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Recent advances in biocatalysis of nitrogen-containing heterocycles

Biotechnology Advances, 2022
Nitrogen-containing heterocycles (N-heterocycles) are ubiquitous in both organisms and pharmaceutical products. Biocatalysts are providing green approaches for synthesizing various N-heterocycles under mild reaction conditions. This review summarizes the recent advances in the biocatalysis of N-heterocycles through the discovery and engineering of ...
Jing, Feng   +3 more
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Nitrogen-Containing Heterocycles as Anticancer Agents: An Overview

Anti-Cancer Agents in Medicinal Chemistry, 2020
Background: Cancer is spreading all over the world, and it is becoming the leading cause of major deaths. Today’s most difficult task for every researcher is to invent a new drug that can treat cancer with minimal side effects. Many factors, including pollution, modern lifestyle and food habits, exposure to oncogenic agents or radiations, enhanced ...
Damanpreet K. Lang   +4 more
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ChemInform Abstract: Tellurium—Nitrogen‐Containing Heterocycles

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Igor D. Sadekov, Vladimir I. Minkin
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Direct C−H Carbamoylation of Nitrogen‐Containing Heterocycles

Chemistry – A European Journal, 2019
AbstractNucleophilic radical additions at innately electrophilic C(sp2) centers are perfectly suited for the direct functionalization of heterocycles. Using bench stable and commercially available alkyl oxamate and oxamic acid derivatives in combination with photoredox catalysis, a direct carbamoylation of heterocycles yielding amide functionalized ...
Matthieu Jouffroy, Jongrock Kong
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N-Heterocyclic carbene-catalysed intramolecular hydroacylation to form basic nitrogen-containing heterocycles

Organic & Biomolecular Chemistry, 2016
N-Heterocyclic carbene-catalysed intramolecular hydroacylation of N-allylimidazole-2-carboxaldehydes and N-allylbenzimidazole-2-carboxaldehydes is reported. These exo-selective hydroacylations of unactivated alkenes enable the synthesis of a variety of basic, polycyclic nitrogen heterocycles in good-to-excellent yields.
James A. Walker, Levi M. Stanley
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