye, Shivam S. Shah, Leon LaHaye, John A. Hennagin, Anna K. Ardoin, Alexandra Dubuisson, Shahab Ahmadzadeh, Sahar Shekoohi   +7 more
doaj   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source