Results 151 to 160 of about 2,873,864 (246)

Antimicrobial and Antioxidant Activity of Some Nitrogen-Containing Heterocycles and Their Acyclic Analogues. [PDF]

open access: yesIndian J Microbiol
Triandafilova G   +4 more
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

open access: yesAngewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean   +3 more
wiley   +1 more source

Synthesis of nitrogen-containing heterocycles

open access: yes, 2019
The sharp rise in antimicrobial resistance has been matched by a decline in the identification and clinical introduction of new classes of drugs to treat microbial infections. Thus new approaches are being sought to target pathogenic microorganisms. In that context, the use of non-biocidal small molecules, that target quorum sensing signalling networks ...
openaire   +1 more source

N-to-C Transmutations of Nitrogen-Containing Heterocycles

open access: yes
Skeletal editing is an emerging area of research that has captivated chemists, as it entails the development of methods to modify molecules with a degree of precision that existing tools do not allow for.
Mangat, Sandeep
core  

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

open access: yesAngewandte Chemie International Edition, EarlyView.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz   +3 more
wiley   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

open access: yesAngewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon   +9 more
wiley   +1 more source

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